Postmenopausal oestrogen replacement therapy with subcutaneous oestradiol implants

Suhonen, Satu; Sipinen, Seppo; Lähteenmäki, Pekka; Laine, Hannu; Rainio, Juha; Arko, H

doi:10.1016/0378-5122(93)90056-n

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…The observed decrease in uterine size after menopause is likely explained by lower estrogen levels [24]. Because estrogen levels drop dramatically after menopause, substantial changes in uterine volume occur only after menopause [25].…”

Section: Discussionmentioning

confidence: 97%

Ovarian Weight and Uterine Volume Index Are Useful for Age Estimation in Adult Women

Murai,

Tomioka,

Takaso

et al. 2024

Forensic Sciences

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Practically, when only parts of an unidentified human body are found, age estimation with limited materials is required. The purpose of this study was to investigate methods for estimating age using the uterus and ovaries. Among forensic autopsies performed between January 2011 and March 2022, 211 uteruses and 521 ovaries of 322 women were used for this study. Measured values for ovarian weight and uterine volume index were corrected by body surface area to consider the effect of body size. The corrected uterine volume index increased in teenage years and achieved its maximum in the 40–49 group, then gradually decreased with increasing age. The corrected ovarian weight increased until the twenties, after which it decreased with age. For women aged 20 years or more, receiver operating characteristic (ROC) curve analysis suggested that a uterine volume index of 41.2 cm3/m2 was the cutoff value for classifying the age as ≥60 years or <60 years, with an area under the ROC curve (AUC) value of 0.751. Ovarian weights of 2.27 g/m2 and 1.92 g/m2 were the cutoff values for classifying the age as ≥40 years or <40 years, or ≥50 years or <50 years, with AUC values of 0.935 and 0.930, respectively. These methods can help determine an unknown individual’s age group simply and quickly, even for incomplete cadavers.

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Section: Discussionmentioning

confidence: 97%

Ovarian Weight and Uterine Volume Index Are Useful for Age Estimation in Adult Women

Murai,

Tomioka,

Takaso

et al. 2024

Forensic Sciences

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show abstract

“…Substantial changes occurred only after the menopause, when uterine and ovarian size, endometrial thickness and number of follicle‐like cystic structures/corpora lutea decreased. The decrease in uterine size after menopause is likely to be explained by a decrease in estrogen levels16, because estrogen levels drop dramatically postmenopause15. Shrinkage of the ovaries is likely to be explained by depletion of follicles, which is a slow process starting as early as in fetal life17 and accelerating at 38 years of age or when about 25 000 follicles remain18.…”

Section: Discussionmentioning

confidence: 99%

Changes in ultrasound morphology of the uterus and ovaries during the menopausal transition and early postmenopause: a 4‐year longitudinal study

Sokalska

Valentin

2008

Ultrasound in Obstet & Gyne

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Objectives To describe changes in uterine and ovarian size and morphology as determined by ultrasonography from 2 years before to 2 years after menopause. ('cycle day' 8-196) and images compatible with the luteal phase in 7% (10/150) ('cycle day' 11-56). Intraovarian cystic structures (3-25 mm) were seen in 14 women after the menopause. Methods ConclusionWe have described sonographic changes in the uterus and ovaries occurring during the transition from premenopause to postmenopause.

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“…In addition, expression of numerous hepatic substances whose synthesis is sensitive to estrogens will be increased. Subcutaneous alternatives with administration via pellets exist for humans as well [168], but are not very commonly used. The inclusion of a peroral Nutella ® group in Paper I was an attempt to address this issue and offer a possibility to bridge the gap between preclinical and clinical studies.…”

Section: The Clinical Situationmentioning

confidence: 99%

Challenges in experimental stroke research : The 17β-estradiol example

Ingberg¹

2016

Linköping University Medical Dissertations

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Postmenopausal oestrogen replacement therapy with subcutaneous oestradiol implants

Cited by 7 publications

References 23 publications

Ovarian Weight and Uterine Volume Index Are Useful for Age Estimation in Adult Women

Ovarian Weight and Uterine Volume Index Are Useful for Age Estimation in Adult Women

Changes in ultrasound morphology of the uterus and ovaries during the menopausal transition and early postmenopause: a 4‐year longitudinal study

Challenges in experimental stroke research : The 17β-estradiol example

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