Posterior reversible encephalopathy syndrome associated with SARS-CoV-2 infection

Djellaoui, Abdenour; Seddik, Lilia; Langavant, Laurent Cléret de; Cattan, Samuel; Bachoud-Lévi, A C; Hosseini, Hassan

doi:10.1136/jnnp-2020-323923

Cited by 10 publications

(30 citation statements)

References 4 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CSF oligoclonal bands were tested in 114 patients who did not have a positive CSF SARS-CoV-2 PCR or positive CSF antibodies to SARS-CoV-2 (103 (90%) who had symptoms that localized to the CNS and 11 (10%) who had symptoms that localized to the PNS) [ 9 , 10 , 19 , 20 , 35 , 36 , 42 , 44 , 45 , 58 , 69 , 74 , 79 , 81 , 101 , 112 , 113 , 116 , 117 , 126 , 127 , 130 , 135 , 136 , 147 , 149 , 152 , 154 , 160 , [168] , [169] , [170] , [171] , 177 , 181 , 182 , [185] , [186] , [187] , [188] , 191 , 194 , 203 , 205 , 207 , 209 , 212 , 213 , 215 , 216 , 218 , 233 , 242 , 245 ]. Of these, 35 (31%) had matched CSF and serum bands [ 9 , 35 , 79 , 112 , 113 , 127 , 147 , 170 , 171 , …”

Section: Resultsmentioning

confidence: 99%

“…A paucity of patients in this cohort had a positive CSF SARS-CoV-2 PCR; of 303 patients who had SARS-CoV-2 PCR tested in the CSF, 17 (6%) patients, all of whom had symptoms that localized to the CNS, had a positive result and an additional 3 (1%) had an indeterminate result [5-10,15,17,22,24,26-38, 43-59,68-71,73,74,76-78,81,84,88,89,95,97,98,101,103,105,108, 109,111,113,116,119,122,123,125,127-129,131,134-144,147-150, 152,154,156,157,161,164,165,169,171,177,178,180-182,184-187, 190,191,193,195-201,203,204,205-207,209,212-216,218-221, 224-227,230,233-238,240-246]. Furthermore, only 14/252 (6%) patients who had direct or indirect evaluation for CSF SARS-CoV-2 antibodies (oligoclonal bands or immunoglobulins), had evidence of intrathecal antibody synthesis [6,9,10,13,19,20,25,31,35,36,[42][43][44][45][46]49,57,58,62,69,74,79,81,98,101,112,113,116,117,119,126,127,130,135,136,141,[147][148][149]152,…”

Section: Discussionmentioning

confidence: 99%

Section: Csf Oligoclonal Bandsmentioning

confidence: 99%

See 2 more Smart Citations

Cerebrospinal fluid in COVID-19: A systematic review of the literature

Lewis

Frontera

Placantonakis

et al. 2021

Journal of the Neurological Sciences

150

152

View full text Add to dashboard Cite

We sought to review the literature on cerebrospinal fluid (CSF) testing in patients with COVID-19 for evidence of viral neuroinvasion by SARS-CoV-2. Methods: We performed a systematic review of Medline and Embase between December 1, 2019 and November 18, 2020 to identify case reports or series of patients who had COVID-19 diagnosed based on positive SARS-CoV-2 polymerase chain reaction (PCR) or serologic testing and had CSF testing due to a neurologic symptom. Results: We identified 242 relevant documents which included 430 patients with COVID-19 who had acute neurological symptoms prompting CSF testing. Of those, 321 (75%) patients had symptoms that localized to the central nervous system (CNS). Of 304 patients whose CSF was tested for SARS-CoV-2 PCR, there were 17 (6%) whose test was positive, all of whom had symptoms that localized to the central nervous system (CNS). The majority (13/17, 76%) of these patients were admitted to the hospital because of neurological symptoms. Of 58 patients whose CSF was tested for SARS-CoV-2 antibody, 7 (12%) had positive antibodies with evidence of intrathecal synthesis, all of whom had symptoms that localized to the CNS. Of 132 patients who had oligoclonal bands evaluated, 3 (2%) had evidence of intrathecal antibody synthesis. Of 77 patients tested for autoimmune antibodies in the CSF, 4 (5%) had positive findings. Conclusion: Detection of SARS-CoV-2 in CSF via PCR or evaluation for intrathecal antibody synthesis appears to be rare. Most neurological complications associated with SARS-CoV-2 are unlikely to be related to direct viral neuroinvasion.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Csf Oligoclonal Bandsmentioning

confidence: 99%

See 1 more Smart Citation

Cerebrospinal fluid in COVID-19: A systematic review of the literature

Lewis

Frontera

Placantonakis

et al. 2021

Journal of the Neurological Sciences

150

152

View full text Add to dashboard Cite

show abstract

“…SARS-CoV-2 PCR testing was performed in the CSF for 45/69 (65%) patients [ [3] , [4] , [5] , [6] , [7] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , 18 , 28 , [31] , [32] , [33] , [34] , [35] , [36] , [37] , 39 , 41 , 42 , 45 , [50] , [51] , [52] , [53] , 55 , 56 , 59 , 60 , 63 , 64 ]. Of these, 6/45 (13%) had a positive CSF SARS-CoV-2 PCR, 1 (17%) of whom was in status epilepticus at some point during their clinical course [ 16 , 42 , 50 , 55 , 56 , 59 , 63 ].…”

Section: Resultsmentioning

confidence: 99%

“…After identifying 69 patients who had a seizure in the setting of COVID-19 and had CSF studies available for review [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] , we found that 6/45 (13%) had a positive CSF SARS-CoV-2 PCR (though cycle threshold was not reported for any of them) [3][4][5][6][7][10][11][12][13][14][15][16]18,28,[31][32][33][34][35][36][37]39,41,42,45,[50][51][52][53]55,56,59,60,...…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid findings in patients with seizure in the setting of COVID-19: A review of the literature

Carroll

Melmed

Frontera

et al. 2021

Seizure

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract