Postmenopausal hormone replacement therapy and risk of acute pancreatitis: a prospective cohort study

Abstract

Interpretation: Use of postmenopausal hormone replacement therapy was associated with increased risk of acute pancreatitis. Physicians should consider this potential increase in risk when prescribing such therapy.

Risk factors for pancreatitis in older women: the Iowa Women's Health Study

“…Finally, we observed an association of HRT use with both AP and CP, which is in agreement with other studies 39,40 . A prospective study of over 31,000 Swedish women reported that women who had ever used HRT had a 57% greater risk of developing AP than never users; the risk did not differ significantly between present and former use 39 .…”

“…A prospective study of over 31,000 Swedish women reported that women who had ever used HRT had a 57% greater risk of developing AP than never users; the risk did not differ significantly between present and former use 39 . Given that a substantial proportion of women in the U.S. report HRT use (38.5% in the IWHS), it is important to further evaluate this association.…”

Polypharmacy and risk of acute pancreatitis

“…In contrast to the sparse data on polypharmacy per se, the use of specific drugs has received more systematic study in relation to risk of acute pancreatitis. As an example, our group has found positive associations with tetracycline, antidopaminergic drugs, selective serotonin reuptake inhibitors, oral glucocorticoids, and postmenopausal hormone replacement therapy . Other research has at the same time indicated that comorbid conditions can cause acute pancreatitis, such as cardiovascular disease and diabetes .…”

“…As an example, our group has found positive associations with tetracycline, 6 antidopaminergic drugs, 9 selective serotonin reuptake inhibitors, 10 oral glucocorticoids, 11 and postmenopausal hormone replacement therapy. 12 Other research has at the same time indicated that comorbid conditions can cause acute pancreatitis, such as cardiovascular disease 13 and diabetes. 14 However, as shown with the case of diabetes, it can be difficult to disentangle the effect of the comorbid condition from the effect of the drug treatment for that condition.…”

Estrogen-induced acute pancreatitis: A case report and literature review

“…Acute pancreatitis has been described in subjects using oral contraceptives, IVF-patients without using estrogen, and there is a report of increase risk of acute pancreatitis in postmenopausal women using hormone therapy [ 2 3 4 ]. Here we report a case of estrogen-induced acute pancreatitis in which estrogen was administered for the cryo-thaw ET.…”