Posterior uveal melanoma in 321 Asian Indian patients: analysis based on the 8th edition of American Joint Committee Cancer classification

Kapoor, Anasua Ganguly; Kaliki, Swathi; Vempuluru, Vijitha S; Jajapuram, Sai Divya; Ali, Mohammed; Mohamed, Ashik

doi:10.1007/s10792-020-01494-2

Cited by 8 publications

(4 citation statements)

References 16 publications

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“…19 In this study we investigated speci c skin tones, regardless of race, and found similar results that FST types III-V were associated with greater tumor thickness and larger basal diameter, as compared to FST type I and II. This nding correlates with the results from the Asian Indian reports as the majority of Asian Indians in our study were classi ed as FST type III-V. 9,10,19 Caucasians and Northern Europeans with blue or green irides present more commonly with UM than those with brown iris color. [11][12][13] In our study, we examined the relationship of individual iris color with tumor thickness and tumor basal diameter and found no association between these factors.…”

Section: Discussionmentioning

confidence: 52%

“…10 Kapoor et al studied 321 Asian Indian patients with posterior UM based on the 8th edition of AJCC classi cation and noted that the majority (66%) of patients belonged to the T3 (39%) or T4 (27%) categories. 19 In that study, Asian Indians demonstrated a higher AJCC T category compared to Shields et al study of 7554 Caucasians with UM (T3 39% vs. 20.4% and T4 27% vs. 6.3% ). 19 In this study we investigated speci c skin tones, regardless of race, and found similar results that FST types III-V were associated with greater tumor thickness and larger basal diameter, as compared to FST type I and II.…”

Section: Discussionmentioning

confidence: 62%

“…19 In that study, Asian Indians demonstrated a higher AJCC T category compared to Shields et al study of 7554 Caucasians with UM (T3 39% vs. 20.4% and T4 27% vs. 6.3% ). 19 In this study we investigated speci c skin tones, regardless of race, and found similar results that FST types III-V were associated with greater tumor thickness and larger basal diameter, as compared to FST type I and II. This nding correlates with the results from the Asian Indian reports as the majority of Asian Indians in our study were classi ed as FST type III-V. 9,10,19 Caucasians and Northern Europeans with blue or green irides present more commonly with UM than those with brown iris color.…”

Section: Discussionmentioning

confidence: 62%

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Correlation of Fitzpatrick Skin Type and Iris Color with Tumor Size in 823 patients with Uveal Melanoma

Agrawal

Barke²,

Chiang³

et al. 2023

Preprint

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Objective: To determine the correlation of Fitzpatrick Skin Type (FST) and iris color with tumor size (tumor thickness and basal diameter) in patients with uveal melanoma. Methods: Retrospective cohort from a single ocular oncology center of 823 patients with uveal melanoma and documented FST, iris color, and tumor size. Patients were classified into FST (type I, II, and III-V) and iris color (blue, green, and brown) on the basis of external facial photography. There were no FST type VI patients. Tumor thickness was classified into small [<3 millimeter (mm)], medium (3.1-8.0 mm), or large (>8.0 mm), and basal diameter into small (<10 mm), medium (10.1-15 mm) or large (>15mm). The correlation of FST and iris color with tumor thickness and basal diameter was evaluated using the Kruskal-Wallis H test. Results: The FST classification was type I (n=92, 11%), type II (n=643, 78%), or III-V (n=88, 11%), and iris color was blue (n=472, 57%), green (n=102, 12%), or brown (n=249, 30%). A comparison of FST revealed differences in mean tumor thickness (p= 0.04) and basal diameter (p=0.006). Iris color showed no difference for mean tumor thickness (p=0.41) or basal diameter (p=0.48). There was a difference with brown iris color relative to FST III-V for mean tumor thickness (p=0.003) and basal diameter (p=0.001) but no difference with blue or green iris color (p > 0.05). Conclusions: Iris color alone showed no difference in tumor size, but those with brown iris color and FST type III-V demonstrated larger tumor thickness and basal diameter.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 62%

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Correlation of Fitzpatrick Skin Type and Iris Color with Tumor Size in 823 patients with Uveal Melanoma

Agrawal

Barke²,

Chiang³

et al. 2023

Preprint

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“…et al studied the accuracy of the 8th edition of the AJCC Classification on Asian Indians and found later presentation with more T3 (39%) and T4 cases (26%) and a lower mean age of presentation [26]. Distant metastasis estimates at 5 years were 0%, 0%, 7%, and 13% for T categories T1-4, and the survival rates were 96%, 92%, 81%, and 70% [26]. These values were noted by the authors to be higher than those seen in Caucasian populations, as seen in studies such as Shields CL.…”

Section: Clinical Validation Findings Of the American Joint Committee...mentioning

confidence: 99%

Pathological and Molecular Diagnosis of Uveal Melanoma

Păsărică,

Curcă,

Dragosloveanu

et al. 2024

Diagnostics

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(1) Background: Uveal melanoma (UM) is a common malignant intraocular tumor that presents with significant genetic differences to cutaneous melanoma and has a high genetic burden in terms of prognosis. (2) Methods: A systematic literature search of several repositories on uveal melanoma diagnosis, prognosis, molecular analysis, and treatment was conducted. (3) Results: Recent genetic understanding of oncogene-initiation mutations in GNAQ, GNA11, PLCB4, and CYSLTR2 and secondary progression drivers of BAP1 inactivation and SF3B1 and EIF1AX mutations offers an appealing explanation to the high prognostic impact of adding genetic profiling to clinical UM classification. Genetic information could help better explain peculiarities in uveal melanoma, such as the low long-term survival despite effective primary tumor treatment, the overwhelming propensity to metastasize to the liver, and possibly therapeutic behaviors. (4) Conclusions: Understanding of uveal melanoma has improved step-by-step from histopathology to clinical classification to more recent genetic understanding of oncogenic initiation and progression.

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Diagnostic utility of immunohistochemistry in concordance with mRNA analysis of PRAME in the stratification of high-risk uveal melanoma patients

Kumar

Singh

et al. 2022

Human Cell

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Posterior uveal melanoma in 321 Asian Indian patients: analysis based on the 8th edition of American Joint Committee Cancer classification

Cited by 8 publications

References 16 publications

Correlation of Fitzpatrick Skin Type and Iris Color with Tumor Size in 823 patients with Uveal Melanoma

Correlation of Fitzpatrick Skin Type and Iris Color with Tumor Size in 823 patients with Uveal Melanoma

Pathological and Molecular Diagnosis of Uveal Melanoma

Diagnostic utility of immunohistochemistry in concordance with mRNA analysis of PRAME in the stratification of high-risk uveal melanoma patients

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