Postmastectomy radiation

Fowble, Barbara

doi:10.1002/(sici)1097-0142(19970315)79:6<1061::aid-cncr1>3.0.co;2-j

Cited by 18 publications

(8 citation statements)

References 42 publications

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“…Depending on previous treatment, estrogen receptor (ER)/progesterone receptor (PR) status, and other prognostic factors, tamoxifen or other hormone therapy or cytotoxic chemotherapy may be considered. Although many of these patients achieve long‐term disease‐free control, patients who develop an isolated local‐regional recurrence tend to have a poor prognosis, with 5‐year postrecurrence survival rates ranging from 40% to 70% and with disease‐free survival ranging from 13% to 50% 1, 3–15. Compared with the numerous, randomized, clinical trials evaluating systemic treatment in the primary management of breast carcinoma, there have been limited trials evaluating systemic therapy options at the time of local‐regional recurrence 1, 4, 11.…”

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confidence: 99%

Molecular markers for prognosis after isolated postmastectomy chest wall recurrence

Haffty

Hauser

Choi

et al. 2004

Cancer

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BACKGROUND Local chest wall recurrence after mastectomy occurs in 10–20% of patients with operable breast carcinoma. The objective of the current study was to assess the prognostic value of molecular markers at the time of local recurrence and to compare these markers with clinical variables. METHODS Between 1975 and 1999, the authors treated 113 patients at their institution for postmastectomy chest wall recurrences with full‐course external beam radiotherapy. Patients who presented primarily with lymph node recurrences or with simultaneous distant metastasis were excluded. Follow‐up from the time of chest wall recurrence was 10.13 years. All clinical and pathologic data from the original diagnosis and from the time of chest wall recurrence were entered into a computerized database. Paraffin‐embedded tumor specimens from the chest wall recurrences were available for 43 patients and were constructed into tissue microarrays for immunohistochemical staining of estrogen receptor, progesterone receptor (PR), p53, HER‐2/neu, and cyclin D. RESULTS Overall survival after chest wall recurrence for the entire cohort was 46% at 5 years and 28% at 10 years. The distant metastasis–free survival rate was 49% at 5 years and 40% at 10 years. Local‐regional control of disease was achieved in 79% of patients at 10 years. In multivariate analysis, significant factors for distant metastasis after local recurrence were time to recurrence (< 2 years from the original diagnosis to chest wall recurrence) and PR status (distant metastasis–free survival rate: 84% [PR‐positive] vs. 38% [PR‐negative]; P = 0.007). The only significant factor for local‐regional disease progression was HER‐2/neu status. Patients with positive HER‐2/neu status had a local‐regional progression‐free rate of 59%, compared with 92% for patients with negative HER‐2/neu status. CONCLUSIONS The prognosis for patients after local‐regional recurrence of breast carcinoma is relatively poor. Longer time to local recurrence and positive PR status were associated with favorable distant metastasis–free rates and long‐term survival. Positive HER‐2/neu status was associated with poorer local‐regional control of disease. Implications for systemic therapy and further studies are discussed. Cancer 2004;100:252–63. © 2003 American Cancer Society.

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Molecular markers for prognosis after isolated postmastectomy chest wall recurrence

Haffty

Hauser

Choi

et al. 2004

Cancer

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“…[3][4][5][6] Three recently reported randomized trials have suggested a survival benefit with postmastectomy radiation therapy (PMRT) in high-risk breast cancer patients. [3][4][5][6] Three recently reported randomized trials have suggested a survival benefit with postmastectomy radiation therapy (PMRT) in high-risk breast cancer patients.…”

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Decision-Analytic Model and Cost-Effectiveness Evaluation of Postmastectomy Radiation Therapy in High-Risk Premenopausal Breast Cancer Patients

Lee

Glick

Hayman

et al. 2002

JCO

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“…Results of numerous studies underline the high risk of recurrence of breast carcinoma in men and young women, especially with breast-conserving surgeries. According to Fowble ( 1997 ), local recurrence appeared in 40 % of patients younger than 35 years and only in 13 % of patients older than 50 years during 4.5 years of follow-up. Local recurrence results in the dissemination of tumoral process in 20-40 % of cases.…”

Section: Breast Traumamentioning

confidence: 99%

Imaging of Male Breast Cancer

Sencha¹

2015

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Postmastectomy radiation

Abstract: issue of adjuvant chemotherapy with or without radiation in these delphia, PA 19104. high risk patients. 20,24 -29 All of these trials have demonstrated a decreased incidence of locoregional recurrence with the addition of

Cited by 18 publications

References 42 publications

Molecular markers for prognosis after isolated postmastectomy chest wall recurrence

Molecular markers for prognosis after isolated postmastectomy chest wall recurrence

Decision-Analytic Model and Cost-Effectiveness Evaluation of Postmastectomy Radiation Therapy in High-Risk Premenopausal Breast Cancer Patients

Imaging of Male Breast Cancer

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