Postdevelopmental Effects of Boron, Fluoride, and Their Combination on Dental Caries Activity in the Rat

Liu, F.T.Y.

doi:10.1177/00220345750540014401

Cited by 16 publications

(5 citation statements)

References 7 publications

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“…Losee and Ludwig [41], Curzon et al [42], and Curzon [43] suggested a cariostatic role for B based on less incidence of caries in areas with abundant B in drinking water and food. However, Liu [44] found that B did not reduce enamel caries activity in an experimental rat model. The lack of an effect may be related to Liu determining the effect of B supplementation on postdevelopmental molar caries activity in B-adequate rats.…”

Section: Discussionmentioning

confidence: 96%

“…The lack of an effect may be related to Liu determining the effect of B supplementation on postdevelopmental molar caries activity in B-adequate rats. Liu [44] also found that B administered in combination with fluoride (F) in the drinking water had a partially antagonistic effect on the cariostatic action of F. The antagonism may be the result of the formation of the anionic complex BF 4 , which was suggested to be the mechanism through which B counters F toxicity [45].…”

Section: Discussionmentioning

confidence: 99%

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Histomorphometric and Microchemical Characterization of Maturing Dental Enamel in Rats Fed a Boron-Deficient Diet

Durand¹,

Mesones²,

Nielsen³

et al. 2009

Biol Trace Elem Res

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Few reports are available in the literature on enamel formation under nutritional deficiencies. Thus, we performed a study to determine the effects of boron (B) deficiency on the maturing dental enamel, employing the rat continuously erupting incisor as the experimental model. Male Wistar rats, 21 days old, were used throughout. They were divided into two groups, each containing ten animals: +B (adequate; 3-mg B/kg diet) and -B (boron deficient; 0.07-mg B/kg diet). The animals were maintained on their respective diets for 14 days and then euthanized. The mandibles were resected, fixed, and processed for embedding in paraffin and/or methyl methacrylate. Oriented histological sections of the continuously erupting incisor were obtained at the level of the mesial root of the first molar, allowing access to the maturation zone of the developing enamel. Dietary treatment did not affect food intake and body weight. Histomorphometric evaluation using undecalcified sections showed a reduction in enamel thickness (hypoplasia), whereas microchemical characterization by energy-dispersive X-ray spectrometry did not reveal alterations in enamel mineralization.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Histomorphometric and Microchemical Characterization of Maturing Dental Enamel in Rats Fed a Boron-Deficient Diet

Durand¹,

Mesones²,

Nielsen³

et al. 2009

Biol Trace Elem Res

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show abstract

“…The use of fluoride as an anticaries agent is now generally accepted. [1][2][3] Its influence has been attributed to either the reduction of the growth rate of micro-organisms responsible for acid generation which leads to caries formation,45 or the incorporation of fluoride in the surface layers of the enamel, either from topical fluoride treatment or from drinking water, forming a fluorapatite phase [Ca5(PO4)3F,(FAP)] . [6][7] Since FAP is less soluble than hydroxyapatite [Ca5(PO4)30H, (HAP)], the surface is regarded as being more resistant to acid attack.…”

Section: Usamentioning

confidence: 99%

The Growth of Calcium Phosphates on Hydroxyapatite Crystals. The Effect of Fluoride and Phosphonate

Barone

Nancollas

1978

J Dent Res

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The nature of the calcium phosphate phase which precipitates on hydroxyapatite seed crystals can be controlled by varying the HAP seed concentration. At low seed concentrations, dicalcium phosphate dihydrate (DCPD) is formed while at high seed levels a more basic phase precipitates. It has been found that fluoride ion increases the percentage of basic phase that crystallizes while ethylidenediphosphonic acid encourages the formation of DCPD. This behavior is explained by the competition between the nucleation of DCPD and the crystal growth on sites already present on the HAP seeds.

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“…The significant negative correlation was present only in non-carious teeth group. In Lius' study (29), when boron and fluoride are added together to drinking water in rats fed a cariogenic diet, boron has been shown to reduce the caries protection effect of fluoride. It has been suggested that boron may inhibit the fluoride absorption from the gastrointestinal system.…”

Section: Discussionmentioning

confidence: 99%

“…However, in the literature, it is unclear whether the boron has a cariogenic, anticariogenic or cariostatic effect on the teeth. Moreover, studies on the tooth boron level are very limited (3,16).…”

Section: Introductionmentioning

confidence: 99%

The Level of Two Trace Elements in Carious, Non-Carious, Primary, and Permanent Teeth

et al. 2020

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Purpose: The boron and fluoride mainly accumulate in the bones and teeth of the human body. The purpose of this study is to determine boron or fluoride levels in the whole tooth, to evaluate the correlation between their levels and to compare these levels in primary/permanent, carious, and non-carious groups. Materials and methods: The boron and fluoride levels of thirty-six teeth, separated such as primary carious (n=9) and non-carious (n=9), permanent carious (n=9) and non-carious (n=9), were determined by ICP-MS and ion-selective electrode, respectively. Results: While boron levels were between 0.001 and 5.88 ppm, the fluoride levels were between 21.24 and 449.22 ppm. The boron level of non-carious teeth was higher than those of carious teeth in primary and permanent tooth groups. However, this difference was not statistically significant (p>0.05). The fluoride level of non-carious teeth was higher than those of carious teeth in primary (p=0.062) and permanent teeth groups (p=0.046). Negative correlation, found between boron and fluoride in all groups, was significant only in non-carious teeth group (r=-0.488, p=0.040). Conclusion: The results of our study proved the importance of fluoride as a protective factor for dental caries once more. The boron levels in non-carious teeth were also higher than carious teeth. However, it was not significant. Moreover, there was negative correlation between teeth boron and fluoride levels. Therefore, it is necessary to conduct more detailed studies on the tooth boron level and its relation with caries formation and with fluoride levels.

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Postdevelopmental Effects of Boron, Fluoride, and Their Combination on Dental Caries Activity in the Rat

Cited by 16 publications

References 7 publications

Histomorphometric and Microchemical Characterization of Maturing Dental Enamel in Rats Fed a Boron-Deficient Diet

Histomorphometric and Microchemical Characterization of Maturing Dental Enamel in Rats Fed a Boron-Deficient Diet

The Growth of Calcium Phosphates on Hydroxyapatite Crystals. The Effect of Fluoride and Phosphonate

The Level of Two Trace Elements in Carious, Non-Carious, Primary, and Permanent Teeth

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