Postmortem Study of a Case of Werner's Syndrome

Tokunaga, Masayuki; Mori, Shigeru; Satô, Kôzô; Nakamura, Katsuhiro; Wakamatsu, Eikichi

doi:10.1111/j.1532-5415.1976.tb04129.x

Cited by 17 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Atherosclerosis and calcification can affect large extracranial and intracranial arteries, and small intracranial arteries [1,10,17,20]. Some patients have multiple small white matter infarcts and diffuse periventricular abnormalities in a pattern typical of small vessel disease [8,12].…”

Section: Discussionmentioning

confidence: 99%

Neurological complications of Werner?s syndrome

Anderson

Haas

2003

Journal of Neurology

View full text Add to dashboard Cite

Patients with Werner's syndrome have the appearance of premature ageing. Neurological complications are usually regarded as uncommon. The neurological manifestations in three patients with cardinal features of Werner's syndrome, including short stature, premature greying and baldness, thin arms and legs, cataracts and scleroderma-like skin changes, are presented. The neurological features included transient ischaemic attacks secondary to atherosclerosis in the common carotid arteries (one patient), sensory peripheral neuropathy (one patient) and peripheral neuropathy with a possible myelopathy (one patient). In one of these patients the diagnosis of Werner's syndrome was not recognised prior to neurological referral. Although neurological disease in patients with Werner's syndrome is uncommon, it may be under-recognised. Some of the neurological complications are secondary to premature cerebrovascular disease, but the pathogenesis of peripheral neuropathy and myelopathy in patients with Werner's syndrome is uncertain.

show abstract

Section: Discussionmentioning

confidence: 99%

Neurological complications of Werner?s syndrome

Anderson

Haas

2003

Journal of Neurology

View full text Add to dashboard Cite

show abstract

“…In Werner's syndrome, there is a striking preponderance of neoplasms such as hepatoma, thyroid adenocarcinoma, sarcoma of uterus, carcinoma of breast and osteogenic sarcoma [4,[7][8][9]. Among the reported nervous system tumors, the most common were meningiomas [5].…”

Section: Discussionmentioning

confidence: 99%

“…Among the reported nervous system tumors, the most common were meningiomas [5]. Neural sheath sarcomas [8] and hemangiolipoma of the spinal cord [10] have also been documented. The proband in the present family had a pathologically verified meningioma in the right parietal convexity.…”

Section: Discussionmentioning

confidence: 99%

Werner's Syndrome: A Libyan Family with Nine Affected Members

et al. 1991

View full text Add to dashboard Cite

“…However, hypergonadotrophic hypogonadism, adrenal cortical hypofunction and GH deficiency was reported previously (7). In addition, some postmortem studies revealed findings of atrophy of the endocrine glands including the genital organs (8,9). The exact mechanisms which induce these clinical manifestations are still unclear.…”

Section: Discussionmentioning

confidence: 99%

Werner Sendromlu bir olguda sıradışı organ tutulumu: tiroid atrofisi

et al. 2015

View full text Add to dashboard Cite

Werner Syndrome (WS) is a premature aging disease that begins in adolescence or early adulthood and results in the appearance of old age by 30-40 years of age. Some endocrinological abnormalities were manifested in this rare disease, such as hypogonadism, diabetes mellitus, hyperlipidemia. In this article, we present a nineteen years-old female patient who had been diagnosed as WS two years ago because of type 2 diabetes mellitus, osteopenia, hyperlipidemia, cataract, gray hair, and skin atrophy. Subclinical hypothyroidism was detected at her laboratory tests. Thyroid ultrasonography (USG) showed thyroid atrophy. Fine needle aspiration biopsy of both lobes confirmed this diagnose and excluded some infiltrative diseases such as amyloidosis. It should be kept in mind that thyroid atrophy could be seen in WS and, therefore, detailed thyroid examination including thyroid USG and close follow up should be performed in all patients with WS.Key words: atrophy; thyroid; Werner syndrome ÖZET Werner Sendromu (WS) adölesan veya erken erişkin döneminde başlayan erken yaşlanmaya neden olan bir hastalıktır. Hastalar 30-40 yaşlarında yaşlı insan görünümündedirler. Bu nadir görülen hastalıkta, hipogonadizm, diabetes mellitus ve hiperlipidemi gibi bazı endokrinolojik anormallikler de olabilmektedir. Biz bu yazıda tip 2 diabetes mellitus, osteopeni, hiperlipidemi, katarakt, gri saç ve cilt atrofisi nedeniyle iki yıldır WS tanısı ile takip edilen 19 yaşında bir bayan hasta sunduk. Hastanın yapılan labotaruvar testlerinde subklinik hipotiroidi saptandı. Tiroid ultrasonografisinde (USG) tiroidin atrofik boyutlarda olduğu gözlendi. Her iki lobdan yapılan tiroid ince iğne aspirasyonu sonucu da atrofi ile uyumlu idi ve amiloidozis gibi bazı infiltratif hastalıklar dışlandı. WS'unda tiroid atrofisinin olabileceği akılda tutulmalıdır. Bu yüzden tüm WS'lu hastalarda tiroid USG'yi de içeren detaylı tiroid muayenesi yapılmalı ve bu açıdan yakın takip edilmelidir.

show abstract

Postmortem Study of a Case of Werner's Syndrome

Cited by 17 publications

References 7 publications

Neurological complications of Werner?s syndrome

Neurological complications of Werner?s syndrome

Werner's Syndrome: A Libyan Family with Nine Affected Members

Werner Sendromlu bir olguda sıradışı organ tutulumu: tiroid atrofisi

Contact Info

Product

Resources

About