Postembryonic neurogenesis in the central nervous system of the tobacco hornworm,Manduca sexta. III. Spatial and temporal patterns of proliferation

Booker, Ronald; Babashak, James; Kim, Jae Bum

doi:10.1002/(sici)1097-4695(199602)29:2<233::aid-neu8>3.0.co;2-b

Cited by 13 publications

(6 citation statements)

References 11 publications

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“…In grasshopper embryos, it appears that the selective pattern of cell death plays a prominent role in establishing the segmental differences in the neuronal types a lineage generates (Thompson and Siegler, 1993). A similar mechanism may also be involved during postembryonic neurogenesis in M. sexta (Booker et al, 1996). Thus, the large increases in BrdU-labeled cells in mushroom bodies of 20-hydroxyecdysone-treated D. punctata reported in the present study may be due to the prevention of cell death.…”

Section: Figuresupporting

confidence: 56%

“…We found that 20-hydroxyecdysone significantly increased the total number of BrdU-labeled cells during the long period of BrdU labeling, indicating that 20hydroxyecdysone not only enhances the mitotic rates of neurogenesis, but also increases the active life spans of mushroom bodies. In M. sexta, ecdysteroids appear to play a role in regulating the mitotic activity of anlage of adult optic lobes (Monsma and Booker, 1996). On the other hand, in the adult house cricket, A. domesticus, ecdysone appears to have an inhibitory effect on neurogenesis of mushroom bodies (Cayre et al, 1997).…”

Section: Figurementioning

confidence: 99%

“…The involvement of ecdysteroids in insect nervous system reorganization, such as programmed cell death, maturation of arrested cells, and neuronal remodeling, has been well documented . In M. sexta, it has recently been demonstrated that the neurogenesis in the outer optic ganglia appears to be regulated by 20-hydroxyecdysone (Monsma and Booker, 1996). Previously, the mitogenic effects of ecdysteroids on Tenebrio accessory glands (Szopa et al, 1985), and Manduca epidermis (Kato and Riddiford, 1987), as well as on Diploptera punctata and Bombyx mori corpora allata (CA, Chiang et al, 1995Chiang et al, , 1997, have been reported.…”

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confidence: 99%

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Mitogenic effects of 20-hydroxyecdysone on neurogenesis in adult mushroom bodies of the cockroach,Diploptera punctata

Tsia

Chiang³

et al. 1999

J. Neurobiol.

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The purpose of this study was to examine the mitogenic effects of 20‐hydroxyecdysone on neurogenesis in mushroom bodies of the adult cockroach, Diploptera punctata. The occurrence of neurogenesis was studied immunocytochemically after in vivo labeling with 5‐bromo‐2′‐deoxyuridine (BrdU). The number of BrdU‐labeled cells in the mushroom bodies was high shortly after adult ecdysis, then gradually decreased, and proliferation ceased on day 8. 20‐Hydroxyecdysone injection during the early adult stages significantly delayed the decrease in mitotic activity. Moreover, 20‐hydroxyecdysone injection during the late stage stimulated quiescent mushroom body neuroblasts to initiate their mitotic activity in a dose‐dependent manner. These results indicated that the mushroom body neuroblasts of this insect become quiescent in the maturing central nervous system, but retain the capacity for proliferation if exposed to appropriate environmental signals. We conclude that 20‐hydroxyecdysone has a mitogenic effect on neurogenesis in mushroom bodies of this insect. © 1999 John Wiley & Sons, Inc. J Neurobiol 39: 264–274, 1999

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Section: Figuresupporting

confidence: 56%

Section: Figurementioning

confidence: 99%

mentioning

confidence: 99%

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Mitogenic effects of 20-hydroxyecdysone on neurogenesis in adult mushroom bodies of the cockroach,Diploptera punctata

Tsia

Chiang³

et al. 1999

J. Neurobiol.

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“…During metamorphosis many adult-specific neurons in the ventral ganglia are targeted by programmed cell death, particularly in abdominal segments (Bello et al, 2003;Booker and Truman, 1987;Booker et al, 1996). Furthermore, extensive cell death occurs during postembryonic development in the insect visual system, where cells are overproduced and those that do not make the appropriate targets are eliminated by apoptosis (Bonini and Fortini, 1999).…”

