Posterior Reversible Encephalopathy Syndrome caused by TS-1 plus Cisplatin Combination Therapy of Advanced Gastric Cancer: Report of a Case

孝祐, 戸田; 直樹, 柿原; 賢, ゆう; 亘, 石井; 圭吾, 山田; 克己, 下村; 博臣, 松村; 雅晴, 大垣; 圭悟, 宮田; 温, 竹中

doi:10.5833/jjgs.43.365

Cited by 2 publications

(1 citation statement)

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“…According to the research conducted by the Ministry of Health, Labor and Welfare, the incidence of PRES was about 0.026% between 1982 and 1995. When we performed a literature search in the database of the Japan Medical Abstracts Society using the keywords of leukoencephalopathy and S-1, only the report of Toda et al [ 5 ] was found. On the other hand, when we performed a literature search in the Pharmaceuticals and Medical Devices Agency (PMDA), there were 58 reports on leukoencephalopathy caused by S-1 between 2004 and 2017.…”

Section: Discussionmentioning

confidence: 99%

Posterior reversible encephalopathy syndrome (PRES) caused by chemotherapy containing S-1 against diffuse type gastric cancer

Yokota

Shirai

Sano

et al. 2020

Clin J Gastroenterol

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A 23-year-old woman who complained of abdominal distension and anorexia was referred to our hospital. Computed tomography showed ascites, a huge hepatic tumor and ovarian tumor. Gastroscopy revealed type 4 gastric cancer and biopsy examination showed poorly differentiated adenocarcinoma with signet ring cell carcinoma. We diagnosed her with stage IV advanced gastric adenocarcinoma. She received the chemotherapy with S-1 and CDDP regimen. After two courses, this regimen was changed to the SOX (S-1 + OHP) regimen because of acute kidney injury. After one course of the SOX regimen, she developed general muscle cramp. Magnetic resonance imaging showed a 15 mm, round, high-intensity signal at the parietal lobe on T2-weighted images. She was hospitalized for with the suspicion of brain metastasis. Anticonvulsants improved her muscle cramp, but she had consciousness disturbance on the 9th hospital day. T2WI showed high-intensity signals within the cerebral white matter at both sides of the occipital lobe. We suspected leukoencephalopathy caused by S-1 and discontinued the SOX regimen. We also treated her hypertension and hyponatremia. Her consciousness disturbance improved in several days, and the T2WI finding was markedly improved on the 20th hospital day. We diagnosed her with posterior reversible encephalopathy syndrome caused by chemotherapy containing S-1.

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Section: Discussionmentioning

confidence: 99%