Postinfection Post-vaccination Autoimmune Neural Long COVID-19

Abstract

Normal human subject can have baseline auto-antibodies and auto-reactive immune cells constituting the normal physiological autoimmune state. On, post- sars-cov-2 infection and post-vaccination periods either the virus built in spike protein in case of post-infection . Or the peptide expressed from the spike protein sequence within the human COVID -19 mRNA vaccines have an auto-reacting epitopes within the human vaccinee cells. Both of the virus spike protein and vaccinee cells are bearing either pan-sharing molecular mimicking or mono-specific molecular mimicking epitopes that initiate on continual exposure to the immune system cells mediating an autoimmune responses. Such responses may cause an immune conversion of the antibody and /or auto-reactive immune cells levels from the baseline limits to the clinically indicative levels of auto-antibody and/or auto-reacting cells. The immune conversion state may pose to an autoimmune tissue injuries as single or multiple organs defects expressing the patho-biologic features of autoimmune long COVID-19.This mechanistic view to the long Covid-19 is parallel with inclusion of long COVID-19 on the list of autoimmune registry 2021.Some workers holds the believe that autoimmune long COVID-19 is an auto-antibody mediated condition .Other workers are of the opinion that both auto-antibody and auto-reacting immune cells may be involved in, Though there is still existing some debate .A literature show case analysis of neural autoimmune long COVID-19 was tempted .A laboratory animal model for Post-infection-Post-vaccination autoimmune long COVID-19 was suggested .Both of these disease entities are being over-lapping.

Anergy in COVID-19 Infected and COVID-19 vaccinee

“…Like the state of normal human being in whom there are percentages of auto-reactive cells and autoantibodies that represent the baseline levels of normal physiological autoimmune reactions [29][30][31][32][33]. There are normal levels of anergic immune cells like anergic B, anergic T and anergic myeloid cells [9].…”

“…A 1.5 folds decrease in ASSA titers in the previously exposed. Thus, vaccination in non-exposed express prime-boost effects and in previously exposed express boost anergy effects [33,34]. Continual exposure to COVID vaccine induced anergy.…”