Postmortem diagnosis of fatal hypothermia/hyperthermia by spectrochemical analysis of plasma

Lin, Hancheng; Zou, Donghua; Luo, Yang; Wang, Lei; Zhang, Zhong; Zhang, Ji; Chen, Yijiu; Wang, Zhenyuan; Huang, Ping

doi:10.1007/s12024-019-00111-8

Cited by 8 publications

(2 citation statements)

References 47 publications

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“…FT-IR was also utilized in cases of heatstroke. Previous studies indicated that the PLS-DA analysis of FT-IR data (plasma, edema fluid in formalin-fixed and paraffin-embedded lung tissues), could help to identify fatal cases of hypothermia/hyperthermia [134,135]. In anaphylactic shock cases, the pulmonary edema fluid is rich in α-helix protein structures and tyrosinerich proteins compared with other fatal causes of death [136].…”

Section: Fourier Transform Infrared Spectroscopy (Ft-ir)mentioning

confidence: 99%

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

Huang,

Zhao,

Liu

et al. 2024

IJMS

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It is well known that proteins are important bio-macromolecules in human organisms, and numerous proteins are widely used in the clinical practice, whereas their application in forensic science is currently limited. This limitation is mainly attributed to the postmortem degradation of targeted proteins, which can significantly impact final conclusions. In the last decade, numerous methods have been established to detect the protein from a forensic perspective, and some of the postmortem proteins have been applied in forensic practice. To better understand the emerging issues and challenges in postmortem proteins, we have reviewed the current application of protein technologies at postmortem in forensic practice. Meanwhile, we discuss the application of proteins in identifying the cause of death, and postmortem interval (PMI). Finally, we highlight the interpretability and limitations of postmortem protein challenges. We believe that utilizing the multi-omics method can enhance the comprehensiveness of applying proteins in forensic practice.

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Section: Fourier Transform Infrared Spectroscopy (Ft-ir)mentioning

confidence: 99%

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

Huang,

Zhao,

Liu

et al. 2024

IJMS

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“…To predict the death caused by hypothermia or hyperthermia, two binary classification models had been developed using PLS-DA. The models demonstrated 100% accuracy in predicting the death related to these two causes when used to analyze the spectra of 42 unknown samples of rat's plasma [131].…”

Section: Postmortem Diagnosis Of Weather Related Deathmentioning

confidence: 99%

Attenuated total reflection-Fourier transform infrared spectroscopy: a universal analytical technique with promising applications in forensic analyses

Alkhuder

2022

Int J Legal Med

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Contemporary criminal investigations are based on the statements made by the victim and the eyewitnesses. They also rely on the physical evidences found in the crime scene. These evidences, and more particularly biological ones, have a great judicial value in the courtroom. They are usually used to revoke the suspect's allegations and confirm or refute the statements made by the victim and the witnesses. Stains of body fluids are biological evidences highly sought by forensic investigators. In many criminal cases, the success of the investigation relies on the correct identification and classification of these stains. Therefore, the adoption of reliable and accurate forensic analytical methods seems to be of vital importance to attain this objective. Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) is a modern and universal analytical technique capable of fingerprint recognition of the analyte using minimal amount of the test sample. The current systematic review aims to through light on the fundamentals of this technique and to illustrate its wide range of applications in forensic investigations. ATR-FTIR is a nondestructive technique which has demonstrated an exceptional efficiency in detecting, identifying and discriminating between stains of various types of body fluids usually encountered in crime scenes. The ATR-FTIR spectral data generated from bloodstains can be used to deduce a wealth of information related to the donor species, age, gender, and race. These data can also be exploited to discriminate between stains of different types of bloods including menstrual and peripheral bloods. In addition, ATR-FTIR has a great utility in the postmortem investigations. More particularly, in estimating the postmortem interval and diagnosing death caused by extreme weather conditions. It is also useful in diagnosing some ambiguous death causes such as fatal anaphylactic shock and diabetic ketoacidosis.

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Recent Chemometric Opportunities in Criminalistics

Thanni¹,

Sah²,

Harrington³

2021

Encyclopedia of Analytical Chemistry

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Recently, the growing applicability of chemometrics in various areas of civil and criminal investigations has been instrumental in resolving complex cases. As criminals become more inventive and measurement methods become more prevalent with onsite analysis and more sophisticated with increases in resolution and sensitivity, forensic analysts should be equipped with tools for advancing their laboratory analysis and investigations. The traditional mode of data analysis in criminalistics will not suffice for complex crime lab investigations, hence the need for the understanding and application of the statistical and chemometric tools is indispensable. Accurate interpretation of forensic evidence is critical for achieving justice. The use of chemometrics helps the analyst from designing effective and efficient experiments to the presentation of compelling evidence to the courts. This article highlights the most recent application of chemometrics in different forensic science areas and shows how pivotal statistical tools are to answering consequential questions in criminal investigations.

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Postmortem diagnosis of fatal hypothermia/hyperthermia by spectrochemical analysis of plasma

Cited by 8 publications

References 47 publications

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

Attenuated total reflection-Fourier transform infrared spectroscopy: a universal analytical technique with promising applications in forensic analyses

Recent Chemometric Opportunities in Criminalistics

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