Posterior capsule opacification: What's in the bag?

Abstract

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Comparison of Clinical Outcomes, Visual Quality and Visual Function of Two Presbyopia-Correcting Intraocular Lenses Made from the Same Material, but with Different Design and Optics

“…In contrast, almost two-thirds of the AT LISA tri eyes developed PCO, and two-thirds of these eyes had a perceptible decrease in vision that required surgical management. Because all surgeries were performed by the same experienced surgeon using the same surgical protocol with the utmost caution, we believe that the differences in frequency and severity of PCO are likely explained by differences in IOL design [16,46]. We acknowledge that our reported 1-year rates for PCO and Nd:YAG capsulotomy are higher than those reported in other studies [29,[47][48][49].…”

Immune responses to injury and their links to eye disease

“…While generally a highly successful procedure, a large number of post-cataract surgery patients develop a fibrotic vision-impairing condition called Posterior Capsule Opacification (PCO) along the fiber cell-denuded region of posterior lens capsule [173]. At the cellular and molecular level, PCO is linked to the appearance of Collagen I-producing, αSMA+ myofibroblasts, of which one well-characterized source is the epithelial-mesenchymal transition (EMT) of lens epithelial cells [174][175][176][177][178][179][180][181][182][183][184][185][186][187][188].…”

“…In contrast, there is a significant literature showing post-cataract surgery complications in patients with uveitis, particularly if inflammation is not controlled prior to surgery. The complications of cataract surgery in patients with uveitis include PCO, glaucoma, macular edema, and retinal detachments [173,[203][204][205], evidence that many regions of the eye are impacted by ocular inflammation after cataract surgery. Together with the discovery that immune surveillance of the lens is induced when the cornea is wounded [163] and the surveillance of the cornea and retina by immune cells in induced in response to lens degeneration [164], these findings demonstrate that immune responses across the eye are highly interactive.…”

PP‐1β and PP‐2Aα modulate cAMP response element‐binding protein (CREB) functions in aging control and stress response through de‐regulation of αB‐crystallin gene and p300‐p53 signaling axis

“…Cataract is an aging disease that in most cases is derived from aging process or environmental stress induction (Cogan, 1973 ) besides genetic mutations (Shiels & Hejtmancik, 2019 ). Over two centuries of studies have revealed that many different factors can induce cataractogenesis (Bloemendal, 1991 ; Lim et al, 2020 ; Schey et al, 2020 ; Shu & Lovicu, 2017 ; Wormstone et al, 2020 ). Mechanistically, we have previously demonstrated that stress‐induced apoptosis is a common cellular basis for non‐congenital cataractogenesis (Li et al, 1995 ; Li & Spector, 1996 ).…”