Posterior Hippocampal Volumes Are Associated with Remission Rates in Patients with Major Depressive Disorder

MacQueen, Glenda; Yücel, Kaan; Taylor, Valerie H.; MacDonald, Kathryn

doi:10.1016/j.biopsych.2008.06.027

Cited by 238 publications

(154 citation statements)

References 21 publications

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“…Moreover, patients with geriatric depression and small right hippocampal volumes were less likely to achieve remission compared with those with larger hippocampal volumes (Hsieh et al, 2002), and women who responded to 8 weeks of fluoxetine had larger right HC volumes than non-responders (Vakili et al, 2000). Smaller HC volumes also predicted low rates of remission in patients with no past treatment history, suggesting that the association between HC volumes and short-term clinical response was not simply a function of past treatment responsiveness (MacQueen et al, 2008).…”

Section: Structural Brain Changes Due To Stress T Frodl Et Almentioning

confidence: 95%

Childhood Stress, Serotonin Transporter Gene and Brain Structures in Major Depression

Frodl

Reinhold

Koutsouleris

et al. 2010

Neuropsychopharmacol

184

106

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The underlying neurobiology of major depression (MD) is likely to represent an interaction between genetic susceptibility and environmental factors such as stress. We investigated, in a multimodal high-resolution magnetic resonance imaging (MRI) genetic study, whether reduced hippocampal volumes and other brain alterations are associated with the tri-allelic polymorphism of the serotonin transporter and childhood stress in patients with MD and healthy subjects. Patients with MD and healthy participants were investigated using high-resolution MRI and genotyping for serotonin transporter polymorphism in the promoter region of the serotonin transporter gene (SLC6A4, 5-HTTLPR). Region of interest analysis of the hippocampus, whole-brain voxel-based morphometry (VBM), and assessment of childhood stress were carried out. Patients carrying the risk S-allele developed smaller hippocampal volumes when they had a history of emotional neglect compared with patients who only had one risk factor (environmental or genetic). In patients, childhood stress also predicted further hippocampal white matter alterations independently from the genotype. Moreover, the left prefrontal cortex was smaller in patients, whereby childhood stress resulted in larger prefrontal volumes in those subjects carrying the non-risk L-allele, suggesting preventive effects. The findings indicate that subjects with both environmental and genetic risk factors are susceptible to stress-related hippocampal changes. Structural brain changes due to stress represent part of the mechanism by which the illness risk and outcome might be genetically mediated.

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Section: Structural Brain Changes Due To Stress T Frodl Et Almentioning

confidence: 95%

Childhood Stress, Serotonin Transporter Gene and Brain Structures in Major Depression

Frodl

Reinhold

Koutsouleris

et al. 2010

Neuropsychopharmacol

184

106

View full text Add to dashboard Cite

show abstract

“…Antidepressant treatment reduces CBF and metabolism in the amygadala (Drevets, 2000b;Drevets et al, 1999), attenuating hyperresponsiveness to stress (Rosenkranz et al, 2010). Similarly, larger hippocampal volume (Frodl et al, 2008;Kronmuller et al, 2008;MacQueen et al, 2008) and gray matter density in the ACC (Costafreda et al, 2009) were positively correlated with antidepressant response.…”

Section: Neurostructural and Neurofunctional Studiesmentioning

confidence: 99%

Biological Alterations in Depression

Benton¹,

Wiltshire²

2011

Psychiatric Disorders - Trends and Developments

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“…Structural MRI studies have reported that small hippocampal volumes are associated with poor short-and long-term clinical outcomes in patients with major depressive disorder. [6][7][8][9] Reports of small hippocampal volumes being associated with poor clinical outcome are, so far, mostly confined to studies of patients with major depression, despite the fact that the hippocampus is known to be small in a variety of neuropsychiatric conditions. 10 Functional MRI studies and other imaging modalities have shown that activity in the anterior cingulate cortex is predictive of clinical response to antidepressant medication and to cognitive behaviour therapy for depression and anxiety.…”

mentioning

confidence: 99%