Posterior (Outward) Migration of the Lamina Cribrosa and Early Cupping in Monkey Experimental Glaucoma

Yang, Hongli; Williams, Galen; Downs, J. Crawford; Sigal, Ian A.; Roberts, Michael D.; Thompson, Hilary W.; Burgoyne, Claude F.

doi:10.1167/iovs.11-7448

Cited by 153 publications

(155 citation statements)

References 48 publications

(112 reference statements)

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“…[1][2][3][4][5][6][7] Under the biomechanical paradigm for glaucoma pathogenesis, the influence of increased intraocular pressure (IOP) on the LC has been widely elucidated in experimental glaucoma animal models. [7][8][9][10][11][12] Early experimental glaucoma monkey eyes, for example, showed posterior migration of anterior and posterior laminar insertion. 12 Posterior displacement of laminar insertion has been confirmed in autopsied and enucleated human eyes with advanced glaucoma.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9][10][11][12] Early experimental glaucoma monkey eyes, for example, showed posterior migration of anterior and posterior laminar insertion. 12 Posterior displacement of laminar insertion has been confirmed in autopsied and enucleated human eyes with advanced glaucoma. 3 Recently, posterior displacement of anterior laminar insertion has been investigated in in vivo human eyes using swept-source optical coherence tomography (SS-OCT).…”

Section: Introductionmentioning

confidence: 99%

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Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Kim

Jeoung

et al. 2015

Eye

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Purpose To investigate peripheral lamina cribrosa depth (PLCD) and its verticalhorizontal difference in eyes with primary open-angle glaucoma (POAG). Methods Patients with POAG (n = 90 eyes) and age-matched healthy individuals (n = 90 eyes) underwent swept-source optical coherence tomography (SS-OCT) scans centered at the optic discs. The PLCD was defined as the vertical distance between the most peripheral visible end of anterior lamina cribrosa (LC) surface and the reference plane connecting the Bruch's membrane openings. The PLCD in each quadrant region and the vertical-horizontal PLCD difference were compared between the POAG and healthy eyes. The clinical factors associated with increased PLCD were evaluated. Results The PLCD was significantly larger in the POAG eyes than the control eyes at the horizontal (P = 0.034) and vertical (P = 0.001) meridians. The vertical PLCD was significantly larger than the horizontal PLCD, both in the POAG eyes (Po0.001) and in the control eyes (P = 0.003). However, the vertical-horizontal PLCD difference was significantly larger in the POAG eyes (47 ± 60 μm) than in the control eyes (18 ± 54 μm, P = 0.001). Multivariate regression showed a significant association of male gender (P = 0.005), increased baseline IOP (P = 0.043), and decreased MD of VF (P = 0.025) with increased PLCD. Conclusions The peripheral LC was displaced more posteriorly in the POAG eyes compared with the age-matched healthy eyes. In the POAG eyes, the peripheral LC was displaced more posteriorly at the vertical meridian than at the horizontal meridian. The peripheral LC in the vertical meridian might have increased IOP-related strain (deformation) compared with horizontal meridian in glaucomatous eyes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Kim

Jeoung

et al. 2015

Eye

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“…3 Experimental glaucoma monkey models have demonstrated progressive posterior migration of the anterior and posterior LC insertions. 6 The LC is located more posteriorly within the ONH in glaucomatous eyes than in healthy eyes, based on histologic studies using glaucomatous eyes or in vivo studies using enhanced depth imaging optical coherence tomography (EDI OCT). [7][8][9] Therefore, a deep LC may indicate that the ONH has been put under substantial mechanical stress.…”

mentioning

confidence: 99%

Factors Affecting Plastic Lamina Cribrosa Displacement in Glaucoma Patients

Jung

Park

et al. 2014

Investigative Ophthalmology & Visual Science

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PURPOSE.To investigate factors associated with irreversible components of anterior lamina cribrosa (LC) depth in glaucoma patients. METHODS.A total of 141 glaucoma patients and 51 healthy control subjects were enrolled. The optic nerve head (ONH) was imaged using the enhanced depth imaging (EDI) modes of Spectralis optical coherence tomography (OCT). The depth of the LC was measured at the midhorizontal, superior, and inferior midperipheral regions of the ONH of each eye. Analyzed factors associated LC depth included age, axial length, intraocular pressure (IOP), disc size, central corneal thickness, average retinal nerve fiber layer (RNFL) thickness, and mean deviation (MD). RESULTS.In glaucoma patients, the LC was more deeply located compared with the control group at the midhorizontal and superior and inferior midperipheral B-scans (All P < 0.001). Age, initial IOP, and treated IOP was correlated with mean LC depth (All P < 0.001), and those correlations remained after adjusting for MD and RNFL thickness (All P < 0.001). In multivariate analysis, younger age, high untreated IOP, and thinner RNFL thickness was significantly associated with a deeper LC (P ¼ 0.015, <0.001, and 0.042). There was an interaction between age and MD as predictors for LC depth (P ¼ 0.007).CONCLUSIONS. The anterior LC surface is more deeply located in glaucoma patients compared with healthy controls. In glaucoma patients, age, initial IOP, and RNFL thickness were influential factors related to LC depth. These factors should be considered in clinical application of plastic LC displacement in glaucoma patients.

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“…[8][9][10][11][12][13][14][15] Our group and others have previously examined the fibrotic phenotype associated with glaucoma in the LC and TM regions, including increased expression of collagen type 1. 9,15,16 In glaucoma, the LC undergoes thickening 17 and posterior migration 18 in the early stages of the disease process, and later undergoes shearing and collapse of the LC plates finally leading to a thin fibrotic connective tissue structure/scar. 19 Similar to the LC, the TM of patients with POAG is characterized by the buildup of ECM material 20 and this accumulation eventually results in increased outflow resistance with subsequent elevated IOP.…”

mentioning

confidence: 99%

Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix Production in Trabecular Meshwork and Lamina Cribrosa Cells

Wallace

Clark

Lipson

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Posterior (Outward) Migration of the Lamina Cribrosa and Early Cupping in Monkey Experimental Glaucoma

Abstract: Posterior migration of the lamina cribrosa is a component of early cupping in monkey EEG.

Cited by 153 publications

References 48 publications

Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Factors Affecting Plastic Lamina Cribrosa Displacement in Glaucoma Patients

Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix Production in Trabecular Meshwork and Lamina Cribrosa Cells

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