Postcontest blockade of dopamine receptors inhibits development of the winner effect in the California mouse (Peromyscus californicus).

Becker, Elizabeth A.; Marler, Catherine A.

doi:10.1037/bne0000043

Cited by 26 publications

(20 citation statements)

References 78 publications

(141 reference statements)

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“…Additionally, the dopamine agonist methamphetamine increases aggressive behavior in rodents (Miczek, 1974;Miczek and Haney, 1994;Yu et al, 2014), whereas systemic injections of Drd1or Drd2-family antagonists decrease reactive aggression in residentintruder procedures (Kudryavtseva et al, 1999;Fragoso et al, 2016). In California mice, systemic injections of Drd1-and Drd2-family antagonists delay the emergence of a resident-intruder winner during repeated antagonistic encounters (Becker and Marler, 2015). These data indicate a role for both Drd1 and Drd2 in reactive aggression.…”

Section: Appetitive Aggression Reward In Rodentsmentioning

confidence: 84%

Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice

et al. 2019

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We recently developed a mouse model of appetitive operant aggression and reported that adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male mice and relapse to aggression seeking during abstinence. Here we studied the role of nucleus accumbens (NAc) dopamine receptor (Drd)1-and Drd2-expressing neurons in aggression self-administration and aggression seeking. We trained CD-1 mice to self-administer intruders (9 d, 12 trials/d) and tested them for aggression self-administration and aggression seeking on abstinence Day 1. We used immunohistochemistry and in situ hybridization to measure the neuronal activity marker Fos in the NAc, and cell-type-specific colocalization of Fos with Drd1-and Drd2-expressing neurons. To test the causal role of Drd1-and Drd2-expressing neurons, we validated a transgenic hybrid breeding strategy crossing inbred Drd1-Cre and Drd2-Cre transgenic mice with outbred CD-1 mice and used cell-type-specific Cre-DREADD (hM4Di) to inhibit NAc Drd1-and Drd2-expressing neuron activity. We found that aggression self-administration and aggression seeking induced higher Fos expression in NAc shell than in core, that Fos colocalized with Drd1 and Drd2 in both subregions, and that chemogenetic inhibition of Drd1-, but not Drd2-, expressing neurons decreased aggression self-administration and aggression seeking. Results indicate a cell-type-specific role of Drd1-expressing neurons that is critical for both aggression self-administration and aggression seeking. Our study also validates a simple breeding strategy between outbred CD-1 mice and inbred C57-based Cre lines that can be used to study cell-type and circuit mechanisms of aggression reward and relapse.Aggression is often comorbid with neuropsychiatric diseases, including drug addiction. One form, appetitive aggression, exhibits symptomatology that mimics that of drug addiction and is hypothesized to be due to dysregulation of addiction-related reward circuits. However, our mechanistic understanding of the circuitry modulating appetitive operant aggression is limited. Here we used a novel mouse model of aggression self-administration and relapse, in combination with immunohistochemistry, in situ hybridization, and chemogenetic manipulations to examine how cell types in the nucleus accumbens are recruited for, and control, operant aggression self-administration and aggression seeking on abstinence Day 1. We found that one population, dopamine receptor 1-expressing neurons, act as a critical modulator of operant aggression reward and aggression seeking.

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Section: Appetitive Aggression Reward In Rodentsmentioning

confidence: 84%

Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice

et al. 2019

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“…A related study showed that D2R, but not D1R, antagonist infusion into the NAc of abnormally aggressive low-anxiety bred rats decreases aggression (Beiderbeck et al 2012). Interestingly, a more recent study found that both D1R and D2R antagonists injected systemically reduced both aggression and chances of winning a fight in experienced mice, but in this scenario the D1R antagonist had a stronger effect (Becker et al 2015). …”

Section: Regulation Of Aggression and Aggression Reward By Lhb Targetsmentioning

confidence: 99%

An emerging role for the lateral habenula in aggressive behavior

Flanigan

Aleyasin

Takahashi

et al. 2017

Pharmacology Biochemistry and Behavior

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Inter-male aggression is an essential component of social behavior in organisms from insects to humans. However, when expressed inappropriately, aggression poses significant threats to the mental and physical health of both the aggressor and the target. Inappropriate aggression is a common feature of numerous neuropsychiatric disorders in humans and has been hypothesized to result from the atypical activation of reward circuitry in response to social targets. The lateral habenula (LHb) has recently been identified as a major node of the classical reward circuitry and inhibits the release of dopamine from the midbrain to signal negative valence. Here, we discuss the evidence linking LHb function to aggression and its valence, arguing that strong LHb outputs to the ventral tegmental area (VTA) and the dorsal raphe nucleus (DRN) are likely to play roles in aggression and its rewarding components. Future studies should aim to elucidate how various inputs and outputs of the LHb shape motivation and reward in the context of aggression.

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“…Within this series of studies, it was further found that the T pulse itself is acting through androgen receptors to influence experience induced increases in ability to win, as aromatase inhibitors (which block conversion of T to estradiol) do not block the effects of T pulses (Trainor et al, 2004). In contrast, dopamine receptor antagonists administered after winning experiences (in mice exhibiting endogenous T pulses) effectively block winner effects (Becker and Marler, 2015). The involvement of dopamine signaling raises the possibility of reward-based mechanisms to be involved in the winner-challenge effect, as described below.…”

Section: Rapid and Long-term Effects Of T Pulses On Social Behavior mentioning

confidence: 99%

The challenge hypothesis revisited: Focus on reproductive experience and neural mechanisms

Marler

Trainor

2020

Hormones and Behavior

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Our review focuses on findings from mammals as part of a Special Issue "30th Anniversary of the Challenge Hypothesis". Here we put forth an integration of the mechanisms through which testosterone controls territorial behavior and consider how reproductive experience may alter these mechanisms. The emphasis is placed on the function of socially induced increases in testosterone (T) pulses, which occur in response to social interactions, as elegantly developed by Wingfield and colleagues. We focus on findings from the monogamous California mouse, as data from this species shows that reproductive status is a key factor influencing social interactions, site fidelity, and vigilance for offspring defense. Specifically, we examine differences in T pulses in sexually naïve versus sexually experienced pair bonded males. Testosterone pulses influence processes such as social decision making, the winner-challenge effect, and location preferences through rewarding effects of T. We also consider how social and predatory vigilance contribute to T pulses and how these interactions contribute to a territory centered around maximizing reproduction. Possible underlying mechanisms for these effects include the nucleus accumbens (rewarding effects of testosterone), hippocampus (spatial memories for territories), and the bed nucleus of the stria terminalis (social vigilance). The development of the challenge effect has provided an ideal framework for understanding the complex network of behavioral, environmental, physiological and neural mechanisms that ultimately relates to competition and territoriality across taxa. The opportunity to merge research on the challenge effect using both laboratory and field research to understand social behavior is unparalleled.

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Postcontest blockade of dopamine receptors inhibits development of the winner effect in the California mouse (Peromyscus californicus).

Cited by 26 publications

References 78 publications

Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice

Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice

An emerging role for the lateral habenula in aggressive behavior

The challenge hypothesis revisited: Focus on reproductive experience and neural mechanisms

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