Postmortem diagnostics of assumed food anaphylaxis in an unexpected death

Unkrig, S.; Hagemeier, Lars; Madea, Burkhard

doi:10.1016/j.forsciint.2010.01.007

Cited by 30 publications

(21 citation statements)

References 13 publications

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“…Finally, the forensic use of postmortem serum chymase levels has been tested, at present, exclusively in one study. This found a significant, positive correlation between tryptase and chymase levels, thus suggesting that measurements of mast cell-specific chymase levels could be an additional tool for the postmortem diagnosis of hypersensitivity reactions characterized by mast cell activation [59][60][61][62][63][64][65][66].…”

Section: Diagnosis Of Fatal Reactions To Contrast Agents In the Forenmentioning

confidence: 87%

Allergic reactions following contrast material administration: nomenclature, classification, and mechanisms

2013

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In forensic pathology routine, fatal cases of contrast agent exposure can be occasionally encountered. In such situations, beyond the difficulties inherent in establishing the cause of death due to nonspecific or absent autopsy and histology findings as well as limited laboratory investigations, pathologists may face other problems in formulating exhaustive, complete reports, and conclusions that are scientifically accurate. Indeed, terminology concerning adverse drug reactions and allergy nomenclature is confusing. Some terms, still utilized in forensic and radiological reports, are outdated and should be avoided. Additionally, not all forensic pathologists master contrast material classification and pathogenesis of contrast agent reactions. We present a review of the literature covering allergic reactions to contrast material exposure in order to update used terminology, explain the pathophysiology, and list currently available laboratory investigations for diagnosis in the forensic setting.

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Section: Diagnosis Of Fatal Reactions To Contrast Agents In the Forenmentioning

confidence: 87%

Allergic reactions following contrast material administration: nomenclature, classification, and mechanisms

2013

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“…The literature up to the end of 2013 is sparse on legal action in relation to food allergy, substantive analysis and comment being confined, to our knowledge, to a discussion on access to day care in the USA and a South African paper on medical negligence . The forensic science and allergy literature contains reports of food‐related deaths but no detail of any subsequent court action. The Bhamra case attracted comment mainly confined to reporting the facts .…”

Section: Discussionmentioning

confidence: 99%

Food allergy, a summary of eight cases in the UK criminal and civil courts: effective last resort for vulnerable consumers?

Gowland

Walker²

2014

J Sci Food Agric

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Food allergy has a forensic context. The authors describe eight cases in the UK courts involving fatalities, personal injury or criminal non-compliance with food law from mainly 'grey' literature sources. The potentially severe consequences for people with food allergy of contraventions of labelling law have led to enforcement action up to criminal prosecution for what might otherwise be regarded as 'trivial' non-compliance. The authors suggest there should be central collation of such cases. Non-compliances should be followed up in a more rapid and robust manner. Evidence of fraud in the catering supply chain supports recent calls for zero tolerance of food fraud. Businesses must guard against gaps in allergen management, for which there are readily available sources of training and guidance, but also against fraudulent substitution in the supply chain, about which training and guidance should be developed. New allergen labelling legislation and case law appear to place responsibility on food businesses even for the forensically problematic area of allergen cross-contamination. The courts can be an effective last resort for vulnerable consumers; however, there is evidence of knowledge and skill gaps in both the investigation and prosecution of potentially serious incidents of food allergen mismanagement and mislabelling. Thorough investigation of food allergy deaths is required with a tenacious and skilled approach, including early realisation that samples of the food and/or stomach contents from a post mortem examination should be retained and analysed. The supply chain must be rigorously examined to find out where adulteration or contamination with the fatal allergen occurred.

