Posterior Reversible Leukoencephalopathy Syndrome with Rotavirus Gastroenteritis

Çelik, Tamer; Çelik, Ümit

doi:10.5152/ced.2015.1686

Cited by 2 publications

(1 citation statement)

References 13 publications

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“… 27 Infectious diseases such as meningitis, acute gastro-enteritis (AGE), malaria, pneumonia, sepsis, and septic shock have been identified as the commonest causes of admission into emergency wards in Nigeria, 22 , 23 have also been implicated in the etiology of PRES. 46 - 51 These have sometimes also been misdiagnosed as PRES. 41 - 43 Other authors have also identified epileptic seizures, encephalopathy, visual deficits, hypertension, chemotherapy, and renal failure as best predictors of PRES in children.…”

Section: Current Status Of Knowledgementioning

confidence: 99%

Challenges of Diagnosing Pediatric Posterior Reversible Encephalopathy Syndrome in Resource Poor Settings: A Narrative Review

Ndu

Ayuk

Onukwuli

2020

Global Pediatric Health

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Posterior reversible encephalopathy syndrome (PRES) is a rare clinical syndrome that has been observed in different age groups, including pediatric patients. Identified triggers of PRES in both children and adults have included immunosuppressive and cytotoxic agents, organ transplantation, severe sepsis, blood transfusion, or evidence of human immunodeficiency virus-1 (HIV-1). Its clinical and radiological courses have been reported as mostly benign and reversible over days to weeks. Computed tomography (CT) scans are helpful in diagnosis, but magnetic resonance imaging (MRI) remains the gold standard. Unfortunately, because of the prohibitive costs of such medical equipment, diagnosis remains a challenge in developing countries. There is a dearth of information about pediatric PRES in resource–poor settings. This narrative aims to draw attention to the possible existence of PRES in children and to identify factors responsible for the difficulty in making the diagnosis. This review will hopefully increase awareness of PRES among pediatricians in order to make early diagnosis and institute appropriate management of this condition.

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Section: Current Status Of Knowledgementioning

confidence: 99%

Challenges of Diagnosing Pediatric Posterior Reversible Encephalopathy Syndrome in Resource Poor Settings: A Narrative Review

Ndu

Ayuk

Onukwuli

2020

Global Pediatric Health

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Rotavirus Infection-Associated Posterior Reversible Encephalopathy Syndrome

Lee

Kim

2019

Ann Child Neurol

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Rotavirus is an important cause of severe gastroenteritis in infants and children. Generally, rotavirus infections are self-limiting benign diseases but occasionally can cause a wide range of neurological manifestations, including benign febrile or afebrile convulsions, meningoencephalitis, cerebellitis, and lethal encephalitis or encephalopathy [1]. However, it is unclear how rotavirus can affect the central nervous system without direct invasion. Posterior reversible encephalopathy syndrome (PRES) is a well-recognized clinical disorder with typical neuroimaging findings consisting of mostly transient bilateral gray and white matter abnormalities in the posterior cerebral hemispheric regions and cerebellum [2]. The common clinical symptoms are headache, confusion, seizures, and visual disturbances such as cortical blindness. These symptoms usually recover without sequelae following appropriate treatment. Common precipitants are sudden elevations of blood pressure, renal failure, fluid restriction, and treatment with immunosuppressive drugs such as cyclosporine [3]. Recently, studies related to infection-associated PRES have been published [2,4]. We describe the case of a 6-year-old boy with rotavirus gastroenteritis who developed clinical and radiological manifestations consistent with PRES.

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Posterior Reversible Leukoencephalopathy Syndrome with Rotavirus Gastroenteritis

Cited by 2 publications

References 13 publications

Challenges of Diagnosing Pediatric Posterior Reversible Encephalopathy Syndrome in Resource Poor Settings: A Narrative Review

Challenges of Diagnosing Pediatric Posterior Reversible Encephalopathy Syndrome in Resource Poor Settings: A Narrative Review

Rotavirus Infection-Associated Posterior Reversible Encephalopathy Syndrome

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