Postmortem Liver Function Tests

Naumann, Hans N.

doi:10.1093/ajcp/26.5.495

Cited by 21 publications

(5 citation statements)

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“…Total serum cholesterol, lipoproteins and apolipoproteins were stable for at least 24 h after death as already reported by several auhors [36][37][38][39][40]. Särkioja et al [41] however reported occasional unpredictable fluctuations of lipids and apolipoproteins during the 24 h-period after death and showed that triglycerides were the least stable.…”

Section: Discussionsupporting

confidence: 71%

The possible role of remnant-like particles as a risk factor for sudden cardiac death

Takeichi

Nakajima

Osawa

et al. 1997

International Journal of Legal Medicine

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Postmortem plasma lipid and lipoprotein levels were analyzed in two groups of Japanese subjects who died suddenly and unexpectedly due to cardiac (n = 93) or non-cardiac (n = 26) causes. No individuals in either group had a significant medical or cardiac history. In this study, we measured plasma total cholesterol, triglycerides, VLDL-cholesterol, LDL-cholesterol, HDL-cholesterol, and especially triglyceride-rich lipoprotein remnants. Triglyceride and apo E-rich remnant-like particles (RLP) were studied as a possible risk factor for sudden cardiac death in relation to the progression of coronary atherosclerosis. The receiver-operating characteristic curve (ROC) analysis showed that RLP-TG was the most significant risk factor for sudden cardiac death among the lipids and lipoproteins and RLP-C was the best predictor for coronary atherosclerosis. HDL-C and LDL-C levels were within normal limits in the majority of the cases and did not appear to relate to the sudden cardiac death. Apo E phenotyping was performed for the detection of the genetic background in the lipid metabolism. The frequency of the Apo E3/3 (wild type) phenotype, which closely relates with the remnant metabolism, was significantly reduced in the sudden cardiac death group. Our study on the postmortem plasma lipid analysis suggested that RLP-C and RLP-TG are the best risk predictor for coronary atherosclerosis and sudden cardiac death, respectively.

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Section: Discussionsupporting

confidence: 71%

The possible role of remnant-like particles as a risk factor for sudden cardiac death

Takeichi

Nakajima

Osawa

et al. 1997

International Journal of Legal Medicine

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“…The results of these studies, though interesting, have provided sometimes diverging conclusions on postmortem molecule stability and postmortem measurement reliability, leading to the conclusion that hepatic function assessment from postmortem laboratory investigations is of limited value or even none whatsoever. [5][6][7][8][9][10][11][12][13] The purpose of the study presented herein was twofold: a) to determine GGT, ALT, AST, ALP, total bilirubin, total proteins, and albumin in a series of cases that underwent postmortem investigations with antemortem and postmortem serum samples available for comparison, thereby investigating the postmortem stability of these compounds in blood after death, b) measure the same molecules in cerebrospinal fluid in a series of cases that underwent medicolegal investigations, thereby evaluating the distribution of these molecules in this biological sample as well as the usefulness of their determination in this specimen for diagnostic purposes in the forensic setting.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, postmortem serum levels of both proteins and ALP did not correlate closely enough with liver disease to be of value in individual cases.In a subsequent study, Naumann and Young14 found that total and direct bilirubin were demonstrable in cerebrospinal fluid, albeit in lesser amounts than in serum (cerebrospinal fluid to serum ratio of 1:35 and 1:45, respectively). Succeeding Naumann10 , Enticknap15 and Coe16 investigated ALP levels in postmortem serum and found significantly increases of up to ten times normal antemortem values 48 h after death.…”

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confidence: 99%

Usefulness of liver function tests in postmortem samples

Fumeaux

Scarpelli

Tettamanti

et al. 2018

Journal of Forensic and Legal Medicine

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Liver function tests have been investigated in the forensic setting in several biological fluids collected at autopsy. Nevertheless, the results of these investigations have provided diverging information on postmortem stability of liver function markers and postmortem reliability of liver function assessment. The first aim of this study was to determine gamma-glutamyltransferase, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, total proteins, and albumin in antemortem and postmortem serum samples in a series of cases that underwent forensic investigations and had both samples available. The second aim was to measure total bilirubin and gamma-glutamyltransferase in cerebrospinal fluid. Preliminary results indicated that femoral (and cardiac) blood postmortem serum concentrations of bilirubin, total proteins, and albumin, as well as femoral blood postmortem serum concentrations of gamma-glutamyltransferase, can be considered to reliably reflect antemortem serum concentrations, thus suggesting that postmortem values could be used as surrogates for antemortem levels. Measurable bilirubin levels were demonstrable in cerebrospinal fluid samples in both preservative-free and sodium fluoride tubes, though with levels varying widely and unpredictably, irrespective of liver disease severity.

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“…One of the first literature reviews pertaining to cholesterol, triglyceride, and apolipoprotein stability in postmortem serum samples was provided by Coe [14,15], who reported the results of the studies performed by Naumann [16], Glanville [17], Enticknap [18][19][20], Fekete and Brunsdon [21], Sturner [22], Leadbeatter and Stansbie [23], and Särkioja [12].…”

Section: Discussionmentioning

confidence: 99%

“…The results of these studies provided contradictory findings concerning cholesterol, triglyceride, and apolipoprotein (A-I and B) stability in postmortem samples and hence postmortem determination reliability. In particular, postmortem serum triglyceride levels were characterized by significant fluctuations and appeared to be of very limited value as indicators of antemortem levels [12,[14][15][16][17][18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Postmortem evaluation of cholesterol, triglyceride, and apolipoprotein levels

et al. 2017

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Cholesterol and triglyceride levels have been analyzed in the forensic setting and their values correlated with atherosclerotic lesions found at autopsy and histology. Nevertheless, the results of these investigations have provided diverging information on postmortem molecule stability and postmortem measurement reliability. The aim of this study was to determine triglycerides, total cholesterol, low-density and high-density lipoprotein cholesterol, apolipoprotein B, and apolipoprotein A-I in antemortem and postmortem serum samples in a series of cases (N = 10, including cardiac and noncardiac deaths) that underwent forensic investigations and had both samples available, measure the same molecules in postmortem serum from femoral blood and pericardial and pleural fluids (N = 39, including cardiac and noncardiac deaths), and evaluate whether different levels of these molecules could be observed in cases characterized by different degrees of coronary artery atherosclerosis (N = 39, including cardiac and noncardiac deaths). Preliminary results indicated that total cholesterol and low-density and high-density lipoprotein cholesterol levels in postmortem serum samples tended to be lower than those in antemortem specimens, whereas triglyceride levels in postmortem serum samples tended to be higher than those in antemortem samples. No relationship could be found between postmortem serum and pericardial fluid levels or between postmortem serum and pleural fluid levels of all tested biomarkers. Lastly, cases characterized by severe coronary artery atherosclerosis revealed higher postmortem serum levels of total cholesterol and apolipoprotein B. Globally considered, these data confirm that femoral blood postmortem serum levels of cholesterol and apolipoproteins may be considered suitable to estimate their antemortem values in forensic cases characterized by coronary artery atherosclerosis.

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Postmortem Liver Function Tests

Cited by 21 publications

References 0 publications

The possible role of remnant-like particles as a risk factor for sudden cardiac death

The possible role of remnant-like particles as a risk factor for sudden cardiac death

Usefulness of liver function tests in postmortem samples

Postmortem evaluation of cholesterol, triglyceride, and apolipoprotein levels

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