Postmortem Whole-Body CT Angiography: Evaluation of Two Contrast Media Solutions

Ross, Steffen; Spendlove, Danny; Bolliger, Stephan A.; Christe, Andreas; Oesterhelweg, Lars; Grabherr, Silke; Thali, Michael J.; Gygax, Erich

doi:10.2214/ajr.07.3082

Cited by 182 publications

(111 citation statements)

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“…[31][32][33][34] In porcine exvivo experiments distribution defects of injected gadolinium could be simulated within the porcine myocardium, which possibly can be correlated to a disturbed antemortem perfusion as well. 31 A combination of pmMRI and minimally invasive angiography will enhance the diagnostic performance of pm imaging.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging goes postmortem: noninvasive detection and assessment of myocardial infarction by postmortem MRI

Jackowski

Warntjes²,

Berge³

et al. 2010

Eur Radiol

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Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging goes postmortem: noninvasive detection and assessment of myocardial infarction by postmortem MRI

Jackowski

Warntjes²,

Berge³

et al. 2010

Eur Radiol

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“…Improving the diagnostic yield from post-mortem MR and CT imaging is currently an area of active research (Grabherr et al, 2008;Ross et al, 2008) with the aim of "Visible Humans" to have comparable accuracy to that of conventional autopsies. Several studies have been conducted in this field to date.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional digital visible heart model and myocardial pathological characteristics of fetal single ventricle connected with aortic coarctation

Ren

Jiang²,

Xia³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. This study aimed to provide data for imaging diagnosis and clinical surgical plans by reconstructing a three-dimensional (3-D) digital visible heart model of single ventricle (SV) connection with aortic coarctation (CoA) and characterizing the myocardial and vascular wall pathological characteristics. Fifteen miscarried fetus cadavers with SV and CoA were selected. Fourteen cardiac specimens were systematically reviewed for segmental anatomy and conventional histological examinations. One fetus cadaver was used to obtain the structural dataset of the fetal body and to reconstruct a 3-D digital visible heart model. Specimen pathological dissection indicated hypertrophic myocardium SV, significant aortic wall thickening, and localized coarctation area elevation. Ten cases of SV with left ventricular morphology displayed a large muscle ridge and solitus normally aligned great arteries. Five cases of SV with right ventricular morphology had coarse, parallel trabeculations and received a common atrioventricular valve. The reconstructed 3-D heart and the main internal structures were realistic, which were beneficial for clinical and image teaching of fetal heart development. The change of characteristics of the myocardium and great vascular wall was obvious and may be the critical cause leading to progressive dysfunction in the postnatal heart.

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“…In order to perfuse a human body, paraffinum liquidum has proven to be the most appropriate [2]. The use of the more viscous paraffinum perliquidum however, may lead to significant extravasations, especially in regions with high autolytic activities such as the pancreas and gastric mucosa [40,42]. By diluting Angiofil Ò with a solvent such as decane, its viscosity can be decreased so as to enter the capillar-ies and become a contrast agent used in microangiography [43].By using Angiofil Ò together with paraffinum liquidum as solvent, as proposed according to the standardized protocol of PMCTA, the kinematic viscosity of the mixture is around 67-74 mm 2 /s (measured at 40 °C).…”

Section: Discussionmentioning

confidence: 99%

Postmortem biochemistry performed on vitreous humor after postmortem CT-angiography

et al. 2012

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a b s t r a c tPostmortem angiography is becoming increasingly essential in forensic pathology as an adjunct to con-ventional autopsy. Despite the numerous advantages of this technique, some questions have been raised regarding the influence of the contrast agent injected on the results of toxicological and biochemical anal-yses. The aim of this study was to investigate the effect of the injection of the contrast agent Angiofil Ò , mixed with paraffin oil, on the results of postmortem biochemical investigations performed on vitreous humor. Postmortem biochemical investigations were performed on vitreous samples collected from bodies that had undergone postmortem angiography (n = 50) and from a control group (n = 50). Two vit-reous samples were analyzed for each group and the results compared. Glucose, urea, creatinine, 3-b-hydroxybutyrate, sodium and chloride were tested. Different values were observed between the first and second samples in each group. However, these differences were not clinically relevant, suggesting that the injection of this contrast agent mixture does not modify the concentration of the analyzed sub-stances in the vitreous humor.

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Postmortem Whole-Body CT Angiography: Evaluation of Two Contrast Media Solutions

Cited by 182 publications

References 10 publications

Magnetic resonance imaging goes postmortem: noninvasive detection and assessment of myocardial infarction by postmortem MRI

Magnetic resonance imaging goes postmortem: noninvasive detection and assessment of myocardial infarction by postmortem MRI

Three-dimensional digital visible heart model and myocardial pathological characteristics of fetal single ventricle connected with aortic coarctation

Postmortem biochemistry performed on vitreous humor after postmortem CT-angiography

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