Posterior parietal cortex and episodic retrieval: Convergent and divergent effects of attention and memory

Hutchinson, J. Benjamin; Uncapher, Melina R.; Wagner, Anthony D.

doi:10.1101/lm.919109

Cited by 266 publications

(270 citation statements)

References 199 publications

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“…Brain activations around the IPS related to familiarity have also been frequently found in the healthy population . The location of this peak of activation is congruent with previous fMRI findings, showing that dorsal parietal activations during memory tasks tend to be in the lower part of this region, that is, the lateral bank of the IPS Hutchinson et al, 2009). …”

Section: Familiarity and Parietal Cortexsupporting

confidence: 90%

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Genon

Collette

Feyers

et al. 2013

Cortex

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Typical Alzheimer's disease (AD) is characterized by an impaired form of associative memory, recollection, that includes the controlled retrieval of associations. In contrast, familiarity-based memory for individual items may sometimes be preserved in the early stages of the disease. This is the first study that directly examines whole brain regional activity during one core aspect of the recollection function: associative controlled episodic retrieval (CER), contrasted to item familiarity in AD patients. Cerebral activity related to associative CER and item familiarity in AD patients and healthy controls (HC) was measured with functional magnetic resonance imaging during a word-pair recognition task to which the process dissociation procedure was applied. Some patients had null CER estimates (AD-), whereas others did show some CER abilities (AD+), although significantly less than HC. In contrast, familiarity estimates were equivalent in the three groups. In AD+, as in controls, associative CER activated the inferior precuneus/posterior cingulate cortex (PCC). When performing group comparisons, no region was found to be significantly more activated during CER in HC than AD+ and vice versa. However, during associative CER, functional connectivity between this region and the hippocampus, the inferior parietal and dorsolateral prefrontal cortex (DLPFC) was significantly higher in HC than in AD+. In all three groups, item familiarity was related to activation along the intraparietal sulcus (IPS). In conclusion, whereas the preserved automatic detection of an old item (without retrieval of accurate word association) is related to parietal activation centred on the IPS, the inferior precuneus/PCC supports associative CER ability in AD patients, as in HC. However, AD patients have deficient functional connectivity during associative CER, suggesting that the residual recollection function in these patients might be impoverished by the lack of some recollection-related aspects such as autonoetic quality, episodic details and verification.

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Section: Familiarity and Parietal Cortexsupporting

confidence: 90%

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Genon

Collette

Feyers

et al. 2013

Cortex

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“…The PPC is commonly divided into the superior parietal lobe (SPL) which lies dorsal to the intra-parietal sulcus (IPS), and the more ventral inferior parietal lobe (IPL), which comprises the angular gyrus (AG), the supramarginal gyrus (SMG) and the temporo-parietal junction (TPJ) Olson & Berryhill, 2009;Hutchinson et al, 2009). Accurate targeting of each subject's right SMG for TMS was achieved using procedures previously described by this and other laboratories (Sack et al, 2009;McKeefry et al, 2008) using a 3-D ultrasound digitizer CMS30P (Zebris, Tübingen, Germany) in conjunction with the BrainVoyager QX software (version 2.0 Brain Innovation, Netherlands).…”

Section: Selection and Identification Of Areas For Tmsmentioning

confidence: 99%

The contribution of the right supra-marginal gyrus to sequence learning in eye movements

et al. 2013

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We investigated the role of the human right Supra-Marginal Gyrus (SMG) in the generation of learned eye movement sequences. Using MRI-guided transcranial magnetic stimulation (TMS) we disrupted neural activity in the SMG whilst human observers performed saccadic eye movements to multiple presentations of either predictable or random target sequences. For the predictable sequences we observed shorter saccadic latencies from the second presentation of the sequence. However, these anticipatory improvements in performance were significantly reduced when TMS was delivered to the right SMG during the inter-trial retention periods. No deficits were induced when TMS was delivered concurrently with the onset of the target visual stimuli. For the random version of the task, neither delivery of TMS to the SMG during the inter-trial period nor during the presentation of the target visual stimuli produced any deficit in performance that was significantly different from the no-TMS or control conditions. These findings demonstrate that neural activity within the right SMG is causally linked to the ability to perform short latency predictive saccades resulting from sequence learning. We conclude that neural activity in rSMG constitutes an instruction set with spatial and temporal directives that are retained and subsequently released for predictive motor planning and responses.3

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“…The attentional account of PPC retrieval effects, while conceptually attractive at a number of levels, has been challenged by recent meta-analytic (Hutchinson et al 2009) and withinstudy (Sestieri et al 2010(Sestieri et al , 2011 evidence that suggests that the PPC subregions associated with top-down and bottom-up attention are anatomically separable from those associated with episodic retrieval (see also Shannon and Buckner (2004) for evidence of further visuospatial attention/retrieval dissociations). For example, drawing on the published attention and memory literatures, Hutchinson et al (2009) systematically assessed the overlap in PPC between effects of top-down and bottom-up attention and those of item memory strength and recollection.…”

Section: Introductionmentioning

confidence: 99%

“…For example, drawing on the published attention and memory literatures, Hutchinson et al (2009) systematically assessed the overlap in PPC between effects of top-down and bottom-up attention and those of item memory strength and recollection. While the spatial resolution of the implemented meta-analytic approach was inherently limited, Hutchinson's findings suggest that memory strength effects in dorsal PPC may be located lateral to top-down attention effects and that recollection effects in ventral PPC may be located posterior to bottom-up attention effects.…”

Section: Introductionmentioning

confidence: 99%

Functional Heterogeneity in Posterior Parietal Cortex Across Attention and Episodic Memory Retrieval

et al. 2012

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While attention is critical for event memory, debate has arisen regarding the extent to which posterior parietal cortex (PPC) activation during episodic retrieval reflects engagement of PPCmediated mechanisms of attention. Here, we directly examined the relationship between attention and memory, within and across subjects, using functional magnetic resonance imaging attentionmapping and episodic retrieval paradigms. During retrieval, 4 functionally dissociable PPC regions were identified. Specifically, 2 PPC regions positively tracked retrieval outcomes: lateral intraparietal sulcus (latIPS) indexed graded item memory strength, whereas angular gyrus (AnG) tracked recollection. By contrast, 2 other PPC regions demonstrated nonmonotonic relationships with retrieval: superior parietal lobule (SPL) tracked retrieval reaction time, consistent with a graded engagement of top-down attention, whereas temporoparietal junction displayed a complex pattern of belowbaseline retrieval activity, perhaps reflecting disengagement of bottom-up attention. Analyses of retrieval effects in PPC topographic spatial attention maps (IPS0-IPS5; SPL1) revealed that IPS5 and SPL1 exhibited a nonmonotonic relationship with retrieval outcomes resembling that in the SPL region, further suggesting that SPL activation during retrieval reflects top-down attention. While demands on PPC attention mechanisms vary during retrieval attempts, the present functional parcellation of PPC indicates that 2 additional mechanisms (mediated by latIPS and AnG) positively track retrieval outcomes.

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Posterior parietal cortex and episodic retrieval: Convergent and divergent effects of attention and memory

Cited by 266 publications

References 199 publications

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

The contribution of the right supra-marginal gyrus to sequence learning in eye movements

Functional Heterogeneity in Posterior Parietal Cortex Across Attention and Episodic Memory Retrieval

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