Postchallenge hyperglycaemic spike associate with arterial stiffness

Abstract

Several large-scale epidemiological and intervention studies strongly indicate that postchallenge hyperglycaemia is the main factor associated with increasing the risk of morbidity and mortality in type 2 diabetes. However, the mechanisms that increase the risk of cardiovascular disease remain unclear. We aimed to study the relationship between postchallenge hyperglycaemia and arterial stiffness. We recruited 40 healthy subjects from a physical examination in 2005. Cardio-ankle vascular index (CAVI) was automatically calculated by VaSera VS-1000. For the reliability study, we performed the baseline study in the first 20 subjects who were returned to receive repeated measurements of CAVI 2 weeks later. The determinants of mean CAVI at different timings of oral glucose tolerance test (OGTT) study were analysed by constructing multivariate linear regression models. In reliability test, the inter-observer correlation coefficient was 0.82 for right CAVI, 0.87 for left CAVI and 0.85 for mean CAVI. Age, systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose levels at 60 min (Glu60) and glucose area under the curve of OGTT (GluAUC) are found to be significantly and positively correlated to right CAVI, left CAVI and mean CAVI (p < 0.05). After adjustment for age, gender and SBP, Glu60 and GluAUC are still independent determinants of CAVI. In subjects without clinical diagnosis of type 2 diabetes, postchallenge hyperglycaemic spike is highly associated with CAVI, a good parameter of aortic stiffness, independent of age, gender and blood pressure.

Short-term exercise training improves aerobic capacity with no change in arterial function in obesity

“…While group diVerences were not observed, the meal test did elicit an increase in central arterial stiVness. Previous studies reported that arterial stiVness is associated (»r = 0.33) with hyperglycemia during an OGTT (Huang et al 2007;Ohshita et al 2004). We also observed an association between glucose concentrations and central PWV (r = 0.37, P < 0.001), despite the use of diVerent techniques to assess arterial stiVness.…”

“…The exact mechanism for arterial dysfunction in persons with impaired glucose tolerance is currently debated (Cosentino et al 1997(Cosentino et al , 2003Edwards et al 2004). Elevated glucose concentrations following an oral glucose tolerance test (OGTT) are strongly associated with increased arterial stiVness in populations that have both normal and impaired glucose tolerance (Huang et al 2007;Ohshita et al 2004), suggesting that acute physiological (postprandial) hyperglycemia may have a detrimental eVect on arterial function. Endothelial function was observed to be decreased 1 and 2 h after administration of an OGTT to individuals with impaired glucose tolerance (Kawano et al 1999).…”

The Health Effects of a Forest Environment on Subclinical Cardiovascular Disease and Heath-Related Quality of Life

“…CAVI and ABI for each participant were conducted at least twice. The test-retest reliability of CAVI and ABI in the Taiwanese population has been demonstrated as excellent [24].…”

Availability of Cardio-Ankle Vascular Index (CAVI) as a Screening Tool for Atherosclerosis

“…8,12 CAVI is essentially independent of changes in BP during examination, but shows a strong correlation with systolic BP (SBP). 12 Although there are several reports of the evaluation of CAVI in patients on hemodialysis, 12 those with hyperglycemia 13 and those who had undergone heart transplantation, 14 there are few on the evaluation of CAVI as a screening tool for atherosclerosis in the general population, 11 and none about the correlation between CAVI and CIMT. Although we recently evaluated the availability of CAVI as a screening tool for atherosclerosis in young Japanese adult (mean age 21.4 years, range 18-31 years), no correlation was observed with other existing markers, including CIMT.…”