Postinfective bowel dysfunction following<i>Campylobacter enteritis</i>is characterised by reduced microbiota diversity and impaired microbiota recovery

Jalanka, Jonna; Gunn, David; Singh, Gulzar; Krishnasamy, Shanthi; Lingaya, Melanie; Crispie, Fiona; Finnegan, Laura; Cotter, Paul D.; James, Louise A; Nowak, Adam; Major, Giles; Spiller, Robin C.

doi:10.1136/gutjnl-2021-326828

Cited by 13 publications

(7 citation statements)

References 48 publications

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“…After removing duplicates and records published before 2018, 765 records were screened for titles and abstracts. Of these, 23 reports were assessed for their eligibility, and 11 complied with the inclusion criteria [23][24][25][26][27][28][29][30][31][32][33].…”

Section: Search Resultsmentioning

confidence: 99%

Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analyses

Schorling,

Knorr,

Lick

et al. 2023

Public Health Challenges

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IntroductionReactive arthritis (REA) and Guillain–Barré syndrome (GBS) are postinfectious complications of Campylobacter enteritis (CE); associations with inflammatory bowel diseases and irritable bowel syndrome (IBS) are also discussed. The objective of this study was to summarize existing evidence on the probability of sequelae following confirmed CE.MethodsAll studies included in previous reviews and meta‐analyses on this topic were retrieved and assessed for eligibility; a systematic literature search was conducted to collect more recent reports. For each sequela, random effects meta‐analyses were performed; the risk of bias and the quality of evidence were evaluated.ResultsIn total, 50 reports of observational studies were included; between 110,765 and 175,839 CE cases were considered for each sequela. The pooled proportion of CE cases that developed a sequela was 1.72% (95% CI 0.81–3.61; prediction interval [PI]: 0.03–47.65) for REA, 0.07% (0.03–0.16; PI: 0.003–1.59) for GBS, 0.22% (0.06–0.73; PI: 0.002–20.69) for Crohn's disease (CD), 0.35% (0.11–1.15; PI: 0.003–28.16) for ulcerative colitis (UC), and 4.48% (1.92–10.08; PI: 0.09–70.62) for IBS. The high between‐study heterogeneity could partially be explained by study size and design, the method of assessing sequelae, and the period between CE and sequelae onset. The quality of evidence was rated as moderate for GBS and UC, and low for REA, CD, and IBS.ConclusionUpdated estimates of the probability to develop sequelae after CE are provided, for CD and UC for the first time. However, uncertainty regarding the true probabilities remains, which is reflected in the broad PIs.

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Section: Search Resultsmentioning

confidence: 99%

Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analyses

Schorling,

Knorr,

Lick

et al. 2023

Public Health Challenges

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“…When it comes to perturbations such as infections and changes in the diet, a healthy gut microbiome is resilient to disturbance and able to recover the original composition whereas a non-resilient microbiome may shift to a maladaptive status of dysbiosis. 22 The previous study showed that the Coxsackievirus -infected mouse gut virome changed vastly and had significant alterations in the alpha diversity and beta diversity during the progression of virus infection. 23 Lu et al identified a significantly lower alpha diversity of the gut virome in diarrheal dairy calves.…”

Section: Discussionmentioning

confidence: 99%

Viral metagenomics of the gut virome of diarrheal children with Rotavirus A infection

Bao

Wang

et al. 2023

Gut Microbes

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Diarrhea is a leading cause of morbidity and mortality in children worldwide and represents a major dysbiosis event. Rotavirus has been recognized as a global leading pathogen of diarrhea. This study is aimed at investigating differences in the gut virome between diarrheal children and healthy controls. In 2018, 76 diarrheal fecal samples and 27 healthy fecal samples in Shanghai and 40 diarrheal fecal samples and 19 healthy fecal samples in Taizhou were collected to investigate the composition of the gut virome. Viral metagenomic analyses revealed that the alpha diversity of the diarrheal virome was not significantly different from that of the healthy virome, and the beta diversity had a significant difference between diarrheal and healthy children. The diarrheal virome was mainly dominated by the families Adenoviridae , Astroviridae , Caliciviridae , and Picornaviridae . Meanwhile, the healthy virome also contains phages, including Microviridae and Caudovirales . The high prevalence of diverse enteric viruses in all samples and the little abundance of Microviridae and Caudovirales in diarrheal groups were identified. The study introduced a general overview of the gut virome in diarrheal children, revealed the compositional differences in the gut viral community compared to healthy controls, and provided a reference for efficient treatments and prevention of virus-infectious diarrhea in children.

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“…3e). Campylobacter is a landmark genus causing enteritis [97], indicating increased disease risks. Conversely, the Odoribacter has been shown to able to effectively limit intestinal inflammation [98], this indicates that the microbiota in the jejunal digestion site of goats has the potential role of resisting intestinal inflammation.…”

Section: Microbial Community Dynamics Along Goat Git Were Driven By D...mentioning

confidence: 99%

The multi-kingdom microbiome of the goat gastrointestinal tract

Cao,

Feng,

et al. 2023

Microbiome

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Background Goat is an important livestock worldwide, which plays an indispensable role in human life by providing meat, milk, fiber, and pelts. Despite recent significant advances in microbiome studies, a comprehensive survey on the goat microbiomes covering gastrointestinal tract (GIT) sites, developmental stages, feeding styles, and geographical factors is still unavailable. Here, we surveyed its multi-kingdom microbial communities using 497 samples from ten sites along the goat GIT. Results We reconstructed a goat multi-kingdom microbiome catalog (GMMC) including 4004 bacterial, 71 archaeal, and 7204 viral genomes and annotated over 4,817,256 non-redundant protein-coding genes. We revealed patterns of feeding-driven microbial community dynamics along the goat GIT sites which were likely associated with gastrointestinal food digestion and absorption capabilities and disease risks, and identified an abundance of large intestine-enriched genera involved in plant fiber digestion. We quantified the effects of various factors affecting the distribution and abundance of methane-producing microbes including the GIT site, age, feeding style, and geography, and identified 68 virulent viruses targeting the methane producers via a comprehensive virus-bacterium/archaea interaction network. Conclusions Together, our GMMC catalog provides functional insights of the goat GIT microbiota through microbiome-host interactions and paves the way to microbial interventions for better goat and eco-environmental qualities.

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Postinfective bowel dysfunction followingCampylobacter enteritisis characterised by reduced microbiota diversity and impaired microbiota recovery

Cited by 13 publications

References 48 publications

Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analyses

Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analyses

Viral metagenomics of the gut virome of diarrheal children with Rotavirus A infection

The multi-kingdom microbiome of the goat gastrointestinal tract

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