Postcoital Prostaglandins, in Vivo Oviductal Motility, and Egg Transport in Rabbits

Aref, I; Hafez, E. S. E.; Kamar, G. A. R.

doi:10.1016/s0015-0282(16)39911-3

Cited by 23 publications

(12 citation statements)

References 6 publications

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“…In these ex periments animals were killed only 5 h after PG treatment. It was also reported that PGF,a treatment at 12 h after HCG was less effective in disrupting normal egg transport than was treatment at 24 h when animals were killed 36 h post coitum [1]. These temporal differences in the effec tiveness of PGF2a have been confirmed [11]; treatment before 12 h after HCG had no effect on the recovery of eggs from the oviducts, treatment at 12 or 16 h after HCG caused a 40 and 30% loss of eggs, respectively.…”

Section: Effect Of Prostaglandins On Egg Transportmentioning

confidence: 90%

“…Using a fluid-filled balloon placed in the rabbit ampulla adjacent to the ampullary-isthmic junction, the effects of PGE2 and PGF2a have been studied at several times after mating [1]. Oviductal motility was stimulated following the subcutaneous administration of 3, 6 or 12 mg PGF2a.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…PGEj and PGF2a accelerate tubal transport of eggs [1,9,10,17,18], but PGE2 has no effect [1,10]. Treatment with PGEX at 14 or 19 h after HCG was not effective, but treatment at 23 h after HCG did accelerate egg transport [17,18].…”

Section: Effect Of Prostaglandins On Egg Transportmentioning

confidence: 99%

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Effects of Prostaglandins on Oviductal Motility and Egg Transport

Spilman¹,

Harper²

1975

Gynecol Obstet Invest

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The effects of prostaglandins (PGs) on muscular activity of the oviductal isthmus and on the rate of tubal egg transport are reviewed. In consideration of the available data a mechanism by which PGs contribute to the physiological control of egg transport is suggested. Invivo experiments have demonstrated that E-series PGs relax while F-series PGs stimulate muscular activity of the oviduct in humans, subhuman primates and rabbits. These effects are mutually antagonistic. The response of oviductal muscle to PGs appears to be affected by ovarian steroids; progesterone increases the response to PGE₁ and decreases the response to PGF₂Α. Oviductal tissue concentrations of PGF increase in a distal to proximal sequence following ovulation-induction in the rabbit. Also, proximal isthmus binding of PGE₁ tended to be greater in 72-hour pregnant rabbits than in estrous rabbits, while binding of PGF₂Α was greater in estrous than in 72-hour pregnant animals. It is suggested that the preovulatory increase in ovarian estradiol secretion stimulates PGF synthesis in the oviductal tissue in a sequential fashion, the peak value occurring when the oviductal isthmus is most sensitive to stimulation by PGF₂Α. The changes in tissue concentration of PGF and in sensitivity to PGF₂Α could contribute to occlusion of the isthmus and prevent premature passage of eggs into the uterus. An increase in ovarian progesterone secretion after ovulation may decrease tissue PGF, decrease the response to PGF₂Α stimulation, and increase the response to PGE₁. These changes may then allow a progressive movement of eggs through the isthmus into the uterus. Several questions regarding this proposed mechanism remain unanswered.

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Section: Effect Of Prostaglandins On Egg Transportmentioning

confidence: 90%

Section: In Vivo Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Prostaglandins on Oviductal Motility and Egg Transport

Spilman¹,

Harper²

1975

Gynecol Obstet Invest

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“…In vivo studies in rabbits, some of which have included intraluminal pressure recording with balloon catheters, have shown that exogenous prostaglandin F 2(V (PGF 2(V ) stimulates tubal contractility and accelerates egg transport; PGE 2 , on the other hand, inhibits tubal contractility without modifying egg transport (69,106,107). Riehl and Harper (108) have since shown that in rabbits the number of PGE 2 receptors per cell increases in the isthmus after ovulation, whereas PGF 2( » receptors in the proximal isthmus decrease in number.…”

Section: Jansenmentioning

confidence: 99%

Endocrine Response in the Fallopian Tube

1984

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“…Regional and cyclic patterns of activity have been defined in detail with particular reference to changes with the reproductive cycle (Csapo & Pinto-Dantas, 1966;Hafez & Blandau, 1969; Aref, Hafez & Kamar, 1973). The ovarian musculature has also been investigated: spontaneous contractions have been demonstrated in several species and an involvement in the process of follicular rupture has been postulated (Rocereto, Jacobowitz & Wallach, 1969;Okamura, Virutamasen, Wright & Wallach, 1972;Diaz-Infante, Virutamasen, Connaughton, Wright & Wallach, 1974;Walles et al, 1975).…”

mentioning

confidence: 99%