Postnatal Changes in Plasma Ceruloplasmin and Transferrin Antioxidant Activities in Preterm Babies

Lindeman, J.; Lentjes, Eef G.W.M.; Zoeren‐Grobben, Diny van; Berger, HM

doi:10.1159/000014252

Cited by 33 publications

(23 citation statements)

References 25 publications

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“…Therefore, we excluded those infants from the study in whom severe asphyxia was present and high FiO 2 oxygen therapy was used. We assume that at normal FiO 2 levels and at normal arterial oxygen tension the free radical burden of the neonate does not become elevated during the first postnatal days, partly due to enhanced anti-oxidant capacity [21,22].…”

Section: Discussionmentioning

confidence: 99%

Expression and Activity of the Ca2+-ATPase Enzyme in Human Neonatal Erythrocytes

et al. 2001

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The plasma membrane Ca²⁺-ATPase (PMCA) is one of the main regulators of Ca²⁺ homeostasis. We studied the perinatal alteration of the abundance and the activity of PMCA molecules in human erythrocytes in pre-term and full-term neonates and children at the age of 1–4 years. The lower abundance of the 4b isoform was associated with lower enzyme activity in full-term neonates compared to children. Although the number of PMCA molecules was higher in pre-term neonates, their total PMCA activities were identical to those of full-term neonates. Our findings suggest that the abundance of PMCA molecules changes during the perinatal development. The same activity at higher enzyme molecule numbers might indicate a potential immaturity of the enzyme in the pre-term infant.

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Section: Discussionmentioning

confidence: 99%

Expression and Activity of the Ca2+-ATPase Enzyme in Human Neonatal Erythrocytes

et al. 2001

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“…Associations between iron deficiency anemia (IDA) and oxidative stress have been investigated by various investigators previously [5,19,20,32]. Increased erythrocyte susceptibility to in vitro oxidative stress [32], decreased antioxidant defense, and increased lipid peroxidation in erythrocytes [19] from adults with IDA have been determined.…”

Section: Introductionmentioning

confidence: 99%

Leukocyte DNA damage in children with iron deficiency anemia: effect of iron supplementation

et al. 2010

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Iron deficiency is frequently associated with anemia. Iron is a transition-metal ion, and it can induce free radical formation, which leads to formation of various lesions in DNA, proteins, and lipids. The aim of this study was to investigate baseline oxidative DNA damage and to clarify the role of the administration of a therapeutic dose of iron on DNA oxidation in children with iron deficiency anemia (IDA). Twenty-seven children with IDA and 20 healthy children were enrolled in the study. Leukocyte DNA damage (strand breaks and Fpg-sensitive sites) was assessed using comet assay before and after 12 weeks of daily iron administration. Before the iron administration, the frequency of DNA strand breaks in the children with IDA was found to be lower than those in the control group (P < 0.05), but there was not a significant difference for frequency of Fpg-sensitive sites. After 12 weeks of iron administration, the frequency of both DNA strand breaks and Fpg-sensitive sites were found to be increased (P < 0.01). No significant association was determined between DNA damage parameters and hemoglobin, hematocrit, serum iron, total iron binding capacity, and ferritin. In conclusion, basal level of DNA strand breaks is at a low level in children with IDA. After iron administration, DNA strand breaks and Fpg-sensitive sites, which represent oxidatively damaged DNA, increased. However, this increase was unrelated to serum level of iron and ferritin.

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“…Results showed that a change in the concentration of peroxide and antioxidants and an increase in the formation of free radicals in infants after EXT. 14 Khatami and et al in a study assessed the serum levels of Iron (Fe) and Zn after EXT and observed an increase in serum Fe and Zn levels following EXT. 15 Khoshdel et al in a study measured glucose and calcium after EXT and revealed a reduction in calcium level and no change in glucose level following EXT.…”

Section: Discussionmentioning

confidence: 99%

Study of changes in the blood levels of copper and zinc following the blood exchange transfusion in neonates with hyperbilirubinemia

et al. 2016

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Background: Blood exchange transfusion (EXT) is an essential treatment method in some icteric newborns and causes some changes in trace elements in them. The effects of blood exchange transfusion on zinc (Zn) and copper (Cu) in newborn infants is unknown. This study was conducted to determine the possible effects of EXT on Zn and Cu by comparing the levels of Zn and Cu in jaundiced neonates.Methods: In this study, 30 jaundiced term neonates undergoing EXT for the first time, because of idiopathic unconjugated hyperbilirubinemia, were selected. The Zn and Cu levels of 30 blood bank donors’ samples used for EXT were measured and 30 pairs of umbilical cord blood samples were examined for Zn and Cu before and one hour and five days after exchange transfusion. The serum bilirubin concentration was measured before and after EXT. The collected data in laboratory were analysed by statistical methods using SPSS.19. Results: In this study 43% were girls and 56.7% were boys and the average age of the infants was 4.56 days at the time of admission. Before EXT, the average of serum bilirubin was 27.74±2.03 mg/dl, and the average of serum Zn was 48.53±4.94 μg/dl that was lower than serum Zn concentration one hour after EXT (55.98±7.60 μg/dl) and five days after EXT (56.63±10.92 μg/dl). This difference was statistically significant (P=0.001). Furthermore, the average of serum Cu concentration was 59.56±10.92 μg/dl before EXT, 60.48±10.05 μg/dl after EXT and 58.64±8.06 μg/dl five days after EXT that didn't vary significantly from each other.Conclusions: The results showed that after EXT, the serum Zn concentration was higher than before EXT but the changes in serum Cu concentration was little and negligible.

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Postnatal Changes in Plasma Ceruloplasmin and Transferrin Antioxidant Activities in Preterm Babies

Cited by 33 publications

References 25 publications

Expression and Activity of the Ca<sup>2+</sup>-ATPase Enzyme in Human Neonatal Erythrocytes

Expression and Activity of the Ca<sup>2+</sup>-ATPase Enzyme in Human Neonatal Erythrocytes

Leukocyte DNA damage in children with iron deficiency anemia: effect of iron supplementation

Study of changes in the blood levels of copper and zinc following the blood exchange transfusion in neonates with hyperbilirubinemia

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