Postenucleation orbital radiotherapy for the treatment of malignant melanoma of the choroid with extrascleral extension.

The Prognostic Value of Extraocular Extension in Relation to Monosomy 3 and Gain of Chromosome 8q in Uveal Melanoma

“…In these three patients, one patient had metastasis at time of diagnosis (diameter extension of 40 mm) and another patient died due to a non-melanoma-related cause without metastasis (diameter extension of 9 mm) with a follow-up of 110.4 months at an age Orbital recurrence has been reported in 3% to 23% of the patients undergoing enucleation for UM with extraocular extension. 16,[21][22][23] In our study, only one patient, with an initial tumor-free surgical margin, had an orbital recurrence after 7 months and was exenterated. Nevertheless, orbital recurrence is described even 20 and 42 years after enucleation.…”

Uveal melanoma: management and outcome of patients with extraocular spread

“…In enucleated patients, recurrences are nonetheless observed in about 6% with postoperative irradiation of the orbit25 and 22% without 5 7. Within our study none of the enucleated patients developed a tumour recurrence.…”

Combined enucleation and orbitotomy for choroidal melanoma with orbital extension

“…Scarring of the mobile bulbar and forniceal conjunctiva encourages the formation of blind pockets in which lashes can become trapped. 3 We describe a case of cilia originating beneath the bulbar conjunctiva in a setting of previous intraocular surgery.…”

“…In general, small nodular extrascleral extensions noted incidentally on ultrasonography are managed by modifying enucleation so as to avoid transection of the area of involvement. 3 Beneficial role of adjuvant radiotherapy in such cases remains questionable. 3 Diffuse orbital involvement is best managed by exenteration, although long-term survival advantage offered by this procedure is not known.…”

“…3 Beneficial role of adjuvant radiotherapy in such cases remains questionable. 3 Diffuse orbital involvement is best managed by exenteration, although long-term survival advantage offered by this procedure is not known. [4][5][6][7][8] Larger but circumscribed orbital involvement may be excised via orbitotomy in conjunction with enucleation or proton beam radiotherapy.…”