Posterior Reversible Encephalopathy Syndrome in a Patient With Newly Diagnosed Systemic Lupus Erythematosus and Thrombotic Thrombocytopenic Purpura

Posterior Reversible Leukoencephalopathy Syndrome in a patient after second dose of Rituximab for treatment of resistant Thrombotic Thrombocytopenic Purpura

“…It has been reported in patients of all age groups and is mostly associated with hypertension (with a mean systolic pressure of 187 mmHg), though the level does not correlate with the severity of symptoms of PRES [2]. Besides hypertension, pre-eclapmsia, eclampsia, sepsis [3], thrombocytopenic thrombotic purpura [4], use of immunosuppressive drugs (most commonly cyclosporine and tacrolimus), cytotoxic agents and many other drugs are also associated with PRES [5].…”

“…It can be complicated by cerebral ischemia and hemorrhage [2]. Treatment includes tight control of blood pressure and seizures, holding the responsible drug, and plasmapheresis in cases associated with TTP [2,4].…”