Poster session 3

The Role of the Popeye Domain Containing Gene Family in Organ Homeostasis

“…POPDC1 is found both at the nuclear envelope and in some cell types also in the nucleosplasm. The nuclear localization has been reported in various cell lines including cardiac myocytes, myoblasts and epithelial breast cancer cells [2,9,36]. Furthermore, similar nuclear expression patterns have also been observed in the case of POPDC2 and POPDC3 [36,59,60].…”

“…The nuclear localization has been reported in various cell lines including cardiac myocytes, myoblasts and epithelial breast cancer cells [2,9,36]. Furthermore, similar nuclear expression patterns have also been observed in the case of POPDC2 and POPDC3 [36,59,60]. However, the functional implications of this nuclear localization and the mechanisms by which POPDC proteins are transported into the nuclear envelope and the nucleus are currently unknown.…”

“…The molecular basis for the impaired regenerative response is poorly understood. However, in activated satellite cells, POPDC1 is located in the nucleoplasm, while myotube formation triggers a loss of nuclear localization [36]. It will be interesting to find out whether nuclear function of POPDC proteins involves transcriptional control, given that the bacterial CAP and CRP proteins are the closest related proteins.…”