Posterior fossa tumors in infants and neonates

Spennato, Pietro; Nicosia, Giancarlo; Quaglietta, Lucia; Donofrio, Vittoria; Mirone, Giuseppe; Martino, Giuliana Di; Guadagno, Elia; De, Marialaura Del Basso; Cascone, Daniele; Cinalli, Giuseppe

doi:10.1007/s00381-015-2783-6

Cited by 29 publications

(27 citation statements)

References 48 publications

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“…All iEPNs were posterior fossa group A (7). Group A EPN patients in general are younger, have tumors more frequently located in the cerebellopontine angle (67% vs 5%) and they experience a higher recurrence rate (56% vs 25%), metastasis at recurrence, and death (35% vs 5%) compared to group B patients (7,8). In particular, iEPNs appear to have a worse prognosis than EPNs in older children, with 26% survival vs 63% in older children (2-3 years) over the same follow-up time period (9).…”

Section: Introductionmentioning

confidence: 99%

SOX10 Distinguishes Pilocytic and Pilomyxoid Astrocytomas From Ependymomas but Shows No Differences in Expression Level in Ependymomas From Infants Versus Older Children or Among Molecular Subgroups

Kleinschmidt‐DeMasters

Donson

Richmond

et al. 2016

J Neuropathol Exp Neurol

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SOX10 is important in nonneoplastic oligodendroglial development, but mRNA transcripts and protein expression are identified in a wider variety of CNS glial neoplasms than oligodendrogliomas. We previously demonstrated high levels of SOX10 mRNA and protein in pilocytic astrocytomas (PAs) but not ependymomas (EPNs). We now extend these studies to investigate subsets of these 2 tumors that affect infants, pilomyxoid astrocytomas (PMAs) and infant (<1 year) ependymomas (iEPNs). By gene expression microarray analysis, we found that iEPNs and all EPNs in older children showed very low SOX10 expression levels, on average 7.1-fold below normal control tissues. EPN groups showed no significant difference in SOX10 expression between iEPN and EPN. PAs/PMAs had 24.1/29.4-fold higher transcript levels, respectively, than those in normal tissues. Using immunohistochemical analysis of adult, pediatric, and infantile EPNs and of PAs/PMAs, we found that EPNs from multiple anatomical locations and both age groups (n = 228) never showed 3+ diffuse nuclear immunostaining for SOX10; the majority were scored at 0 or 1+. Conversely, almost all pediatric and adult PAs and PMAs (n = 47) were scored as 3+. These results suggest that in select settings, SOX10 immunohistochemistry can supplement the diagnosis of PMA and PA and aid in distinguishing them from EPNs.

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Section: Introductionmentioning

confidence: 99%

SOX10 Distinguishes Pilocytic and Pilomyxoid Astrocytomas From Ependymomas but Shows No Differences in Expression Level in Ependymomas From Infants Versus Older Children or Among Molecular Subgroups

Kleinschmidt‐DeMasters

Donson

Richmond

et al. 2016

J Neuropathol Exp Neurol

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“…spatial location of the lesions differs from that in adults, with pediatric tumors commonly located infratentorially, including the brain stem, which renders surgical resection more difficult. 2 Location in eloquent areas might delay an operation when the risk of postoperative deficit is weighed against potential longer overall survival, or it may even hamper an operation. Thus, presurgical grading into low-or high-grade tumor, respectively, is of clinical importance for therapeutic and surgical decisions.…”

mentioning

confidence: 99%

Arterial Spin-Labeling in Children with Brain Tumor: A Meta-Analysis

Delgado

Luca

Hanagandi

et al. 2018

AJNR Am J Neuroradiol

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“…General preoperative preparation was consistent with local protocol over the time period of data collection, involving surgical site preparation with alcoholic betadine and administration of antibiotics 30 min prior to skin incision. The standard approach for all cases was midline suboccipital craniotomy, Y-shaped dural opening [1], and watertight dural closure with DuraGen® (Integra) and Tisseel fibrin sealant (Baxter). Postoperative infection was defined as the occurrence of wound infection (superficial or deep), meningitis, or ventriculitis during the postoperative period.…”

Section: Methodsmentioning

confidence: 99%

“…With the exclusion of brainstem tumours, the current standard of care for patients with malignant posterior fossa tumours remains maximal safe surgical resection followed by chemoand/or radiotherapy [1]. Postoperative surgical site infection (SSI) can however result in a prolonged hospitalisation and potentially a delay in commencement of postop adjuvant therapy.…”

Section: Introductionmentioning

confidence: 99%

Surgical site infection in paediatric posterior fossa surgery: does pathology matter?

et al. 2021

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Objectives The aim of this study was to explore the rates and potential risks of surgical site infection (SSI) after posterior fossa surgery for tumour resection in children. Methods We retrospectively reviewed our local paediatric (age < 16 years) database for all cases of posterior fossa (PF) brain tumour surgery between November 2008 and November 2019. We collected patient demographics, tumour histology/location, and the event of postoperative surgical site infection. Results Overall, 22.1% (n=15) developed SSI out of sixty-eight children undergoing PF surgery for resection of brain tumours; 73.3% of them had a confirmed diagnosis of medulloblastoma. There was no statistically significant difference in the age (5.1 ± 0.60 vs. 6.2 ± 0.97 years; p=0.47) and duration of operation (262 vs. 253 min; p = 0.7655) between the medulloblastoma group and other tumours. Although the rate of postoperative hydrocephalus was higher in the medulloblastoma group (12.9% vs. 0%), this was not associated with increased SSI. Rates of CSF leak between the 2 groups were not different. Conclusion Medulloblastoma as a pathological entity seems to carry higher risk of postoperative surgical site infection compared to other types of paediatric posterior fossa tumours. Further larger studies are required to look into this causal relationship and other risk factors that might be involved.

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Posterior fossa tumors in infants and neonates

Cited by 29 publications

References 48 publications

SOX10 Distinguishes Pilocytic and Pilomyxoid Astrocytomas From Ependymomas but Shows No Differences in Expression Level in Ependymomas From Infants Versus Older Children or Among Molecular Subgroups

SOX10 Distinguishes Pilocytic and Pilomyxoid Astrocytomas From Ependymomas but Shows No Differences in Expression Level in Ependymomas From Infants Versus Older Children or Among Molecular Subgroups

Arterial Spin-Labeling in Children with Brain Tumor: A Meta-Analysis

Surgical site infection in paediatric posterior fossa surgery: does pathology matter?

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