Posterior cingulate gyrus metabolic changes in chronic schizophrenia with generalized cognitive deficits

Shimizu, Eiji; Hashimoto, Kenji; Ochi, Shigehiro; Fukami, Goro; Fujisaki, Mihisa; Koike, Kaori; Okamura, Naoe; Ohgake, Shintaro; Koizumi, Hiroki; Matsuzawa, Daisuke; Zhang, Lin; Watanabe, Hiroyuki; Nakazato, Michiko; Shinoda, Naoyuki; Komatsu, Naoya; Morita, Fuminori; Iyo, Masaomi

doi:10.1016/j.jpsychires.2005.04.015

Cited by 33 publications

(20 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The temporoparietal and frontocerebellar networks significantly differentiated between SSD patients and HC suggesting significant decreases of GMV in the frontal gyrus, PCC, supramarginal gyrus, temporal gyrus, lingual gyrus, M1, precuneus, and cerebellar structures. GMV reduction in these regions, which are involved in important sensorimotor and cognitive functions, is consistent with previous MRI studies on SSD patients (Iwashiro et al, 2012;Kikinis et al, 2010;Koo et al, 2008;Shimizu et al, 2007;Tang et al, 2012;Torii et al, 2012;Zhou et al, 2005). Furthermore, the present study is in line with the recent mCCA + jICA study by Lottman and colleagues (Lottman et al, 2018), once again highlighting the relationship between GMV alterations and aberrant INA in SSD.…”

Section: Group Differencessupporting

confidence: 93%

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Hirjak

Rashidi

Fritze

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

Neurological soft signs (NSS) comprise a broad range of subtle neurological deficits and are considered to represent external markers of sensorimotor dysfunction frequently found in mental disorders of presumed neurodevelopmental origin. Although NSS frequently occur in schizophrenia spectrum disorders (SSD), specific patterns of co‐altered brain structure and function underlying NSS in SSD have not been investigated so far. It is unclear whether gray matter volume (GMV) alterations or aberrant brain activity or a combination of both, are associated with NSS in SSD. Here, 37 right‐handed SSD patients and 37 matched healthy controls underwent motor assessment and magnetic resonance imaging (MRI) at 3 T. NSS were examined on the Heidelberg NSS scale. We used a multivariate data fusion technique for multimodal MRI data—multiset canonical correlation and joint independent component analysis (mCCA + jICA)—to investigate co‐altered patterns of GMV and intrinsic neural fluctuations (INF) in SSD patients exhibiting NSS. The mCCA + jICA model indicated two joint group‐discriminating components (temporoparietal/cortical sensorimotor and frontocerebellar/frontoparietal networks) and one modality‐specific group‐discriminating component (p < .05, FDR corrected). NSS motor score was associated with joint frontocerebellar/frontoparietal networks in SSD patients. This study highlights complex neural pathomechanisms underlying NSS in SSD suggesting aberrant structure and function, predominantly in cortical and cerebellar systems that critically subserve sensorimotor dynamics and psychomotor organization.

show abstract

Section: Group Differencessupporting

confidence: 93%

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Hirjak

Rashidi

Fritze

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Also, increased NMDA receptor binding has been reported in the PC of schizophrenia patients, perhaps as the result of NMDA receptor hypofunction (Newell, Zavitsanou, and Huang, 2005). Finally, decreased NAA/Cr ratios in the PC have been reported in patients with chronic schizophrenia that exhibit cognitive deficits (Shimizu et al, 2007). These findings, taken together with reports that NMDA receptor antagonists such as phencyclidine (PCP) and ketamine can cause schizophrenia-like psychosis and cognitive dysfunction in healthy humans (Andine et al, 1999,Javitt and Zukin, 1991,Malhotra et al, 1996 are consistent with the more general hypothesis that NMDA receptor dysfunction could be the basis for neurodegenerative changes in the cingulate gyrus of patients with schizophrenia.…”

Section: Discussionmentioning

confidence: 98%

Abnormalities of cingulate gyrus neuroanatomy in schizophrenia

Wang

Hosakere

Trein

et al. 2007

Schizophrenia Research

View full text Add to dashboard Cite

Objective and Methods: Abnormalities of the neuroanatomy of the gray matter of the cingulate gyrus, especially its anterior segment, have been suggested to be an important characteristic of schizophrenia. In this study, T1-weighted magnetic resonance scans were collected in 53 individuals with schizophrenia and 68 comparison subjects matched for age, gender, race and parental socioeconomic status. We applied Labeled Cortical Mantle Distance Mapping to assess the volume, surface and thickness of the cortical mantle within the anterior (AC) and posterior (PC) segments of the cingulate gyrus, excluding the paracingulate gyrus, and related these anatomical measures to measures of psychopathology and illness duration. Results:After covarying for total cerebral volume, individuals with schizophrenia showed smaller AC gray matter volume (p=0.024), thickness (trend, p=0.081), but not surface area (p=0.16), than comparison subjects. Similar group differences were found for PC gray matter volume (p=0.0005) and thickness (trend, p=0.055), but not surface area (p=0.15). Across both groups, there was a significant L>R asymmetry in thickness of the AC, and a significant L>R asymmetry in the surface area of the PC. However, there were no significant group-by-hemisphere interactions. In the individuals with schizophrenia, thinning of the AC, but not the PC, was correlated with a longer duration of illness and a greater severity of psychotic symptoms.Conclusions: Individuals with schizophrenia showed smaller gray matter volumes across the entire cingulate gyrus, mostly due to a reduction in cortical mantle thickness. However, structural measures of the AC were more closely related to clinical features of the illness.

show abstract

“…), in medicated CSP (Shimizu et al . ), in medicated ROP (Yasukawa et al . ), in minimally treated schizophrenia subjects with no changes following anti‐psychotic treatment (Bustillo et al .…”

Section: H‐mrs Findings In Schizophreniamentioning

confidence: 99%

Metabolic alterations associated with schizophrenia: a critical evaluation of proton magnetic resonance spectroscopy studies

Schwerk

Alves

Pouwels

et al. 2013

Journal of Neurochemistry

View full text Add to dashboard Cite

By reviewing the existing 1 H-magnetic resonance spectroscopy literature in schizophrenia, the relationship of different sample characteristics and applied methodologies with metabolite alterations is explored. Furthermore, we emphasize common pitfalls and discrepancies in the methodological framework of the reviewed studies that introduce unwanted variation in findings and complicate the comparison of studies. A total of 92 studies were reviewed. Articles were retrieved by searching the Pubmed database. Care was taken to note down reliability and validity measures of each included study. Despite many methodological differences and shortcomings, progressive NAA reductions could be seen in several brain regions implicated in the pathogenesis of schizophrenia. In terms of treatment effects, cross-sectional evidence implicates a normalizing role for atypical antipsychotic medication; however, longitudinal studies remain inconclusive on this issue. Choline, creatine, and myo-inositol levels remain largely unchanged and a time-dependent role of glutamate finds confirmation in several spectroscopy studies. Other findings are less consistent and need further replication. Most studies lack power and methodological precision. Future studies should aim for standardization and for more distinguished study populations to gain more valid and reliable findings.

show abstract

Posterior cingulate gyrus metabolic changes in chronic schizophrenia with generalized cognitive deficits

Cited by 33 publications

References 58 publications

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Abnormalities of cingulate gyrus neuroanatomy in schizophrenia

Metabolic alterations associated with schizophrenia: a critical evaluation of proton magnetic resonance spectroscopy studies

Contact Info

Product

Resources

About