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“…Proteomic studies may be supportive in determining the anaphylaxis related cause of death. In a several studies evaluating postmortem blood concentrations of tryptase and ß-tryptase were detected very high in contrast medium anaphylaxis [54], less in food anaphylaxis [55], and intermediate in insect bites-related anaphylaxis [56]. On the other hand, cases as heroin-related deaths [57], or posttraumatic deaths and hearth diseases [54] were not clearly related to ß-tryptase levels.…”

Section: Diagnosis Of Disease and Cause Of Deathmentioning

confidence: 96%

“…[44] Pittner et al [45] MS-based proteomics Choi et al [46] Handke et al [47] Procopio et al [49] Prieto-Bonete et al [50] Intoxication and abuse of drugs MS-based proteomics Bittencourt et al [51] Diagnosis of disease and cause of death MS-based proteomics Broadbelt at al. [53] Palmiere et al [54] Immunohistochemistry Unkrig et al [55] Mustafa et al [56] Fineschi et al [57] Edston and van Hage-Hamsten [58] Genomics Detection of the biological specimens PCR Nakanishi et al [12] Postmortem interval PCR Pechal et al [19] Intoxication and abuse of drugs PCR Sallaee et al [62] Ikematsu et al…”

Section: Sds-page Western Blotmentioning

confidence: 99%

Omics era in forensic medicine: towards a new age

Akçan¹,

Taştekin²,

Yıldırım³

et al. 2020

Turk J Med Sci

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Introduction The topic "forensic medicine and sciences" is a subdivision of science which is described as the practice of medical/ paramedical scientific knowledge to establish facts in civil and criminal law [1]. Forensic medicine has a multidisciplinary structure in collaboration with other areas such as forensic chemistry, toxicology, biology, psychiatry, and genetics, etc. Since forensic sciences share a common scientific methodology with other science disciplines it is open to collaborate or benefit from novel technologies appeared in any scientific discipline. Therefore, omics emerges as a revolutionary step in forensic sciences and sure carries it towards a new age. The publications regarding omics in various disciplines have become a rising scientific trend worldwide, during the last decade. Furthermore, the number of forensic studies utilizing the methodology of omics has enormously increased in last years. In order to draw attention of forensic and medical professionals, and encourage new studies; the roles and benefits of omics in forensic medicine and sciences are discussed in this review. 2. Omics Omics is a novel multidisciplinary field of various scientific methodologies. Omics defines the collective technologies that measure some characteristics (roles, relationships, and actions) of certain molecules like metabolites, proteins and genes, ending in-omics, as in metabolomics, proteomics, genomics, etc. In past years, omics technologies were applied to diverse fields, because of the ability to assess little changes in a large-scale data with exhaustive metabolite evaluation [2]. With the development of technology, omics-based strategies become cheaper, faster, and very informative, and offer potent alternatives to conventional technics. Furthermore, sample selection has a key role to success in target study. Various human samples can be used for analysis such as blood [3,4], urine [5], hair [6,7], nail [8-10], faeces[11,12], aqueous humour [13] etc. The interactions of omics with each other have been shown in Figure. 2.1. Metabolomics 2.1.1. Definition of metabolomics Metabolomics comprises the studies that are focused on assessment of metabolites and related markers of an Background/aim: Forensic medicine and sciences is a multidisciplinary branch of science, which frequently benefit from novel technologies. State of the art omics technologies have begun to be performed in forensic medicine and sciences, particularly in postmortem interval, intoxication, drugs of abuse, diagnosis of diseases and cause of death. This review aims to discuss the role and use of great omics (metabolomics, proteomics, genomics and transcriptomics) in forensic sciences, in detail. Materials and methods: A detailed review of related literature was performed, and studies were subdivided as per the type of omics. Results and conclusion: Omics seems as a revolutionary step in forensic science and sure carries it towards a new age. The number of forensic studies utilizing omics steadily increases in last years. Omics strategi...

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Postmortem diagnostics of assumed food anaphylaxis in an unexpected death

Cited by 30 publications

References 13 publications

Allergic reactions following contrast material administration: nomenclature, classification, and mechanisms

Allergic reactions following contrast material administration: nomenclature, classification, and mechanisms

Food allergy, a summary of eight cases in the UK criminal and civil courts: effective last resort for vulnerable consumers?

Omics era in forensic medicine: towards a new age

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