Postmenopausal pure rhabdomyosarcoma of the uterine corpus associated with previous pelvic irradiation

Leung, F.; Terzibachian, J.-J.; Govyadovskiy, A.; Lassabe, C.

doi:10.1007/s00404-008-0670-z

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…Between 1982 and 2015, twenty-four cases of pleomorphic rhabdomyosarcoma of the uterus have been described in the English-language literature, including the present case (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). The median age of the patients was 66.6±10.4 years with a range between 35 and 87 years.…”

Section: Discussionmentioning

confidence: 87%

“…With an estimated incidence of less than 0.5/100,000, pleomorphic rhabdomyosarcoma of the uterus is a very rare and poorly investigated disease (1,2). Mainly occurring in postmenopausal women, the leading symptoms are vaginal bleeding and abdominal pain (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Due to the high malignancy of the tumor and the inefficiency of the adjuvant therapy, the outcome remains poor in the majority of the reported cases (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Abstract Background: Pleomorphic Rhabdomyosarcomasmentioning

confidence: 99%

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Pleomorphic Rhabdomyosarcoma of the Uterus – Case Report and a Systematic Review of the Literature

Alavi

Eckes

Krätschell

et al. 2017

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Section: Discussionmentioning

confidence: 87%

Section: Abstract Background: Pleomorphic Rhabdomyosarcomasmentioning

confidence: 99%

Pleomorphic Rhabdomyosarcoma of the Uterus – Case Report and a Systematic Review of the Literature

Alavi

Eckes

Krätschell

et al. 2017

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“…A review of the English-language literature since 1969 uncovered 23 previously reported cases of pure pleomorphic rhabdomyosarcoma of the uterine corpus, as outlined in Table 5 (8,(14)(15)(16)(17)19,20,(23)(24)(25)40,41). This list only includes cases specifically reported as pleomorphic rhabdomyosarcoma or about which this diagnosis could be reasonably inferred from the caption and microscopic descriptions.…”

Section: Discussionmentioning

confidence: 96%

Pleomorphic Rhabdomyosarcoma of the Uterine Corpus: A Clinicopathologic Study of 4 Cases and a Review of the Literature

Fadare

Bonvicino

Martel

et al. 2010

International Journal of Gynecological Pathology

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We report the clinicopathologic features of 4 cases of pure pleomorphic rhabdomyosarcoma of the uterine corpus with an emphasis on their frequent expression of CD10 and CD56, review the relevant literature, and discuss differential diagnostic considerations. The patients ranged from 51 to 79 years (mean 68 y). All were FIGO stage IIIC to IV at initial surgical staging, and 3 were dead from the disease at an average of 8.6 months follow-up. In addition to the expected findings, other notable morphologic features included tumor giant cells (4/4), osteoclast-like giant cells (1/4), patchy myxoid stroma (4/4), and only infrequent cytoplasmic cross striations (1/4). The tumors in all 4 cases were positive for myogenin, myo-D1, smooth muscle actin, desmin, muscle-specific actin (HHF-35), and CD10; 3 (75%) of 4 cases were positive for calponin and CD56; all cases were negative for cytokeratin 7, synaptophysin, epithelial membrane antigen, placental-like alkaline phosphatase, chromogranin, and a pan-keratin. Twenty-three cases have been reported earlier in the English-language literature between 1969 and 2009. In combination with the current 4, the 27 patients had an age range of 35 to 87 years (mean 66.33 y). Only 1 patient was deemed inoperable; most had staging operations. Following their initial evaluations, 16 (59%) were found to have extrauterine extension of disease. At follow-up, 73% (19/27) were dead from the disease and 19.2% had no evidence of recurrence. Ten (53%) of the 19 deaths occurred within 6.5 months of initial evaluation. Stage at presentation did not have any significant impact on outcome: 73% of the 11 patients with uterus-confined disease at presentation were dead from the disease at follow-up, a rate of disease-associated death that was nearly identical to the 75% in the 16 patients with extrauterine disease at presentation. A wide variety of neoadjuvant and adjuvant therapies were administered, which did not appear to significantly impact outcomes. These data indicate that pleomorphic rhabdomyosarcoma of the uterine corpus is a highly aggressive, rapidly progressive tumor with a high case-fatality rate.

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“…In a recent report, we reviewed 23 cases reported in the English-language literature between 1969 and 2009, and reported 4 additional cases [78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93] (Table 3). The 27 patients ranged in age from 35 to 87 years (mean 66.33 y).…”

Section: Pleomorphic Rhabdomyosarcomamentioning

confidence: 98%

Heterologous and Rare Homologous Sarcomas of the Uterine Corpus

Fadare¹

2011

Advances in Anatomic Pathology

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Pure sarcomas of the uterine corpus are uncommon, constituting less than 3% of all malignancies at this site, and most of them are leiomyosarcomas and endometrial stromal sarcomas. Rare histotypes of homologous sarcomas and heterologous sarcomas are occasionally encountered, and the absence of significant accumulated experience with these histotypes at this location may potentially raise diagnostic and patient management difficulties. In this article, the clinicopathologic attributes of all earlier reported sarcomas of the uterine corpus other than leiomyosarcomas and endometrial stromal sarcomas are summarized. Included are embryonal rhabdomyosarcoma, pleomorphic rhabdomyosarcoma, angiosarcoma, alveolar soft part sarcoma, malignant perivascular epithelioid cell tumors (PEComas), osteosarcoma, chondrosarcoma, liposarcomatous tumors, malignant extrarenal rhabdoid tumors, Ewing sarcoma/primitive neuroectodermal tumor, and other rare histotypes. Embryonal rhabdomyosarcoma (20%), Ewing sarcoma/primitive neuroectodermal tumor (17%), angiosarcoma (14%), and pleomorphic rhabdomyosarcoma (13%) appeared to be more common than the others, although there was no single overwhelmingly prevalent histotype in the group. A subset, including embryonal rhabdomyosarcoma, alveolar soft part sarcoma, and PEComas, peak in the premenopausal years, but most of the others were observed in postmenopausal women. Favorable outcomes have been reported for the patients diagnosed with alveolar soft part sarcoma, and the prognosis for their counterparts with PEComa remains a matter of debate. Multimodal therapeutic approaches to contemporary patients with embryonal rhabdomyosarcomas have resulted in significantly improved outcomes. Unfortunately, most of the other sarcomas have been associated with rapid tumor progression and unfavorable patient outcomes. The differential diagnosis for these sarcomas is often extensive and varies by histotype, but their accurate diagnosis fundamentally requires the careful exclusion of biphasic malignancies.

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Postmenopausal pure rhabdomyosarcoma of the uterine corpus associated with previous pelvic irradiation

Cited by 8 publications

References 10 publications

Pleomorphic Rhabdomyosarcoma of the Uterus – Case Report and a Systematic Review of the Literature

Pleomorphic Rhabdomyosarcoma of the Uterus – Case Report and a Systematic Review of the Literature

Pleomorphic Rhabdomyosarcoma of the Uterine Corpus: A Clinicopathologic Study of 4 Cases and a Review of the Literature

Heterologous and Rare Homologous Sarcomas of the Uterine Corpus

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