Posterior brain in fetuses with Dandy–Walker malformation with complete agenesis of the cerebellar vermis at 11–13 weeks: a pilot study

Lachmann, Robert; Sinkovskaya, Elena; Abuhamad, Alfred

doi:10.1002/pd.3899

Cited by 48 publications

(98 citation statements)

References 6 publications

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“…These suspicious first‐trimester findings were subsequently diagnosed as clear malformations of the posterior fossa. It appears that such findings may not be limited only to the most severe forms of Dandy‐Walker malformation with complete agenesis of the vermis, as suggested by Lachmann et al 7 In our limited experience, abnormally large posterior fossa or intracranial translucency and brain stem‐to‐occipital bone diameters were detected in cases with less severe manifestations, such as in a fetus with a Dandy‐Walker malformation with only partial vermian agenesis as well as in a fetus with inferior vermian hypoplasia. Therefore, we suggest that evaluation of the posterior fossa by visual inspection for obvious alterations in the early fourth ventricle‐cisterna magna complex and, when needed, by measuring the intracranial translucency, brain stem‐to‐occipital bone diameter, or both may be used as markers for posterior fossa malformations.…”

Section: Discussionmentioning

confidence: 73%

“…In addition, the brain stem‐to‐occipital bone diameter (the distance between the posterior border of the brain stem and the occipital bone) was also reported to be smaller in cases of open spina bifida 6 . In a recent study, Lachmann et al 7 retrospectively examined the posterior fossa from stored nuchal translucency images of 4 fetuses with diagnoses of a Dandy‐Walker malformation and complete agenesis of the vermis during the second trimester. They evaluated the fourth ventricle‐cisterna magna complex by measuring the brain stem‐to‐occipital bone diameter on the median plane as they had previously described 6 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

First‐Trimester Sonographic Findings Associated With a Dandy‐Walker Malformation and Inferior Vermian Hypoplasia

Bornstein¹,

Rodríguez²,

Pavón³

et al. 2013

J of Ultrasound Medicine

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We report 2 cases in which first-trimester measurements of the intracranial translucency and the brain stem-to-occipital bone diameter were markedly enlarged. This finding was thought to represent an abnormal fourth ventricle-cisterna magna complex. Subsequently, the diagnoses of a Dandy-Walker malformation with partial vermian agenesis in 1 case and inferior vermian hypoplasia in the other were established and confirmed by either postmortem autopsy or postnatal magnetic resonance imaging. These cases suggest that evaluation of the fourth ventricle-cisterna magna complex, by measuring the intracranial translucency or brain stem-to-occipital bone diameter may identify some cases with structural malformations of the cerebellum as early as the first trimester.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

First‐Trimester Sonographic Findings Associated With a Dandy‐Walker Malformation and Inferior Vermian Hypoplasia

Bornstein¹,

Rodríguez²,

Pavón³

et al. 2013

J of Ultrasound Medicine

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“…Some articles have been published for Dandy Walker syndromes as a reason of enlarged IT [24][25][26] . Iuculano et al reported a case of enlarged IT with Blake`s pouch cyst [27] .…”

Section: Discussionmentioning

confidence: 99%

Intracranial translucency as a sonographic marker of open spina bifida at first trimester

Kara¹

2014

IJDI

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Spina bifida is the one of the most common severe congenital abnormality of the central nervous system. Scalloping of the frontal bones called "the lemon sign" and caudal displacement of the cerebellum called "the banana sign" are known as cranial signs of open spina bifida on ultrasonography at the second trimester. Although these signs are useful methods in diagnosing of open spina bifida in the second trimester, detection rates of open spina bifida by using these signs in the first trimester are low. Intracranial translucency is a new sonographic landmark that may be valuable for the early detection of open spina bifida in the first trimester.In this study using of intracranial translucency as a sonographic marker of open spina bifida at first trimester is discussed with the light of recent literature.

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“…In future studies it could also be interesting to compare data from fetuses with increased CSF as observed in Trisomy 18, 13 or others [16] or in the group at high risk for a Dandy-Walker malformation [17] or Blake's pouch cyst.…”

Section: Discussionmentioning

confidence: 99%

Fluid Area Measurements in the Posterior Fossa at 11-13 Weeks in Normal Fetuses and Fetuses with Open Spina Bifida

Karl

Chaoui²

2015

Fetal Diagn Ther

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Objectives: To measure the area of the intracranial translucency (IT) (syn: 4th ventricle) and the future cisterna magna (CM) in normal fetuses and to compare with fetuses with open spina bifida. Patients: In the midsagittal plane of the face of 220 fetuses between 11 and 13 weeks' gestation, the areas of the IT and CM were measured and the sum, defined as the posterior fossa fluid (PFF) area was calculated. Reference ranges were constructed in relation to the crown-rump length. The study group consisted of 21 fetuses with open spina bifida and showed in all cases a single pocket of fluid in the posterior fossa. Fetuses with no fluid in the fossa were excluded. This PFF-area was measured and compared with the reference range of the IT-area and the PFF-area of normal fetuses and Z-scores were calculated. Results: In normal fetuses, a significant increase of the IT-, the CM- and the PFF-area was found as a sign of the expanding posterior fossa. The mean PFF-area increased from 8.55 to 29.72 mm² in the observation period. Fetuses with open spina bifida had reduced fluid in the posterior fossa with values ranging between 2.39 and 5.08 mm² and significantly lower Z-scores. Conclusions: Fetuses with open spina bifida have an abnormally small posterior fossa at 11-13 weeks' and in cases where the cerebrospinal fluid is still present, the fluid area in the midsagittal plane is reduced when compared to normal fetuses. Area fluid assessment can be an additional useful measurement in suspicious cases for open spina bifida in early gestation.

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Posterior brain in fetuses with Dandy–Walker malformation with complete agenesis of the cerebellar vermis at 11–13 weeks: a pilot study

Abstract: At 11-13 weeks, fetuses with DWM have measurable abnormalities in the posterior brain. An abnormal appearance of the fourth ventricle-cisterna magna complex was present in all four cases of DWM.

Cited by 48 publications

References 6 publications

First‐Trimester Sonographic Findings Associated With a Dandy‐Walker Malformation and Inferior Vermian Hypoplasia

First‐Trimester Sonographic Findings Associated With a Dandy‐Walker Malformation and Inferior Vermian Hypoplasia

Intracranial translucency as a sonographic marker of open spina bifida at first trimester

Fluid Area Measurements in the Posterior Fossa at 11-13 Weeks in Normal Fetuses and Fetuses with Open Spina Bifida

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