Cone-beam computed tomography is a three-dimensional imaging method that offers the possibility to view an individual tooth or teeth at any view and overcomes many of the limitations of conventional radiographs. A review of the literature has been conducted in order to summarize the main criteria for the use of cone-beam computed tomography in the field of endodontics. Three-dimensional imaging is proven to ensure more accurate diagnosis and therefore improved management of complex endodontic cases and so to rapidly influence the assessment of complex root canal anatomy, periapical periodontitis, root resorption, dental traumas and root fractures. Cone-beam computed tomography can be a powerful tool in endodontic treatment planning, assessing the outcome of the root canal treatment and follow-ups. That is the reason for the rapid increase of the use of cone beam computed tomography in the field of endodontics worldwide.