Poster #31 REDUCED CONNECTIVITY IN THE DEFAULT MODE NETWORK OF SCHIZOPHRENIA PATIENTS WITH POOR INSIGHT

Liemburg, E.; Meer, Lisette van der; Swart, Marte; Ćurčić, Branislava; Bruggeman, Richard; Knegtering, Henderikus; Alemán, André

doi:10.1016/s0920-9964(12)70603-5

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“…The precuneus and medial frontal gyrus are both major nodes of the main functional and structural networks of the human brain, with a relevant role within the default mode network (DMN; Utevsky et al, 2014 ). The DMN has been found to be involved in inwardly focused mental processes such as self-referential processing, personal introspection, autobiographical memory, and future thinking, all of which contribute to a coherent sense of self (Bluhm et al, 2009 ; Liemburg et al, 2012 ; Sripada et al, 2012 ; Lanius et al, 2015 ; Pankow et al, 2015 ). However, there are no reported DMN abnormalities in hypochondriasis.…”

Section: Discussionmentioning

confidence: 99%

Gray Matter Volume and Functional Connectivity in Hypochondriasis: A Magnetic Resonance Imaging and Support Vector Machine Analysis

Shen

Zhao

et al. 2020

Front. Hum. Neurosci.

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Objective: Patients with hypochondriasis hold unexplainable beliefs and a fear of having a lethal disease, with poor compliances and treatment response to psychotropic drugs. Although several studies have demonstrated that patients with hypochondriasis demonstrate abnormalities in brain structure and function, gray matter volume (GMV) and functional connectivity (FC) in hypochondriasis still remain unclear.Methods: The present study collected T1-weighted and resting-state functional magnetic resonance images from 21 hypochondriasis patients and 22 well-matched healthy controls (HCs). We first analyzed the difference in the GMV between the two groups. We then used the regions showing a difference in GMV between two groups as seeds to perform functional connectivity (FC) analysis. Finally, a support vector machine (SVM) was applied to the imaging data to distinguish hypochondriasis patients from HCs.Results: Compared with the HCs, the hypochondriasis group showed decreased GMV in the left precuneus, and increased GMV in the left medial frontal gyrus. FC analyses revealed decreased FC between the left medial frontal gyrus and cuneus, and between the left precuneus and cuneus. A combination of both GMV and FC in the left precuneus, medial frontal gyrus, and cuneus was able to discriminate the hypochondriasis patients from HCs with a sensitivity of 0.98, specificity of 0.93, and accuracy of 0.95.Conclusion: Our study suggests that smaller left precuneus volumes and decreased FC between the left precuneus and cuneus seem to play an important role of hypochondriasis. Future studies are needed to confirm whether this finding is generalizable to patients with hypochondriasis.

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