Poster 014: Interferon Alpha Therapy for Aggressive Juvenile Ossifying Fibroma

Juvenile psammomatoid ossifying fibroma of the ethmoid sinus successfully treated by endoscopic sinus surgery: a case report

“…There are no effective medical therapies, because it is still unclear if the etiology is osteogenic (due to multipotential mesenchymal cells of the periodontal ligament), traumatic, or infective ( 20 ). Nonetheless, some author experienced a protocol for aggressive JOF, consisting in surgical removal in combination with adjuvant interferon-alpha therapy ( 20 , 21 ). In both open and endoscopic surgery, enucleation should be followed by the curettage or osteotomy of the apparently healthy bone tissue neat the margins of the tumour.…”

Juvenile Psammomatoid Ossifying Fibroma of the Forehead, Radical Resection, and Defect Coverage with a Hydroxyl-Apatite Composite—A Case Report

“…No recurrence after this treatment has been described. 17 A long-term follow-up after surgical excision is necessary; however, due to the high recurrence rate and described relapses several years after surgery, a standardized followup protocol after surgery does not exist. 14 In our reported case the histology postulated the diagnosis of FD.…”

Management of juvenile ossifying fibroma of the mandible in a patient with Apert syndrome: a case report

“…Surgery remains the primary modality of treatment in almost all cases of JOF 12 . Radiotherapy is of no value as the JOF is not believed to be radiosensitive and because of its adverse effects 12 ; adjuvant interferon therapy has been reported 20 …”

“…Surgery remains the primary modality of treatment in almost all cases of JOF 12 . Radiotherapy is of no value as the JOF is not believed to be radiosensitive and because of its adverse effects 12 ; adjuvant interferon therapy has been reported 20 Conservative management with enucleation and curettage has been advocated 11,15,21,22 , however, in contrast to other fibro-osseous lesions, JOF has a strong tendency to recur. Recurrence has been reported in 30-56% 5,9,17 of cases following surgical excision.…”