Poster #T81 FREQUENCY AND CHARACTERISTICS OF THE ATTENUATED PSYCHOSIS SYNDROME AND DELINEATION TO OTHER RISK PROFILES IN A SAMPLE OF HELP-SEEKING INDIVIDUALS

Clinical Validity ofDSM-5Attenuated Psychosis Syndrome

“…The systematic review of antecedent validators identified only a few records. The prevalence of DSM-5-APS is 0.3% in the general population 36 , 3.5% in college students 40 and highly variable in clinical samples 14,41,42 . The latter point reflects the significant sampling biases that affect the CHR-P/APSS paradigm [69][70][71][72][73] .…”

“…The severity of attenuated psychotic (positive, negative, disorganised and general) symptoms was significantly higher in APSS than non-APSS help-seeking individuals 41,42 ; attenuated psychotic symptoms were also associated with obsessive-compulsive traits, interpersonal sensitivity and depression 40 . The most frequent unusual thought contents were being perplexed by reality and having overvalued beliefs 54 .…”

“…The prevalence of the APSS is 1.3% 39 in the general population and 3.5% in college students 40 . The prevalence of APSS in clinical samples was highly variable ranging from 3.1% 35 to 80% 41 ; the effect of age on the prevalence of DSM-5-APS/APSS in helpseeking samples was inconsistent 38,41,42 .…”

“…Personality disorder traits were also frequent (57.1%) 17 , in particular schizotypal personality disorders (rates varied between 17.0% 38 and 67.8% 18 ) and borderline personality traits (42.9% 17 ). Lifetime suicidality was more frequent in DSM-5-APS/APSS than non-DSM-5-APS/APSS help-seeking individuals 41,42 : about 26.3% 48 -38.9% 17 of the DSM-5-APS/APSS population suffered at least one lifetime suicide attempt and suicidal ideation reached 77.8% 17 . The APSS designation was also associated with an increased risk of violence 49 .…”

“…Despite criterion E, about half (49%) of DSM-5-APS/APSS individuals presented with comorbid depressive disorders, 22% with bipolar disorder, 38% with anxiety disorders, 9% with generalised anxiety disorder, 13% with obsessive-compulsive disorder, 20% with substance use disorders, 13% with cannabis abuse, 7% with alcohol abuse and 22% with social phobia (meta-analytical results are reported in eTable 7-8). Other comorbid disorders that were not meta-analysed because there were less than 3 studies included attention deficit hyperactivity disorder 46,47 , oppositional defiant disorders 17 , conduct disorders 17,38 and posttraumatic stress disorder (eTable 6b) 42 . Personality disorder traits were also frequent (57.1%) 17 , in particular schizotypal personality disorders (rates varied between 17.0% 38 and 67.8% 18 ) and borderline personality traits (42.9% 17 ).…”