Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis

Oliveira, Rodrigo Alves de; Fechine, Lílian Magalhães; Neto, Francisco Costa; Nicodemus, José Marcílio; Silva, Geraldo Bezerra da; Silva, Leila S V

doi:10.1007/s11255-008-9431-y

Cited by 23 publications

(18 citation statements)

References 10 publications

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“…This finding has been corroborated in case reports that described complex partial seizures and even myoclonic jerks in NBD [13][14][15]. The use of cyclosporin could be related to the occurrence of seizures due to neurotoxicity, mainly causing posterior reversible encephalopathy [16,17]. However, none of the patients studied received this immunosuppressant.…”

Section: Discussionsupporting

confidence: 55%

Epilepsy and Behçet's disease: Cortical and hippocampal involvement in Brazilian patients

Dutra

Braga‐Neto

Pedroso

et al. 2011

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 55%

Epilepsy and Behçet's disease: Cortical and hippocampal involvement in Brazilian patients

Dutra

Braga‐Neto

Pedroso

et al. 2011

Journal of the Neurological Sciences

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“…PRES in association with nephrotic syndrome secondary to FSGS is rare6 and we found only three reported cases of PRES in association with FSGS 6 8 9. All the three patients were in their 20s and presented with uncontrolled hypertension, seizures, headache and visual changes.…”

Section: Discussionmentioning

confidence: 78%

Posterior reversible encephalopathy syndrome in malignant hypertension secondary to focal segmental glomerulosclerosis

et al. 2016

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Posterior reversible encephalopathy syndrome (PRES) is a neurological condition that occurs secondary to a variety of causes like autoimmune diseases, uncontrolled hypertension and immunosuppressive agents. We report an unusual association of PRES and malignant hypertension secondary to focal segmental glomerulosclerosis in a young woman, presenting with sudden loss of vision and seizures. She had uncontrolled hypertension and a Glasgow Coma Scale of 6/15. Brain MRI revealed high signals in cortical and subcortical white matter and some involvement of the periventricular areas. She improved dramatically with antihypertensive and antiepileptic medications and was discharged home in a stable condition. It is important to have a high clinical suspicion for this uncommon condition in an appropriate clinical setting, because a timely intervention can prevent long-term complications.

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“…PRES most often occurs in the setting of hypertensive crisis, preeclampsia, or with cytotoxic immunosuppressive therapy; however, many other clinical settings are described. [345678910]…”

Section: Discussionmentioning

confidence: 99%

“…[34567] It could be induced by cyclosporine use in a patient with kidney disease or occurring after blood transfusion in a patient with CKD. [89] Recurrent and atypical posterior reversible encephalopathy syndrome in a child with peritoneal dialysis has been reported. [10] We report successful renal transplantation (RTx) in a CKD patient with PRES.…”

Section: Introductionmentioning

confidence: 99%

Posterior reversible encephalopathy syndrome-an under recognized manifestation of Chronic Kidney Disease

Kute¹,

Trivedi²,

Shah³

et al. 2013

Indian Journal of Critical Care Medicine

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First Report of the Indian Chronic Kidney Disease (CKD) Registry showed that patient with CKD in India more frequently presented in Stage V. Many patients have uncontrolled hypertension and uremia due to noncompliance or non affordability of renal replacement therapy which can lead to complications such as posterior reversible encephalopathy syndrome (PRES). A 17-year-old female had end stage renal disease (ESRD) due to malignant hypertension. She developed headaches, altered consciousness, visual disturbances and seizures. A non contrast brain computed tomography revealed bilateral symmetrical white matter hypodensity in parietal, temporal, and occipital region suggesting PRES. Intravenous lorazepam was given for acute control of seizure and she required phenytoin, valproic acid, levetiracetam to control seizures. She was started on more frequent hemodialysis. She required five types of antihypertensive drugs to control blood pressure. We report successful renal transplantation (RTx) in a CKD patient with PRES. Constraints in operating an effective maintenance dialysis program leave RTx as the only viable option for ESRD patients in our country to prevent complications like PRES associated with uremia and uncontrolled hypertension

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Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis

Abstract: PRES is a rare syndrome that must be suspected in every patient presenting neurologic symptoms in the course of immunosuppression. It can be induced by CSA and is totally reversible when the drug is rapidly withdrawn.

Cited by 23 publications

References 10 publications

Epilepsy and Behçet's disease: Cortical and hippocampal involvement in Brazilian patients

Epilepsy and Behçet's disease: Cortical and hippocampal involvement in Brazilian patients

Posterior reversible encephalopathy syndrome in malignant hypertension secondary to focal segmental glomerulosclerosis

Posterior reversible encephalopathy syndrome-an under recognized manifestation of Chronic Kidney Disease

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