Posthypoxic Encephalopathy in Patients After Cardiosurgical Interventions: Prevention Strategies and Neuroprotection (Literature Review)

Alekseeva, T.M.; Portik, O. A.

doi:10.18565/pharmateca.2018.10.30-35

Cited by 1 publication

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“…In addition, Semax has been shown to significantly increase the survival of cerebellar granule neurons during glutamate neurotoxicity, which may be mediated by its effect on calcium homeostasis and the functional state of mitochondria [38]. Clinical studies of the effect of Semax on the restoration of amnestic brain func-tion in patients with severe postresuscitational pathology (intellectual and mental disorders) showed that the majority of patients treated with Semax exhibited significant improvement [39]. Nevertheless, in the present study, Semax failed to show any neuroprotective effects, possibly because it might not affect the DA neurons, or because dose used was too small.…”

Section: Semaxmentioning

confidence: 99%

Synthetic Peptides Affect the Expression of <i>Gdnf</i> and Gdnf Receptors in Rats with 6-OHDA-Induced PD-Like Parkinsonism

Filatova¹,

Шадрина²,

Kolomin³

et al. 2016

WJNS

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Parkinson's disease (PD) is the second most common severe neurodegenerative disorder. It is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. Unfortunately, PD remains incurable. Therapy based on regulatory peptides, particularly neuroprotective peptides, which can sustain or activate neuron plasticity to enable their survival and function in difficult environments and after violated homeostasis, is a promising approach to cure PD. Some studies show that the synthetic analogs of natural peptides may be used as an etiological or at least a complementary therapy in PD. Therefore, in the present pilot study, we investigated the effects of the synthetic peptides Semax and dopamine neuron stimulating peptide (DNSP-5), and a new synthetic Semax-DNSP-5 hybrid peptide (SD) on the functioning of brain neurons. An analysis of the levels of dopamine (DA), noradrenaline (NA), 5-hydroxytriptamine (5-HT), an expression analysis of Gdnf and Gdnf receptor genes Gfra1, Gfra2, Gfra3, Gfra4, and Gfral in various regions of the brain of rats with 6-OHDA-induced PD-like parkinsonism, and a study of the motor activity of the rats in an "open field" test showed that DNSP-5 and SD elevated the level of DA in the nonlesioned striatum. DNSP-5 also increased the expression of Gfra1 and Gfra2 in the nonlesioned striatum and lesioned substantia nigra (SN) which suggested that DNSP-5 had compensatory and neuroprotective properties. SD demonstrated similar, albeit less pronounced effects to DNSP-5 on DA metabolism and gene expression. Of the peptides studied, only SD tended to increase the horizontal and vertical activity of rats. In conclusion, these findings suggest that DNSP-5 and SD have potential neuroprotective properties and may stimulate the surviving DA neurons.

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Section: Semaxmentioning

confidence: 99%

Synthetic Peptides Affect the Expression of <i>Gdnf</i> and Gdnf Receptors in Rats with 6-OHDA-Induced PD-Like Parkinsonism

Filatova¹,

Шадрина²,

Kolomin³

et al. 2016

WJNS

View full text Add to dashboard Cite

show abstract

Posthypoxic Encephalopathy in Patients After Cardiosurgical Interventions: Prevention Strategies and Neuroprotection (Literature Review)

Cited by 1 publication

References 0 publications

Synthetic Peptides Affect the Expression of <i>Gdnf</i> and Gdnf Receptors in Rats with 6-OHDA-Induced PD-Like Parkinsonism

Synthetic Peptides Affect the Expression of <i>Gdnf</i> and Gdnf Receptors in Rats with 6-OHDA-Induced PD-Like Parkinsonism

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Posthypoxic Encephalopathy in Patients After Cardiosurgical Interventions: Prevention Strategies and Neuroprotection (Literature Review)

Cited by 1 publication

References 0 publications

Synthetic Peptides Affect the Expression of &lt;i&gt;Gdnf&lt;/i&gt; and Gdnf Receptors in Rats with 6-OHDA-Induced PD-Like Parkinsonism

Synthetic Peptides Affect the Expression of &lt;i&gt;Gdnf&lt;/i&gt; and Gdnf Receptors in Rats with 6-OHDA-Induced PD-Like Parkinsonism

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Synthetic Peptides Affect the Expression of <i>Gdnf</i> and Gdnf Receptors in Rats with 6-OHDA-Induced PD-Like Parkinsonism

Synthetic Peptides Affect the Expression of <i>Gdnf</i> and Gdnf Receptors in Rats with 6-OHDA-Induced PD-Like Parkinsonism