Posterior reversible encephalopathy syndrome: Some novel associations

Nandi, Madhumita; Sarkar, Sumantra; Mondal, Rakesh; Dhibar, Tapan

doi:10.7196/sajch.2015.v9i4.934

Cited by 2 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When compared to the high income countries also, poverty and poor clinical settings in LMIC contributes to the diagnostic challenges and may contribute to limited research interest in pediatric PRES with consequent underreporting of PRES 67 - 69 Most of the reports of pediatric PRES have been from developed countries 2 , 4 , 10 - 21 and a few from Africa. Nandi and colleagues 70 in South Africa were able to diagnose PRES in 4 children with novel aetiological associations: hypoxia following accidental strangulation, near-drowning episode, a child with thalassaemia receiving routine blood transfusions, and a fourth child who had PRES while recovering from toxic epidermal necrolysis syndrome (TENS). These all presented in such a way that the diagnosis of PRES would have been missed easily.…”

Section: Current Status Of Knowledgementioning

confidence: 99%

Challenges of Diagnosing Pediatric Posterior Reversible Encephalopathy Syndrome in Resource Poor Settings: A Narrative Review

Ndu

Ayuk

Onukwuli

2020

Global Pediatric Health

View full text Add to dashboard Cite

Posterior reversible encephalopathy syndrome (PRES) is a rare clinical syndrome that has been observed in different age groups, including pediatric patients. Identified triggers of PRES in both children and adults have included immunosuppressive and cytotoxic agents, organ transplantation, severe sepsis, blood transfusion, or evidence of human immunodeficiency virus-1 (HIV-1). Its clinical and radiological courses have been reported as mostly benign and reversible over days to weeks. Computed tomography (CT) scans are helpful in diagnosis, but magnetic resonance imaging (MRI) remains the gold standard. Unfortunately, because of the prohibitive costs of such medical equipment, diagnosis remains a challenge in developing countries. There is a dearth of information about pediatric PRES in resource–poor settings. This narrative aims to draw attention to the possible existence of PRES in children and to identify factors responsible for the difficulty in making the diagnosis. This review will hopefully increase awareness of PRES among pediatricians in order to make early diagnosis and institute appropriate management of this condition.

show abstract

Section: Current Status Of Knowledgementioning

confidence: 99%

Challenges of Diagnosing Pediatric Posterior Reversible Encephalopathy Syndrome in Resource Poor Settings: A Narrative Review

Ndu

Ayuk

Onukwuli

2020

Global Pediatric Health

View full text Add to dashboard Cite

show abstract

Posterior reversible encephalopathy syndrome in a known case of beta-thalassemia major after blood transfusion: a case presentation

Hanna,

Nada,

Gohary

2024

Egypt Pediatric Association Gaz

View full text Add to dashboard Cite

Background Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic condition associated with a distinctive brain imaging pattern which typically occur in some complex clinical conditions. However, the leading offender to this condition remains not clear. Case presentation We report a 6-year-old female with β-thalassemia major presenting with generalized tonic–clonic convulsions, repeated attacks of projectile vomiting, blurred vision, and altered conscious level after blood transfusion. The brain magnetic resonance imaging (MRI) FLAIR sequence revealed bilateral and symmetrical subcortical edema displaying high signal intensity. Follow-up MRI 1 month later showed complete resolution of the previously identified findings. The clinical presentation along with neuroimaging pattern as well as the reversible course indicated PRES as the most suitable diagnosis. Although PRES has been previously described in different clinical settings, this is a rare case of PRES recognized after blood transfusion in a child with β-thalassemia major. Conclusion Acute neurological symptoms in children with thalassemia should raise high suspicion for PRES, especially after blood transfusion.

show abstract

Posterior reversible encephalopathy syndrome: Some novel associations

Cited by 2 publications

References 9 publications

Challenges of Diagnosing Pediatric Posterior Reversible Encephalopathy Syndrome in Resource Poor Settings: A Narrative Review

Challenges of Diagnosing Pediatric Posterior Reversible Encephalopathy Syndrome in Resource Poor Settings: A Narrative Review

Posterior reversible encephalopathy syndrome in a known case of beta-thalassemia major after blood transfusion: a case presentation

Contact Info

Product

Resources

About