Posterior staphylomas in non-highly myopic eyes with retinitis pigmentosa

Pazo

et al. 2022

Korean J Ophthalmol

Title: Factors Associated with Macular Staphyloma Area on Ultra-widefield Fundus ImagesPurpose: To assess the feasibility of applying ultra-widefield fundus (UWF) images for macular staphyloma area (MSA) measurement, and investigate the associated factors with MSA.Methods: This is a retrospective study. MSA was measured by UWF imaging. Central foveal thickness (CFT), subfoveal choroidal thickness (SFCT), subfoveal scleral thickness (SFST) were measured on spectral-domain optical coherence tomography. Intraclass correlation coefficients (ICC) of MSA measurement would be evaluated. Multiple linear regression analysis was used to analyse the associated factors with MSA. Results:In total 135 eyes of 92 patients were enrolled. The mean age was 64.73±10.84 years. Mean MSA on UWF image was 279.67±71.70 mm2. Intraclass correlation coefficients (ICC) of MSA measurement was 0.965 (95% confidence interval (CI), 0.946-0.977; p<0.001). In the multiple linear regression analysis, after adjusting for SFCT, BCVA, CFT, SFST, the factors independently related to MSA were axial length (AL) (β=8.352; 95% CI, p=0.001), sex (β=-26.673; 95% CI, -51.759--1.586; p=0.037), age (β=1.184; 95% CI, 0.020-2.348; p=0.046). Conclusions: It is feasible to measure MSA on UWF image. Female, longer AL, older age may indicate larger area of macular staphyloma.

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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Factors Associated with Macular Staphyloma Area on Ultra-widefield Fundus Images

Pazo

et al. 2022

Korean J Ophthalmol

“…Their OCT features and choroidal profile were also similar [10]. Matri, et al, studied 77 eyes of 39 retinitis pigmentosa patients and found posterior staphyloma in 17 eyes of 9 patients (all being non high myopes) [11]. 15 eyes had a narrow macular staphyloma and 2 eyes had a wide macular staphyloma.…”

Section: Discussionmentioning

confidence: 71%

Retinitis Pigmentosa, Staphyloma and Myopia Syndrome-A Rare Entity

Azad¹,

Bhayana²,

Balaji³

2021

JOAR

Retinitis Pigmentosa (RP) is a common retinal dystrophy which causes progressive vision loss. Waxy disc pallor, arteriolar attenuation with mid-peripheral bony spicules form characteristic triad of the disease. Beginning as nyctalopia, the disease progresses to cause significant vision loss and visual field defect. Pathological myopia, staphyloma and cataract may be associated with the disorder as spectrum of MRCS syndrome which has a varied phenotypic presentation. We would like to report one such case.

“…The histological and biomechanical properties of the sclera may play an important role in the occurrence of PS. However, these theories are still insufficient to fully explain the pathogenesis of PS in high myopic eyes, because the PS was also observed in some patients without high myopia ( Xu et al, 2019 ; El Matri et al, 2020 ). Whether anti-hypoxic drugs can be applied to inhibit scleral thinning and control the development of myopia needs further study.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Macular Structural and Microcirculatory Characteristics of Posterior Staphyloma in High Myopic Eyes by Swept Source Optical Coherence Tomography Angiography

Wang

Liu

et al. 2022

Front. Physiol.

Purpose: To investigate the characteristics of macular structures and microcirculation of posterior staphyloma (PS) and explored factors related to PS in eyes with high myopia.Methods: There were 114 eyes of 82 patients in this study. Using 1:1 matching of the axial length of myopic eyes, patients were divided into no PS (NPS) and PS groups. Comprehensive ophthalmic examinations were performed on all patients. Structural parameters were acquired using swept source optical coherence tomography (SS-OCT). OCT angiography (OCTA) was used to measure the microcirculation parameters. Generalized estimated equation and linear correlation analysis were used for the statistical analysis.Results: Patients with PS had a thinner retinal thickness (RT) and choroid thickness (CT) (all p < 0.05) in the measurement areas and a significantly lower subfoveal scleral thickness (SFST) (p < 0.001) than those without PS. Retinal deep vascular complex density (DVD) (all p < 0.05) and choriocapillaris perfusion area (CCPA) (all p < 0.001) were significantly lower in the measurement areas of the PS group than in those of the NPS group. There was no significant difference in the retinal superficial vascular density between the two groups. Generalized estimating equation indicated that SFST (B = 0.079, p = 0.001), parafoveal RT (B = −0.162, p = 0.041), foveal CT (B = 0.292, p = 0.013), parafoveal CT (B = −0.157, p = 0.023), foveal CCPA (B = 0.691, p = 0.003) and parafoveal CCPA (B = −0.026, p = 0.004) were significantly correlated with PS. Age (r = −0.323, p = 0.001), spherical equivalent refraction (SER) (r = 0.289, p = 0.004), subfoveal CT (r = 0.398, p < 0.001), foveal DVD (r = 0.346, p < 0.001), foveal CT (r = 0.429, p < 0.001), and foveal CCPA (r = 0.387, p < 0.001) were strongly correlated with SFST.Conclusions: The macular structures and microcirculation in the PS group were different from those in the NPS group. SFST, CT, and CCPA were significantly correlated with PS. Lower SFST in PS was correlated with abnormalities of CT and microcirculation.