Postmortem evaluation of airflow limitation in obstructive lung disease.

Park, S S; Yoo, Ok Hi; Janis, Michel; Williams, M. Henry

doi:10.1152/jappl.1969.27.3.308

Cited by 16 publications

(2 citation statements)

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“…The absence of a correlation between peripheral pools and the bronchographic features of chronic bronchitis in central airways may be a function of our choice of the right upper lobe for bronchographic assessment (Ogilvie, 1975) and the relatively mild disability in the present series of subjects; the greater the involvement of proximal airways, the more likely it is that respiratory disability will be manifest (Park et al, 1969). Alternatively, it may be that there is not necessarily a close association between the central and the peripheral consequences of cigarette smoking, that is, between pools and the other generally accepted bronchographic criteria of chronic bronchitis.…”

Section: Discussionmentioning

confidence: 82%

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Peripheral pooling of bronchographic contrast material: evidence of its relationship to smoking and emphysema.

Musk¹,

Gandevia²,

Palmer³

1978

Thorax

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. Peripheral pooling of bronchographic contrast material: evidence of its relationship to smoking and emphysema. Sixty-six subjects, mainly derived from various occupational groups and one-third of whom admitted to dyspnoea on exertion, have been grouped according to the appearance of their peripheral airways at bronchography with oily propyliodone. Eleven subjects showed marked peripheral pooling of radiographic contrast material, 22 showed mild or moderate pooling, and in 33 peripheral pools were absent. Pooling was not seen in non-smoking subjects. In the group of subjects without pooling, pulmonary function in non-smokers and subjects with a history of smoking was similar. Subjects with marked pooling had a significantly lower pulmonary diffusing capacity (transfer factor) and evidence of loss of pulmonary elastic recoil when compared with subjects with absent peripheral pooling. These results indicate that bronchographic peripheral pooling is associated with the physiological changes of panacinar pulmonary emphysema and suggest that a causal relationship may exist between the organic bronchiolar lesion of pooling and the peripheral parenchymal lesion of panacinar emphysema.

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Section: Discussionmentioning

confidence: 82%

“…It appears that pools are not as closely related to disability as to bronchitis clinically and emphysema physiologically. Other studies (Park et al, 1969;Colebatch et al, 1973) in fact suggest that emphysema is not necessarily accompanied by disability, which commonly requires an additional component of bronchial disease.…”

Section: Discussionmentioning

confidence: 99%