Posterior Reversible Encephalopathy Syndrome: More Than Meets the Eye

Munoz, Javier; Kumar, Vinodh A.; Hamilton, Jackson; Pasche, Lezlee Jean; Langford, Lauren A.; Taggart, Melissa W.; Kamiya-Matsuoka, Carlos; Tummala, Sudhakar; Moulder, Stacy L.; Kurzrock, Razelle

doi:10.1200/jco.2012.46.6573

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…No description of long term chemotherapy management was documented. The third case of PRES presented in a 55‐year‐old female with metastatic breast cancer on anastrozole only . Her last cytotoxic regimen included protein‐bound paclitaxel and bevacizumab, which had been discontinued after disease progression approximately 15 months before her presentation.…”

Section: Discussionmentioning

confidence: 99%

Posterior Reversible Encephalopathy Syndrome in Early-Stage Breast Cancer

et al. 2015

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Wider use of chemotherapy and targeted agents can be associated with posterior reversible encephalopathy syndrome (PRES). This syndrome is most commonly found in metastatic adenocarcinoma treated with platinum-based analogs and is managed with cessation of the precipitating medication. We present the first case of PRES in early-stage breast cancer and discuss the further management of this condition. Recognition of this condition and correction of identifiable precipitating factor including cessation of relevant medications remains important in its management.

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Section: Discussionmentioning

confidence: 99%

Posterior Reversible Encephalopathy Syndrome in Early-Stage Breast Cancer

et al. 2015

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“…70 PRES typically resolves when the causative drug is withheld, but residual deficits from infarction or hemorrhage are more common in cancer patients. 76 …”

Section: Confusion: Indirect Relation To Cancer Treatmentmentioning

confidence: 99%

The confused oncologic patient: a rational clinical approach

Nolan

DeAngelis

2016

Current Opinion in Neurology

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Purpose of review The purpose of this review is to provide a practical clinical approach to confusion in the patient with cancer. Confusion in the cancer population has a broader differential diagnosis than in the general medical population. The clinician must consider the usual differential diagnoses as well as causes unique to the cancer patient including direct complications from the cancer and indirect complications related to cancer treatment. Recent findings In the recent age of precision medicine, the oncologist now utilizes the genomic profile of both the patient and the tumor to provide advanced biologic therapies including targeted anticancer drugs, antiangiogenic agents, and immunotherapy. Such advances carry with them an emerging pattern of neurotoxicity which, although less well described in the literature, is now an important consideration to the clinical approach to confusion in cancer patients. Summary Confusion is the most common neurologic complication in cancer and is associated with significant morbidity, mortality, and prolonged hospital stays resulting in increased health care costs. Early recognition and treatment of delirium is essential to improve clinical outcomes.

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“…2 The occurrence of signs and symptoms in PRES is variable, can occur as early as within an hour to 3 months after the exposure to the insult. 3 The common etiologies of PRES are hypertension, systemic infections, organ transplants, autoimmune diseases (SLE) malignant tumors, chemotherapy and immuno-suppression. 4 The main pathology of PRES is vasogenic edema leading to white matter changes in neuroimaging.…”

Section: Introductionmentioning

confidence: 99%

Posterior Reversible Encepalopathy Syndrome in A Child With Post Streptococcal Glomerulonephritis- A Rare Case Report

et al. 2021

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Posterior reversible encephalopathy syndrome is a condition occurring in majority of case of hypertensive encephalopathy mainly due to vasogenic edema in parieto occipital region in neuroimaging. It is reversible if timely treatment is done .Here we are reporting a 11 year old female child with acute post streptococal glomerulonephrtitis leading to typical clinical and radiological features of posterior reversible encephalopathy syndrome

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Posterior Reversible Encephalopathy Syndrome: More Than Meets the Eye

Cited by 10 publications

References 8 publications

Posterior Reversible Encephalopathy Syndrome in Early-Stage Breast Cancer

Posterior Reversible Encephalopathy Syndrome in Early-Stage Breast Cancer

The confused oncologic patient: a rational clinical approach

Posterior Reversible Encepalopathy Syndrome in A Child With Post Streptococcal Glomerulonephritis- A Rare Case Report

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