Section: Discussionmentioning

confidence: 99%

Lineage-specific cell death in postembryonic brain development ofDrosophila

2009

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The Drosophila central brain is composed of thousands of neurons that derive from approximately 100 neuroblasts per hemisphere. Functional circuits in the brain require precise neuronal wiring and tight control of neuronal numbers. How this accurate control of neuronal numbers is achieved during neural development is largely unclear. Specifically, the role of programmed cell death in control of cell numbers has not been studied in the central brain neuroblast lineages. Here, we focus on four postembryonic neuroblast lineages in the central brain identified on the basis that they express the homeobox gene engrailed (en). For each lineage,we determine the total number of adult-specific neurons generated as well as number and pattern of en-expressing cells. We then demonstrate that programmed cell death has a pronounced effect on the number of cells in the four lineages; approximately half of the immature adult-specific neurons in three of the four lineages are eliminated by cell death during postembryonic development. Moreover, we show that programmed cell death selectively affects en-positive versus en-negative cells in a lineage-specific manner and, thus, controls the relative number of en-expressing neurons in each lineage. Furthermore, we provide evidence that Notch signaling is involved in the regulation of en expression. Based on our findings, we conclude that lineage-specific programmed cell death plays a prominent role in the generation of neuronal number and lineage diversity in the Drosophila brain.

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“…Doe and Technau 1993;Goodman and Doe 1993;Doe and Skeath 1996;Urban and Technau 1997;Campos-Ortega and Hartenstein 1997;Doe et al 1998;Skeath 1999;Matsuzaki 2000;Skeath and Thor 2003;Technau et al 2006). While most studies on insect neurogenesis have been carried out in grasshoppers and the fruit fly, studies on other insects such as the moth Manduca sexta (Booker and Truman 1987;Booker et al 1996) and the beetle Tenebrio molitor (Breidbach and Urbach 1996; indicate the universal presence of neuroblasts in this taxon (review . Neuroblasts were also studied in the silverfish, a primarily wingless insect and the array of neuroblasts in this species is evolutionarily conserved in the winged insects (Truman and Ball 1998).…”

Section: Introductionmentioning

confidence: 99%

Engrailed-like immunoreactivity in the embryonic ventral nerve cord of the Marbled Crayfish (Marmorkrebs)

2008

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The homeobox transcription factor Engrailed is involved in controlling segmentation during arthropod germ band formation but also in establishing individual neuronal identities during later embryogenesis. In Crustacea, most studies analysing the expression of Engrailed so far have focussed on its function as segment polarity gene. In continuation to these previous studies, we analysed the neuronal expression of the Engrailed protein by immunohistochemistry in the embryonic nerve cord of a parthenogenetic crustacean, the Marbled Crayfish (Marmorkrebs). We paid particular attention to the individual identification of Engrailed expressing putative neuroblasts in the crayfish embryos. Engrailed positive cells in the neuroectoderm were counted, measured and mapped from 38 to 65% of embryonic development. That way, several Engrailed positive putative neuroblasts and putative neurons were identified. Our findings are compared with earlier studies on Engrailed expression during germ band formation in Crustacea. Recent data on neurogenesis in an amphipod crustacean have provided compelling evidence for the homology of several identified neuroblasts between this amphipod and insects. The present report may serve as a basis to explore the question if during crustacean neurogenesis additional communalities with insects exist.

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Postembryonic neurogenesis in the central nervous system of the tobacco hornworm,Manduca sexta. III. Spatial and temporal patterns of proliferation

Cited by 13 publications

References 11 publications

Mitogenic effects of 20-hydroxyecdysone on neurogenesis in adult mushroom bodies of the cockroach,Diploptera punctata

Mitogenic effects of 20-hydroxyecdysone on neurogenesis in adult mushroom bodies of the cockroach,Diploptera punctata

Lineage-specific cell death in postembryonic brain development ofDrosophila

Engrailed-like immunoreactivity in the embryonic ventral nerve cord of the Marbled Crayfish (Marmorkrebs)

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