Postconditioning Accelerates Myocardial Inflammatory Resolution Demonstrated by ¹⁴C-Methionine Imaging and Attenuates Ventricular Remodeling After Ischemia and Reperfusion

Levosimendan Postconditioning Attenuates Cardiomyocyte Apoptosis after Myocardial Infarction

“…Moreover, it exerted comparable antiapoptotic effects in organs such as the liver, lungs, and kidneys [ 20 – 24 ]. Even though recent studies have reported that pharmacological postconditioning is a potential method for preventing cardiac injury [ 25 , 26 ], studies on levosimendan postconditioning are few, compared to those on levosimendan preconditioning. Generally, levosimendan is used in cases of appropriate clinical indications, such as definitive MI [ 5 , 7 , 8 ].…”

Fantastic voyage: Catheter-based quantification of tracer distribution on a miniature scale

“…However, it is disappointing that this potential is not explored further, e.g., by confirmation of cellular substrate by histopathology. Indeed, while typical investigation requires alignment of adjacent tissue sections for ex vivo autoradiography, histology, and immunohistochemistry, 5,6 the b-detection catheter could better define the target regions of tracer enrichment to characterize the signal. A growing range of targeted inflammation radiotracers have displayed divergent uptake patterns in specific leukocyte subtypes in vitro with variable uptake in other cardiac cell subtypes including myocytes and fibroblasts.…”