2014
DOI: 10.1007/s10552-014-0435-x
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Postdiagnosis body mass index and risk of mortality in colorectal cancer survivors: a prospective study and meta-analysis

Abstract: While the present study as well as single previously published studies showed that overweight was associated with a non-significant reduced risk for all-cause mortality, our meta-analysis indicated a decreased mortality risk among overweight CRC survivors.

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Cited by 134 publications
(116 citation statements)
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“…These findings demonstrated an important principle: an established link between an exposure (here, adiposity) and increased cancer incidence does not necessarily extrapolate into an inferior post-treatment outcome. The paper from Sabrina Schlesinger et al [5], in this issue of the journal, adds a new dimension to this debate focusing on relationships of post-diagnosis BMI (as an indicator of the steady-state weight among survivors) and survival. They conducted a prospective cohort study on 2,143 CRC survivors in Germany, and combining their results with four additional studies, they provide evidence of a decreased mortality risk among overweight (postdiagnosis BMI 25.0-29.9 kg/m 2 ) compared with normal weight (post-diagnosis BMI 18.5-24.9 kg/m 2 ) CRC survivors.…”
mentioning
confidence: 99%
“…These findings demonstrated an important principle: an established link between an exposure (here, adiposity) and increased cancer incidence does not necessarily extrapolate into an inferior post-treatment outcome. The paper from Sabrina Schlesinger et al [5], in this issue of the journal, adds a new dimension to this debate focusing on relationships of post-diagnosis BMI (as an indicator of the steady-state weight among survivors) and survival. They conducted a prospective cohort study on 2,143 CRC survivors in Germany, and combining their results with four additional studies, they provide evidence of a decreased mortality risk among overweight (postdiagnosis BMI 25.0-29.9 kg/m 2 ) compared with normal weight (post-diagnosis BMI 18.5-24.9 kg/m 2 ) CRC survivors.…”
mentioning
confidence: 99%
“…Obesity is a factor associated with the risk of occurrence of multiple malignancies (1, 2, 13-15) and the risk of developing metastases in the course of some malignancies (3,16). However, a favorable influence of overweight and obesity on the course of some neoplastic diseases have been also observed (17)(18)(19). Recently, a few studies have reported a relation between obesity and overweight and better prognosis in some cancer patients (20)(21)(22).…”
Section: Discussionmentioning
confidence: 99%
“…For that reason, investigators have hypothesized that overweight/obesity leads to worse colorectal cancer (CRC) prognosis. However, though previous studies have shown an apparently elevated mortality risk in class II/III obese (BMI≥35 kg/m 2 ) patients 10-12 , associations of class I obesity (BMI 30-<35 kg/m 2 ) and survival are mixed; some studies show a higher mortality risk 6, 10, 13-16 and others show no higher 17 or a possible lower 18 mortality risk, depending in part on when BMI is measured relative to diagnosis. Overweight and obese CRC patients have shown lower mortality risks 11, 18 compared with normal- or underweight patients when BMI is measured following diagnosis but concerns are that this “obesity paradox” could reflect sampling selection bias, reverse causality, and/or collider bias 19-21 .…”
Section: Introductionmentioning
confidence: 95%