Postherpetic Wolf's isotopic response: possible contribution of resident memory T cells to the pathogenesis of lichenoid reaction

Ise, Misaki; Tanese, Keiji; Adachi, Takeya; Du, Wenjie; Amagai, Masayuki; Ohyama, Manabu

doi:10.1111/bjd.13968

Cited by 8 publications

(9 citation statements)

References 9 publications

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“…In patient 20, CD117 + MCs and CD138 + plasma cells revealed that inflammatory infiltration might differ, as clinical manifestations varied. Moreover, eosinophils (43,44) and neutrophils (14) were found in patients 3, 7, 19, and 24 in our study, as well as in previous studies.…”

Section: Inflammatory Infiltrations In Wolf's Isotopic Responsesupporting

confidence: 92%

“…Patients 12 and 21 showed lichenoid infiltration, and CD4 + and CD8 + T cells in the epidermis and dermis were both present at near normal ratios; this finding differs from that of previous reports. Ise et al (14) found that most lymphocytes in the epidermis were CD8 + , while approximately equal numbers of CD4 + and CD8 + lymphocytes were detected in the dermis in a lichenoid reaction. We compared the clinical features in Ise's report with those in patients 12 and 21 in the present study.…”

Section: Inflammatory Infiltrations In Wolf's Isotopic Responsementioning

confidence: 99%

“…Other investigations have indicated that cutaneous reactions appearing at sites of HPZ scars are not due to the presence of persistent VZV DNA within lesions (5,12,13). One study suggested that the previously unrecognised existence of resident memory CD8 + T cells may contribute to the pathogenesis of lichenoid reactions in postherpetic WIR lesions (14). The density of epidermal nerve endings in previously HPZ-affected skin is reduced, compared with normal skin (15).…”

Section: Mechanism and Pathogenesis Of Wolf's Isotopic Responsementioning

confidence: 99%

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Wolf’s Isotopic Response after Herpes Zoster Infection: A Study of 24 New Cases and Literature Review

Wang

Zhang²,

Zhang³

et al. 2019

Acta Derm Venerol

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SIGNIFICANCEWolf's isotopic response (WIR) is widely accepted as a clinical concept. Twenty-four new patients presented with WIR after herpes zoster were enrolled in this study including first described disease. Based on the mini literature review and histopathological study in this study, we tend to a hypothesis that WIR caused by neuro-immune impairment and propose a classification method based on pathological findings, the epidermal and follicular changes, dermal tissue changes, inflammatory infiltrations and malignant invasions in WIR. Through the study in this paper, clinicians are reminded to be aware of this phenomenon, especially the possibility of associated tumorous diseases.Wolf's isotopic response refers to the occurrence of a new skin disease at the exact site of an unrelated skin disease that had previously healed. Various cutaneous lesions have been described after herpes zoster. This study included 24 patients with Wolf's isotopic response after herpes zoster infection, which presented as manifestations ranging from inflammatory disease to carcinoma. Histopathological examinations in 12 patients and immunohistochemical analyses in 10 patients allowed exploration of secondary microscopic changes in the lesions. CD4 + /CD8 + T-cell ratios were normal and infiltrating cells included mast cells, eosinophils, and tumour cells. Our study has described additional patients with confirmed Wolf's isotopic response following herpes zoster infection; moreover, it has extended the spectrum of Wolf's isotopic response to include impetigo. We suggest Wolf's isotopic response classification categories for herpes zoster-associated Wolf's isotopic response. Additionally, clinicians should consider the possibilities of different diseases in Wolf's isotopic response, especially malignancies. ActaDV ActaDV Advances in dermatology and venereologyActa Dermato-Venereologica T. Wang et al. 954 www.medicaljournals.se/acta ActaDV ActaDV Advances in dermatology and venereology Acta Dermato-Venereologica T. Wang et al. 956 www.medicaljournals.se/acta ActaDV ActaDV Advances in dermatology and venereology Acta Dermato-Venereologica T. Wang et al. 958

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Section: Inflammatory Infiltrations In Wolf's Isotopic Responsesupporting

confidence: 92%

Section: Inflammatory Infiltrations In Wolf's Isotopic Responsementioning

confidence: 99%

Section: Mechanism and Pathogenesis Of Wolf's Isotopic Responsementioning

confidence: 99%

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Wolf’s Isotopic Response after Herpes Zoster Infection: A Study of 24 New Cases and Literature Review

Wang

Zhang²,

Zhang³

et al. 2019

Acta Derm Venerol

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“…Furthermore, CD69 deficiency led to a reduction in the generation of CD103 + TRMs in the skin [81]. In human skin, TRMs are possibly involved in Wolf's isotopic response following herpes infection [74].…”

Section: Trms and Skin Infectionsmentioning

confidence: 99%

“…Viral skin infection [14,38,[46][47][48]53,54,[75][76][77][82][83][84][85][86][87][88][90][91][92]105] Herpes simplex virus-1 [18,65,71,[78][79][80]89,93,97,103,[107][108][109][110] Candida albicans [49,54,112] Tick infection [50] Staphylococcus aureus [113] Herpes zoster [74,81] Leishmaniasis [55,56] Psoriasis [27,51,52,[57][58][59]94,…”

Section: Skin Infectionsmentioning

confidence: 99%

Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review

Emmanuel

Mistegård

Bregnhøj

et al. 2021

IJMS

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In health, the non-recirculating nature and long-term persistence of tissue-resident memory T cells (TRMs) in tissues protects against invading pathogens. In disease, pathogenic TRMs contribute to the recurring traits of many skin diseases. We aimed to conduct a systematic literature review on the current understanding of the role of TRMs in skin diseases and identify gaps as well as future research paths. EMBASE, PubMed, SCOPUS, Web of Science, Clinicaltrials.gov and WHO Trials Registry were searched systematically for relevant studies from their inception to October 2020. Included studies were reviewed independently by two authors. This study was conducted in accordance with the PRISMA-S guidelines. This protocol was registered with the PROSPERO database (ref: CRD42020206416). We identified 96 studies meeting the inclusion criteria. TRMs have mostly been investigated in murine skin and in relation to infectious skin diseases. Pathogenic TRMs have been characterized in various skin diseases including psoriasis, vitiligo and cutaneous T-cell lymphoma. Studies are needed to discover biomarkers that may delineate TRMs poised for pathogenic activity in skin diseases and establish to which extent TRMs are contingent on the local skin microenvironment. Additionally, future studies may investigate the effects of current treatments on the persistence of pathogenic TRMs in human skin.

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Lichen plan cutané sur cicatrices d’un syndrome de Stevens-Johnson : réponse isotopique de Wolf

Saka

Akakpo

Teclessou

et al. 2019

Annales de Dermatologie et de Vénéréologie

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Postherpetic Wolf's isotopic response: possible contribution of resident memory T cells to the pathogenesis of lichenoid reaction

Cited by 8 publications

References 9 publications

Wolf’s Isotopic Response after Herpes Zoster Infection: A Study of 24 New Cases and Literature Review

Wolf’s Isotopic Response after Herpes Zoster Infection: A Study of 24 New Cases and Literature Review

Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review

Lichen plan cutané sur cicatrices d’un syndrome de Stevens-Johnson : réponse isotopique de Wolf

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