Postbronchodilator response of small airways after 800 microgrammes of salbutamol in COPD patients

Gemicioğlu, Bilun; Gundogdu, Şule; Öztürk, Buket Çalışkaner; Eren, Fatma

doi:10.1183/13993003.congress-2016.pa4139

Cited by 1 publication

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“…In this context, autonomic dysfunction was demonstrated in a study by de Carvalho et al ( 32 ), in which a reduction in the geometric indexes of HRV in individuals with COPD was found, indicating a reduction in the overall HRV ( 32 ). Bronchoconstriction in COPD patients is mainly driven by parasympathetic stimuli ( 33 ) and is commonly treated by β2-adrenergic receptor agonists, such as salbutamol/albuterol ( 34 ). However, previous studies have correlated reduced overall variability (a sign of increased sympathetic modulation) with airway inflammation present in COPD patients ( 31 , 35 ).…”

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confidence: 99%

Obesity as an additional factor for autonomic imbalance and poor sleep behavior in chronic obstructive pulmonary disease: a case-control study

Mostarda

Barboza

Cutrim

et al. 2021

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OBJECTIVES: We compared the autonomic modulation and sleep behavior of eutrophic and overweight patients with chronic obstructive pulmonary disease (COPD). METHODS: COPD participants were divided into the overweight and eutrophic groups. Pulmonary function, blood pressure, body composition, autonomic modulation, and the Pittsburgh Sleep Quality Index score were assessed. Participants performed the six-minute walk test for functional assessment. RESULTS: Spirometric variables obtained in eutrophic and overweight individuals with COPD showed no statistically different results. We observed that the SDNN index indicated lower overall variability ( p =0.003), and root mean square of successive differences between normal heart beats (RMSSD) ( p =0.04) indicated lower parasympathetic modulation in the overweight group than observed in the eutrophic group. The indexes of the frequency domain presented lower values of total variability ( p <0.01), low frequency bands ( p <0.01), and high frequency ( p =0.02), suggesting a higher sympathetic modulation and reduced parasympathetic modulation of the overweight group compared to eutrophic group. The overweight group also showed reduced sleep quality than the eutrophic group. CONCLUSION: Overweight COPD patients showed lower autonomic modulation and impaired sleep quality, latency, and efficiency as compared eutrophic subjects. These results reinforce the importance of weight control and the acquisition of healthy habits in this population.

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