Poster 1026: Randomized clinical trial to evaluate oral dializable leukocyte extracts as immunemodulator treatment in atopic dermatitis

Dialysable leukocyte extracts (DLE) are complexes consisting of a large number of low-molecular-weight substances. These extracts have immunomodulatory properties, which are mainly attributed to small peptides commonly referred to as 'transfer factor'. This review focuses on the characteristics of DLE with transfer factor activity, together with the methods for their preparation and purification. The opportunities for applying the extracts for immunotherapy purposes against various diseases in humans and domestic animals are also discussed. Their ease of preparation and relatively low cost combined with the rapid positive effect they produce will make DLE subject to application in medicine in the future, including their use against new nosological entities.

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“…Similar results were obtained by Garc ıa et al [68] when testing DLE as an immunomodulator treatment in atopic dermatitis.…”

Section: Fungal Parasitic and Allergic Diseasessupporting

confidence: 88%

Dialysable leukocyte extracts in immunotherapy

Arnaudov

Kostova

2015

Biotechnology & Biotechnological Equipment

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“…Transfer factor may be a beneficial adjuvant in the treatment of allergic rhinitis [71] and atopic dermatitis [72].…”

Section: Parasitoses and Allergiesmentioning

confidence: 99%

Immunotherapy with Dialyzable Leukocyte Extracts Containing Transfer Factor

Arnaudov¹

2017

Immunotherapy - Myths, Reality, Ideas, Future

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Dialyzable leukocyte extracts (DLE) are complexes consisting of a large number of low molecular weight substances. These extracts possess immunomodulatory properties, which are mainly attributed to small peptides with molecular weight of 3.5-6.0 kDa called "transfer factor." This chapter reviews the nature and immunological characteristics of DLE containing transfer factor (TF), their mechanism of action and the possible uses as immunomodulators in human and veterinary medicine. A main advantage of TF-preparations as immunotherapeutic agents is that they induce a rapid immune response against the pathogen (within 24 h) and thereby reduce the time for the patient immune response by 9-13 days. The low level of difficulty of the process of obtaining protocols determines their relatively low cost and the possibility to combine them with other therapeutic agents during treatment makes them subject to medical applications in the future, including against some new diseases.

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Poster 1026: Randomized clinical trial to evaluate oral dializable leukocyte extracts as immunemodulator treatment in atopic dermatitis

Cited by 2 publications

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Dialysable leukocyte extracts in immunotherapy

Dialysable leukocyte extracts in immunotherapy

Immunotherapy with Dialyzable Leukocyte Extracts Containing Transfer Factor

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