Posterior Vitreous Detachment Associated with Non-arteritic Ischaemic Optic Neuropathy

Shen, Bailey; MacIntosh, Peter W.

doi:10.1080/01658107.2016.1206575

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…There has been a longstanding speculation about the role of vitreous traction in the pathogenesis of NAION. 15 – 17 A careful examination of the vitreous attachments to the disc on the high definition raster images failed to demonstrate evidence of vitreous traction or partial detachment in this cohort of patients.…”

Section: Discussionmentioning

confidence: 78%

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Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations

Kupersmith

Sibony

Dave

2017

Invest. Ophthalmol. Vis. Sci.

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PurposeWe hypothesized that the edema/swelling in the retina due to acute nonarteritic anterior ischemic optic neuropathy (NAION) can induce retinal folds (RF). We determined the pattern and frequency of folds in NAION at presentation and in follow-up, and the relationship between folds and a number of functional and structural parameters over time.MethodsWe prospectively studied eyes with acute NAION by spectral-domain optic coherence tomography (SD-OCT). We used transaxial and en face views to evaluate the presence of peripapillary fluid (PPF), peripapillary wrinkles (PPW), RF, choroidal folds (CF), creases, macular edema, and vitreous traction on the optic disc. Retinal deformations were correlated with the retinal nerve fiber layer (RNFL) thickness, logMAR visual acuity (VA) and mean deviation (MD).ResultsAt presentation, 60 eyes had mean RNFL = 224 ± 75 μm, no vitreous traction, and similar VA and MD regardless of the retinal deformation or macular edema. There was PPF in 73%, PPW in 57%, RF in 38%, creases in 20%, and macular edema in 18% of eyes, and no CF. Eyes with retinal deformations had significantly greater RNFL thickness (P < 0.026). At 1 to 2 months, 49 eyes had reduction of the RNFL (112 ± 40 μm, P = 0.001) and unchanged VA and MD that did not correlate with fewer eyes having PPF (15%, P = 0.001), PPW (10%, P = 0.001), RF (10%, P = 0.001), creases (17%), and macular edema (0%, P = 0.007).ConclusionsRF in NAION reflect stresses and strains due to extracellular fluid without increased pressure in the retrolaminar tissue and subarachnoid space, seen with papilledema. In NAION, the deformations and their resolution do not correlate with vision loss.

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Section: Discussionmentioning

confidence: 78%

“…Lastly, we evaluated whether vitreous traction on the optic disc is a common contributory factor for NAION. 14 – 17 …”

mentioning

confidence: 99%

Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations

Kupersmith

Sibony

Dave

2017

Invest. Ophthalmol. Vis. Sci.

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“…Despite the widespread use of OCT in clinical evaluation of optic disc edema, there are almost no cases of documented VPT in NAION. Shen and MacIntosh report one case of acute NAION with symptomatic development of ipsilateral PVD 2 weeks later in association with worsening then subsequent improvement of the visual field defect (71). They acknowledge OCT was not performed at presentation to confirm vitreopapillary traction was present at the time of NAION onset.…”

Section: Optical Coherence Tomography Studies Assessing For Vitreopap...mentioning

confidence: 99%

“…Conversely, should vitreous attachments be present with substantial gel still within the hyaloid sac, interventions might be in order (68)(69)(70)(71)(72). Prospective studies determining the likelihood of same eye progression, or of second eye involvement, as a function of vitreous status would be of use.…”

Section: Vitreopapillary Traction Causes Nonarteritic Anterior Ischem...mentioning

confidence: 99%

Does Vitreopapillary Traction Cause Nonarteritic Anterior Ischemic Optic Neuropathy?

Parsa¹,

Williams²,

Stavern

et al. 2021

Journal of Neuro-Ophthalmology

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“…Small optic cup, crowded optic disc, retrovitreal traction, etc. Local risk factors for morbidity [10][11][12]. At present, the treatment of this disease is mainly based on corticosteroids, autonomic regulators, vasodilators, etc.…”

Section: Introductionmentioning

confidence: 99%

Construction and functional enrichment analysis of CeRNA regulatory network for NAION based on high-throughput sequencing

Zhang

Wang

2022

Preprint

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Background: Based on the transcriptome high-throughput sequencing of non arteritis anterior ischemic optic neuropathy, this study constructed a competitive endogenous RNA (CeRNA) network , enriched and analyzed it, screened lncRNA and circRNA that may participate in the competitive endogenous mechanism in NAION, and inferred its function. Methods: 4ml peripheral blood of NAION patients and control group were extracted from clinical samples, and the transcriptome high-throughput sequencing was performed, and the sequencing data were visualized; Based on the principle of CeRNA network, lncRNA-miRNA-mRNA interaction axis and circrna-miRNA-mRNA interaction axis were constructed respectively; The differentially expressed genes in the interaction axis were enriched and analyzed by GO and KEGG, and the functions and signal pathways of lncRNA and circRNA in the interaction network were speculated. Results: 51 circRNAs were differentially expressed in the sequencing data: 25 were up-regulated and 26 were down-regulated; There were 996 differentially expressed lncRNAs: 317 were up-regulated and 679 were down-regulated; 1161 differentially expressed mRNAs: 698 were up-regulated and 463 were down-regulated. 33 differentially expressed miRNAs, up-regulated mirna18 and down-regulated 15. After screening, the co-expressed 13 mRNAs, 15 lncRNAs and 3 miRNAs were finally constructed in lncRNA-miRNA-mRNA network and the circRNA-miRNA-mRNA network were constructed by 159 mRNAs, 26 miRNAs and 34 circRNAs. In the lncRNA network , GO enrichment analysis obtained 182 biological processes, 12 cell components and 38 molecular functions, which are mainly related to the activity regulation of proteins and enzymes such as cyclic nucleotide dependent protein kinase activity and magnesium ion dependent protein serine / threonine phosphatase activity. KEGG analysis mainly involves FOXO signal pathway, Apelin signal pathway, etc. In the result of circRNA enrichment, 353 biological processes, 52 cell components and 45 molecular functions were obtained, mainly involving calcium channel regulation, neutrophil activation, mRNA transport and metabolism. KEGG mainly involves Wnt signaling pathway, Apelin signaling pathway, Hippo signaling pathway, oxytocin signaling pathway, etc. Conclusion: This paper provides a new idea for lncRNA and circRNA to mediate the occurrence and development of NAION through CeRNA mechanism. It lays a foundation for the in-depth study of pathogenesis of NAION.

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Posterior Vitreous Detachment Associated with Non-arteritic Ischaemic Optic Neuropathy

Cited by 5 publications

References 5 publications

Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations

Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations

Does Vitreopapillary Traction Cause Nonarteritic Anterior Ischemic Optic Neuropathy?

Construction and functional enrichment analysis of CeRNA regulatory network for NAION based on high-throughput sequencing

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