Postnatal brain development of the pulse type, weakly electric gymnotid fish Gymnotus omarorum

Iribarne, Leticia; Castelló, María E.

doi:10.1016/j.jphysparis.2014.05.001

Cited by 10 publications

(20 citation statements)

References 74 publications

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“…(c) Response of cell proliferation to predators is consistent across all three forebrain regions Adult B. occidentalis showed a spatial distribution of proliferating cells in the telencephalon consistent with the adult telencephalon of other teleost species, including two other gymnotiform electric fish: Gymnotus omarorum [36] and Apteronotus leptorhynchus [37]. Within individuals, the density was highly correlated among the three forebrain regions.…”

Section: Results (A) Forebrain Cell Proliferation Is Negatively Corrementioning

confidence: 57%

Predators inhibit brain cell proliferation in natural populations of electric fish, Brachyhypopomus occidentalis

et al. 2016

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Compared with laboratory environments, complex natural environments promote brain cell proliferation and neurogenesis. Predators are one important feature of many natural environments, but, in the laboratory, predatory stimuli tend to inhibit brain cell proliferation. Often, laboratory predatory stimuli also elevate plasma glucocorticoids, which can then reduce brain cell proliferation. However, it is unknown how natural predators affect cell proliferation or whether glucocorticoids mediate the neurogenic response to natural predators. We examined brain cell proliferation in six populations of the electric fish, Brachyhypopomus occidentalis, exposed to three forms of predator stimuli: (i) natural variation in the density of predatory catfish; (ii) tail injury, presumably from predation attempts; and (iii) the acute stress of capture. Populations with higher predation pressure had lower density of proliferating (PCNAþ) cells, and fish with injured tails had lower proliferating cell density than those with intact tails. However, plasma cortisol did not vary at the population level according to predation pressure or at the individual level according to tail injury. Capture stress significantly increased cortisol, but only marginally decreased cell proliferation. Thus, it appears that the presence of natural predators inhibits brain cell proliferation, but not via mechanisms that depend on changes in basal cortisol levels. This study is the first demonstration of predator-induced alteration of brain cell proliferation in a free-living vertebrate.

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Section: Results (A) Forebrain Cell Proliferation Is Negatively Corrementioning

confidence: 57%

Predators inhibit brain cell proliferation in natural populations of electric fish, Brachyhypopomus occidentalis

et al. 2016

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“…Some proliferation zones were extensive (such as those of the Cb and hypothalamus) whereas others were discrete (as in TeO, TS, and ELL). The resemblance between the distribution of adult G. omarorum proliferating cells and larva's distribution (Iribarne and Castelló, 2014) indicates the persistence of a specific pattern of cell proliferation throughout postnatal life in the brain of G . omarorum .…”

Section: Discussionmentioning

confidence: 98%

“…In this study we used thymidine analog labeling followed by a short survival, to identify and explore the distribution of actively cycling cells in the brain of adult G. omarorum , and test whether the proliferation zones described in late larvae (Iribarne and Castelló, 2014) persist during adulthood. To characterize the cellular composition the of adult brain proliferation zones, we evidenced main types of proliferating cells by means of the double thymidine analog labeling technique (Vega and Peterson, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…The brain of the pulse type weakly electric gymnotid Gymnotus omarorum also shows a widespread distribution of proliferation zones in late larvae (Iribarne and Castelló, 2014) and juveniles (Castelló and Iribarne, 2010) as evidenced by short chase of 5′ bromodeoxyuridine (BrdU), but the distribution of brain proliferation zones remains unexplored in adults. In late larvae and juveniles, brain regions involved in electrosensory processing show particular proliferation zones, either adjacent to the ventricular-cisternal system, for example the torus semicircularis (TS) and the tectum opticum (TeO), or distant from it [the electrosensory lateral line lobe (ELL) and the cerebellum (Cb)].…”

Section: Introductionmentioning

confidence: 99%

“…In late larvae and juveniles, brain regions involved in electrosensory processing show particular proliferation zones, either adjacent to the ventricular-cisternal system, for example the torus semicircularis (TS) and the tectum opticum (TeO), or distant from it [the electrosensory lateral line lobe (ELL) and the cerebellum (Cb)]. Mesencephalic and rombencephalic structures differ in their relative growth along postnatal development (Iribarne and Castelló, 2014), suggesting differences in the cellular composition, cell population dynamics, and/or neurogenic potential of their proliferation zones as occurs in mammals (Hermann et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

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Spatial distribution and cellular composition of adult brain proliferative zones in the teleost, Gymnotus omarorum

Olivera-Pasilio

Peterson

Castelló³

2014

Front. Neuroanat.

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Proliferation of stem/progenitor cells during development provides for the generation of mature cell types in the CNS. While adult brain proliferation is highly restricted in the mammals, it is widespread in teleosts. The extent of adult neural proliferation in the weakly electric fish, Gymnotus omarorum has not yet been described. To address this, we used double thymidine analog pulse-chase labeling of proliferating cells to identify brain proliferation zones, characterize their cellular composition, and analyze the fate of newborn cells in adult G. omarorum. Short thymidine analog chase periods revealed the ubiquitous distribution of adult brain proliferation, similar to other teleosts, particularly Apteronotus leptorhynchus. Proliferating cells were abundant at the ventricular-subventricular lining of the ventricular-cisternal system, adjacent to the telencephalic subpallium, the diencephalic preoptic region and hypothalamus, and the mesencephalic tectum opticum and torus semicircularis. Extraventricular proliferation zones, located distant from the ventricular-cisternal system surface, were found in all divisions of the rombencephalic cerebellum. We also report a new adult proliferation zone at the caudal-lateral border of the electrosensory lateral line lobe. All proliferation zones showed a heterogeneous cellular composition. The use of short (24 h) and long (30 day) chase periods revealed abundant fast cycling cells (potentially intermediate amplifiers), sparse slow cycling (potentially stem) cells, cells that appear to have entered a quiescent state, and cells that might correspond to migrating newborn neural cells. Their abundance and migration distance differed among proliferation zones: greater numbers and longer range and/or pace of migrating cells were associated with subpallial and cerebellar proliferation zones.

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Post-hatching brain morphogenesis and cell proliferation in the pulse-type mormyrid Mormyrus rume proboscirostris

Radmilovich

Barreiro²,

Iribarne

et al. 2016

Journal of Physiology-Paris

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Postnatal brain development of the pulse type, weakly electric gymnotid fish Gymnotus omarorum

Cited by 10 publications

References 74 publications

Predators inhibit brain cell proliferation in natural populations of electric fish, Brachyhypopomus occidentalis

Predators inhibit brain cell proliferation in natural populations of electric fish, Brachyhypopomus occidentalis

Spatial distribution and cellular composition of adult brain proliferative zones in the teleost, Gymnotus omarorum

Post-hatching brain morphogenesis and cell proliferation in the pulse-type mormyrid Mormyrus rume proboscirostris

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