Postirradiation morphea and subcutaneous polyarteritis nodosa: Case report and literature review

Reddy, Soumya; Pui, John; Gold, Leslie I.; Mitnick, Hal J.

doi:10.1016/j.semarthrit.2004.11.004

Cited by 36 publications

(34 citation statements)

References 28 publications

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“…18 One patient developed PIM with subcutaneous polyarteritis nodosa. 17 It is believed that systemic sclerosis is a relative risk factor for developing an exaggerated post-irradiation fibrosis. Age and radiotherapy parameters such as total radiation dose, dose per fraction and severity of acute reaction do not seem to be significant risk factors for developing post-irradiation morphea (PIM).…”

Section: Resultsmentioning

confidence: 99%

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Post-Irradiation Morphea: Case report and review of the literature

Alhathlool

Hein²,

Andrés³

et al. 2012

J Dermatol Case Rep

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Background/Purpose: Post-irradiation morphea (PIM) is an entity documented in the literature although still not mentioned in most of the dermatological textbooks with a frequency approximately 2 out of every 1000 patients who received radiotherapy. Most of the cases are misdiagnosed as recurrent or metastatic carcinoma. Main observations:We report on a 64-year-old woman who was treated with radiotherapy for breast cancer. Two years and eight months after the first dose of radiotherapy, she developed localized morphea in the irradiated area. Conclusion:We report on a new case with a literature review and discuss pathogenesis, treatment modalities and post irradiation subcutaneos reactions mimicking PIM. Around 54 cases of post-irradiation morphea (PIM) were identified in the literature. (J Dermatol Case Rep. 2012; 6(3): 73-77)

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Section: Resultsmentioning

confidence: 99%

“…The normal balance of the fibroblast is disrupted by radiation treatment and this may be a mechanism contributing to the increased collagen production and fibrosis seen in PIM. 17 The natural history of PIM is poorly described. Skin changes may be improved within few months till few years but the pigmentation usually persists.…”

Section: Discussionmentioning

confidence: 99%

Post-Irradiation Morphea: Case report and review of the literature

Alhathlool

Hein²,

Andrés³

et al. 2012

J Dermatol Case Rep

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“…A significant number of cases of morphoea have been reported after irradiation for breast cancer, and is estimated to be in the order of one in 500 [27 ]. Chronic venous insufficiency with resultant local hypoxaemia may also be a potential trigger [28].…”

Section: Aetiologymentioning

confidence: 99%

Localized scleroderma

Laxer

Zulian

2006

Current Opinion in Rheumatology

337

300

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“…A summary of the 31 published cases of postirradiation morphea in patients treated for breast cancer is provided in Table 5 [2][3][4][5][6][7][8][11][12][13][14][15][16][17]. The estimated incidence of this complication of radiotherapy is 1:500 patients [14], in contrast to that of morphea (of any etiology), which is 2.7 per 100 000 of the general population per year [7].…”

Section: Discussionmentioning

confidence: 99%

“…Occurring as an idiosyncratic reaction, independent of the severity of acute radiodermatitis, its temporal relationship to treatment has been inconsistent and its main significance lies in its clinical mimicry of locally recurrent carcinoma. With the benefit of emerging data, it has become clear that this complication of radiotherapy can also develop as a sequel to treatment of cancers at sites other than the breast [2][3][4] and that it can, on occasion, extend beyond the portal of irradiation [2,[4][5][6][7][8]. Moreover, the related entity, lichen sclerosus et atrophicus (LS&A), observed not infrequently in association with morphea and considered to be part of the same spectrum of disease, has been documented to occur in this clinical setting [9,10].…”

Section: Introductionmentioning

confidence: 99%