Postischemic functional recovery and BMIPP uptake after primary percutaneous transluminal coronary angioplasty in acute myocardial infarction

Early Positive Biomarker in Relation to Myocardial Necrosis and Impaired Fatty Acid Metabolism in Patients Presenting With Acute Chest Pain at an Emergency Room

“…In this study, myocardial metabolic injury was also evaluated by fatty acid imaging with BMIPP because myocardial fatty acid metabolism is more susceptible to ischemia and could be a better marker of myocardial injury than myocardial perfusion abnormality. [21][22][23][24] Cardiac fatty acid metabolism is impaired even in the myocardium that survives after an acute ischemic event, and impaired BMIPP uptake is closely related to intracellular high-energy phosphate depletion due to ischemia 22 and to regional wall motion abnormality. 23,24 The present study showed that the first single-point troponin data on arrival can reflect injured myocardial mass, although the accuracy is limited and peak values of biomarkers more closely correlated with scintigraphically assessed injured mass than did the first singlepoint data.…”

“…[21][22][23][24] Cardiac fatty acid metabolism is impaired even in the myocardium that survives after an acute ischemic event, and impaired BMIPP uptake is closely related to intracellular high-energy phosphate depletion due to ischemia 22 and to regional wall motion abnormality. 23,24 The present study showed that the first single-point troponin data on arrival can reflect injured myocardial mass, although the accuracy is limited and peak values of biomarkers more closely correlated with scintigraphically assessed injured mass than did the first singlepoint data. This is because the accuracy depends not only on timing of patient arrival at an emergency room after onset of chest pain, but also on the process by which biomarkers are released into the blood following acute ischemic injury.…”

Usefulness of Simultaneous Evaluations of Contractile Reserve, Perfusion, and Metabolism During Dobutamine Stress for Predicting Wall Motion Reversibility (Myocardial Stunning) After Successful PTCA

“…Arnese, et al 20) recently reported that in patients with chronic left ventricular dysfunction, low dose dobutamine stress echocardiography and dobutamine stress-reinjection with thallium-201 scintigraphy have a comparable sensitivity for predicting regional myocardial recovery after surgical revascularization, whereas the specificity of low dose dobutamine stress echocardiography was significantly higher than thallium scintigraphy. On the other hand, the functional outcome of myocardial regions after reperfusion 7,18) and the degree of functional improvement 21) were predicted by the mismatch of perfusion and free fatty acid metabolism in the previous studies.…”

Relationship Between the Mismatch of 123I-BMIPP and 201Tl Myocardial Single-Photon Emission Computed Tomography and Autonomic Nervous System Activity in Patients With Acute Myocardial Infarction

“…It is reported that the improvement of perfusion metabolism mismatch in acute myocardial infarction may reflect subsequent recovery from the postischemic wall motion abnormality in metabolically impaired but viable myocardium after coronary reperfusion. 11,15) Autonomic function was measured in the present study using power spectra obtained by frequency analysis using FFT. HF decreases in ischemic heart dis-ease, 16) congestive heart failure, 17) physical inactivity, 18) respiratory distress, 19) left ventricular hypertrophy, 20) and aging, 21) and it has been reported that HF increases due to β-blocker and angiotensin-converting enzyme inhibitor administration, and the administration of some calcium antagonists.…”